Pathophysiology News and Research

RSS

Use of menopausal hormone therapy associated with increased rate of dementia and Alzheimer's

Use of menopausal hormone therapy is associated with an increased rate of dementia and Alzheimer's disease, suggests a large Danish study published by The BMJ today.

28 Jun 2023

BU researcher receives $2.8M grant to study serotonin's role in chronic stress and depression

Michael Wallace, PhD, assistant professor of anatomy & neurobiology at Boston University Chobanian & Avedisian School of Medicine, was awarded a $2.8 million from the National Institutes of Health, National Institute of Mental Health.

23 Jun 2023

Vagus nerve dysfunction has a central pathogenic role in the pathophysiology of the post-COVID condition

Researchers studied if vagus nerve dysfunction has a central pathogenic role in the pathophysiology of the post-COVID condition.

21 Jun 2023

Building resilient brains: strategies for promoting brain health in older adults

Researchers reviewed the overarching theme of brain health from the perspective of aging and preventive care.

21 Jun 2023

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Researchers evaluated the function of the zinc finger transcription factor ROB1 and its two phenotypically distinct alleles in the pathogenesis of Candida albicans infections.

20 Jun 2023

Investigating the relationship between red blood cells and the clinical course of COVID-19 in children

Study investigates the characteristics of RBCs after SARS-CoV-2.

20 Jun 2023

Could mutated blood cells hold the key to lower Alzheimer's risk?

Researchers tested whether clonal hematopoiesis of indeterminate potential (CHIP) status was associated with Alzheimer's disease.

19 Jun 2023

Gut microbiota holds clues to predicting Alzheimer's risk

Gut microbiome alterations in preclinical Alzheimer's disease (AD) were investigated, revealing distinct taxonomic composition and potential markers of AD risk. These findings contribute to understanding AD pathology and offer insights into gut-derived markers for AD.

15 Jun 2023

Review: Pathophysiology, diagnosis and management of carcinoid heart disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal.

15 Jun 2023

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Obesity-induced neuroinflammation significantly contributes to the pathophysiology of depression and Alzheimer's disease. Targeting midlife stage for intervention is crucial to potentially prevent Alzheimer's pathology.

13 Jun 2023

Spinal neural circuit dysfunction mediates movement symptoms in dystonia

Many neurological conditions that involve involuntary muscle contractions have long been considered as diseases of the brain.

6 Jun 2023

Research sheds new light on the genetic architecture of bipolar disorder

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity.

5 Jun 2023

Can adherence to the Mediterranean diet reduce gestational stress and anxiety in pregnant women?

Researchers investigated the influence of structured Mediterranean diet intervention on the anxiety and stress levels.

1 Jun 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

To commemorate World Multiple Sclerosis (MS) Day, we speak to Dr. Cameron McAlpine about his latest research that sought to understand better the proteins and signals that act as messengers between brain and immune cells in MS.

30 May 2023

Unlocking the brain-lung dialogue key to future treatments for critical care patients

Researchers review evidence on the crosstalk between the lung and brain and identified potential areas for further research.

29 May 2023

Insights into the direction and extent of gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment

Researchers performed a meta-analysis to determine the association between intestinal microbiota and Alzheimer’s disease (AD).

26 May 2023

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.