Pathophysiology News and Research

RSS

Rhythmicity of activity linked to bipolar mania

Circadian rhythm disturbances are associated with bipolar disorder, and particularly with mania, indicate study findings.

12 Feb 2014

Rare and de novo mutations flesh out schizophrenia picture

Two studies in Nature show that rare disruptive and de novo mutations may contribute to the pathophysiology of schizophrenia.

6 Feb 2014

6-month-old infants later diagnosed with autism divert gaze from facial features

From birth, infants naturally show a preference for human contact and interaction, including faces and voices. These basic predispositions to social stimuli are altered in individuals diagnosed with autism spectrum disorders (ASD).

5 Feb 2014

Scientists, clinicians to examine role of human gut microbiota in digestive and overall health

The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting new areas of research today. To address the most recent advances in this rapidly developing field, scientists and health-care professionals from all over the world will come together at the Gut Microbiota for Health World Summit in Miami, Florida, on March 8 and 9, 2014.

24 Jan 2014

Cortical thickness may distinguish bipolar from unipolar disorder

Patients with depression have areas of reduced cortical thickness, with clear distinctions between those with bipolar disorder and major depressive disorder, report US researchers.

23 Jan 2014

BrainScope receives award from GE and NFL to enhance portable concussion assessment system

BrainScope Company, Inc. today announced that it has received an award from GE and the National Football League to further enhance its portable concussion assessment system by combining imaging biomarkers with its brainwave technology.

23 Jan 2014

Vitamin D deficiency may lead to stiffening of blood vessels

UV-B radiation in sunlight is the most important factor for the production of vitamin D, and that is why many people suffer from low levels of vitamin D during the winter months.

20 Jan 2014

Researchers discover fundamental biology of calcium waves in relation to heart arrhythmias

Researchers have discovered the fundamental biology of calcium waves in relation to heart arrhythmias. The findings published this month in the January 19 edition of Nature Medicine outlines the discovery of this fundamental physiological process that researchers hope will one day help design molecularly tailored medications that correct the pathophysiology.

20 Jan 2014

New way to improve lipid profiles in patients undergoing hemodialysis may prevent heart attack

Researchers at Wayne State University have discovered a potential way to improve the lipid profiles in patients undergoing hemodialysis that may prevent cardiovascular disease common in these patients.

16 Jan 2014

More evidence for glutamate dysregulation in schizophrenia

Levels of glutamine, but not glutamate, are elevated in the dorsal anterior cingulate of patients with established schizophrenia, say researchers.

15 Jan 2014

Presence of gene variant in people with MCI associated with accelerated rates of brain atrophy

The presence of a gene variant in people with mild cognitive impairment is associated with accelerated rates of brain atrophy, according to a new study published online in the journal Radiology.

15 Jan 2014

Trevena doses first patient in TRV027 Phase 2b trial for acute heart failure

Trevena, Inc., a clinical stage pharmaceutical company involved in the discovery and development of G-protein coupled receptor biased ligands, announced today initiation of dosing in BLAST-AHF, the Company's randomized, multi-center Phase 2b trial of TRV027 in patients with acute heart failure.

9 Jan 2014

Landes Bioscience releases special issue on sepsis

A special issue on sepsis has been released by the publisher Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Virulence have been authored by world-class investigators and provide new insights into both the pathogen-related factors and the host defense mechanisms that lead to septic shock and contribute to its resolution or fatal outcome.

7 Jan 2014

Portage acquires approximately 54% equity in Biohaven

Portage Biotech Inc., is pleased to announce that it has acquired approximately 54% equity in Biohaven Pharmaceutical Holding Company Limited, a private corporation formed under the laws of the British Virgin Islands, for $3.5 million, payable as $1.75 million upfront and the balance in three installments over the next eleven months.

6 Jan 2014

SUI and UUI show complex interrelationship

A study by US researchers has failed to identify any modifiable risk factors for urgency urinary incontinence among women undergoing surgery for stress urinary incontinence.

6 Jan 2014

Asthma link to mood disorders strengthened

Results from a prospective study support a relationship between asthma in adolescence and future diagnosis of mood disorders.

24 Dec 2013

Researchers identify potential therapy for meibomian gland dysfunction

Meibomian gland dysfunction is the leading cause of dry eye disease, which affects tens of millions of Americans. However, there is no FDA-approved treatment for MGD. Researchers from the Schepens Eye Research Institute/Massachusetts Eye and Ear and Harvard Medical School have just identified a potential therapy.

24 Dec 2013

Autoimmune clue to narcolepsy

Researchers have identified immune cells in patients with narcolepsy that react against hypocretin, the lack of which causes the disorder.

20 Dec 2013

Inflammatory burden increased in overweight bipolar disorder patients

Breakdown of the amino acid tryptophan is increased in euthymic, overweight individuals with bipolar disorder, show preliminary results from the BIPFAT study.

20 Dec 2013

NUS scientists open possible new route for treatment of spinal muscular atrophy

A recent study led by scientists from the National University of Singapore (NUS) opens a possible new route for treatment of Spinal Muscular Atrophy (SMA), a devastating disease that is the most common genetic cause of infant death and also affects young adults.

18 Dec 2013