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Studies suggest that stress-related disorders may be associated with hippocampal volume loss

Depression has been associated with reduced volume of the hippocampus in magnetic resonance imaging studies in humans. A new study just published in Biological Psychiatry now clarifies the cellular basis of these volumetric changes, which have been unclear until now.

18 Dec 2013

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

AstraZeneca and Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration's (FDA) Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) recommends the investigational medicine metreleptin for the treatment of pediatric and adult patients with generalized lipodystrophy (LD).

12 Dec 2013

Schizophrenia treatment responses follow distinct trajectories

The positive and negative symptoms of schizophrenia generally change in parallel with each other, shows research, supporting the notion that the different symptom domains of the condition have a shared underlying pathology.

11 Dec 2013

Genetic counseling could help bipolar patients adapt

Patients who believe their bipolar disorder is inherited tend to have a positive approach to coping with their condition, research suggests.

10 Dec 2013

Research findings suggest possible novel strategies to prevent SUDEP

Patients with epilepsy and, in particular, those with severe syndromic forms of the disorder, harbor a risk of sudden unexplained death in epilepsy, or SUDEP. Cardiac arrhythmias are a proposed cause. In a test of this theory, researchers have demonstrated that mice harboring a human SCN1A gene mutation that results in Dravet Syndrome, a severe and intractable genetic epilepsy, have electrical disturbances in the heart that culminate in ventricular fibrillation and sudden cardiac death.

9 Dec 2013

TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

Toll-like receptor 4 (TLR4) antibody, protein kinase B (AKT) inhibitor, LY 294002, and glycogen synthase kinase 3β (GSK-3β) inhibitor, LiCl, were used by Yu He and colleagues from Nantong University, China to attenuate or augment the effects of the TLR4-phosphatidylinositol 3 kinase (PI3K)/AKT-GSK-3β signaling pathway so as to identify the participation of this signaling system in the apoptosis of hippocampal neurons.

5 Dec 2013

Depression during pregnancy may affect child's mental health

Depression is a serious mental illness that has many negative consequences for sufferers. But depression among pregnant women may also have an impact on their developing babies.

4 Dec 2013

New study examines gender differences in prevalence and pathophysiology of COPD

A new study review authored by the University of Kentucky's Dr. David Mannino examines the gender differences in the prevalence, pathophysiology, and clinical presentation of chronic obstructive pulmonary disease (COPD) and how this information may ultimately be used to identify areas for future work.

4 Dec 2013

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

A new paper published in Biological Psychiatry suggests that cognitive behavioral therapy for posttraumatic stress disorder not only reduces symptoms but also affects the underlying biology of this disorder.

4 Dec 2013

3T MRI scanner allows Polish scientists to perform structural and functional imaging of human brain

The Nencki Institute of Experimental Biology in Warsaw launches research programs, which require state-of-the-art magnetic resonance scanner.

3 Dec 2013

Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Genetic research that will be published tomorrow in the New England Journal of Medicine suggests to Dr. André Lacroix, professor at the University of Montreal, that clinicians' understanding and treatment of a form of Cushing's syndrome affecting both adrenal glands will be fundamentally changed, and that moreover, it might be appropriate to begin screening for the genetic mutations that cause this form of the disease.

28 Nov 2013

Neuroimaging could predict psychosis treatment response

Assessing white matter integrity in patients with first-episode psychosis may predict who will respond to antipsychotic treatment, research suggests.

27 Nov 2013

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

The National Institutes of Health has awarded a research team at the Icahn School of Medicine at Mount Sinai $2.7 million to study systemic treatments for patients with moderate to severe atopic dermatitis (AD), also known as eczema.

26 Nov 2013

Enhancing the NMDA glutamate receptor causes antidepressant-like effects

Thirteen years ago, an article in this journal first reported that the anesthetic medication, ketamine, showed evidence of producing rapid antidepressant effects in depressed patients who had not responded to prior treatments. Ketamine works by blocking one of the targets for the neurotransmitter glutamate in the brain, the N-methyl-D-aspartate (NMDA) glutamate receptor.

20 Nov 2013

Elsevier launches two new open access journals in cardiology journals series

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the launch of two new open access journals in its cardiology journals series: International Journal of Cardiology-Heart & Vessels and International Journal of Cardiology-Metabolic & Endocrine.

20 Nov 2013

Special issue on Helicobacter pylori provides new insights into diagnosis, prevention and treatment

A special issue on Helicobacter pylori has been published by Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Gut Microbes have been authored by world-class investigators and provide new insights into the pathophysiology, diagnosis, prevention, and treatment of this microbe.

20 Nov 2013

mTOR protein: A key mediator of antidepressant effects of ketamine

Two years ago, mammalian target of rapamycin or mTOR, a signaling protein, was identified as a key mediator of the antidepressant effects of ketamine, the first rapidly acting antidepressant medication to be identified.

20 Nov 2013

Grave prognosis for heart patients with treatment-resistant hypertension

Patients with coronary artery disease have a particularly high risk for poor outcomes if they have treatment-resistant hypertension, shows an analysis of the Treating to New Targets trial.

18 Nov 2013

European Commission grants marketing authorization for Bayer HealthCare's Xofigo injection

Bayer HealthCare announced today that the European Commission has granted marketing authorization for Xofigo (radium Ra 223 dichloride) solution for injection for the treatment of adults with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastases. This decision follows a positive recommendation from the European Committee for Medicinal Products for Human Use in September of this year.

15 Nov 2013

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

The Brain & Behavior Research Foundation (formerly known as NARSAD, the National Alliance for Research on Schizophrenia and Depression), under the direction of Dr. Jeffrey Borenstein, President & CEO, has announced the latest recipients of its NARSAD Distinguished Investigator Grants.

8 Nov 2013

Pathophysiology News and Research

Studies suggest that stress-related disorders may be associated with hippocampal volume loss

FDA Advisory Committee recommends metreleptin for treatment of generalized lipodystrophy

Schizophrenia treatment responses follow distinct trajectories

Genetic counseling could help bipolar patients adapt

Research findings suggest possible novel strategies to prevent SUDEP

TLR4 antibody-mediated signaling system in apoptosis of hippocampal neurons

Depression during pregnancy may affect child's mental health

New study examines gender differences in prevalence and pathophysiology of COPD

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

3T MRI scanner allows Polish scientists to perform structural and functional imaging of human brain

Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Neuroimaging could predict psychosis treatment response

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

Enhancing the NMDA glutamate receptor causes antidepressant-like effects

Elsevier launches two new open access journals in cardiology journals series

Special issue on Helicobacter pylori provides new insights into diagnosis, prevention and treatment

mTOR protein: A key mediator of antidepressant effects of ketamine

Grave prognosis for heart patients with treatment-resistant hypertension

European Commission grants marketing authorization for Bayer HealthCare's Xofigo injection

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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