Peripheral Artery Disease News and Research

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Peripheral arterial disease (PAD) occurs when leg arteries become narrowed or blocked by plaque. These blockages can result in severe pain for patients, limited physical mobility, and life-threatening non-healing leg ulcers. According to the American Heart Association, this condition affects approximately 8 to 12 million Americans. With only about 25 percent of PAD patients undergoing treatment, it is a disease that is largely under-diagnosed and under-treated. If left untreated, PAD can lead to critical leg ischemia, a condition where not enough blood is being delivered to the leg to keep the tissue alive. Total loss of circulation to the legs and feet can cause gangrene and lead to amputation.

Cell-selective nanotherapy can help treat atherosclerotic plaques

Percutaneous coronary intervention (PCI), commonly known as angioplasty with a stent, opens clogged arteries and saves lives. Despite its benefit in treating atherosclerosis that causes coronary artery disease, this common minimally-invasive procedure still poses severe complications for some patients.

11 Feb 2021

Mid-term clinical trial results of two cell therapies for critical limb ischemia show similar outcomes

Mid-term results of the first clinical trial designed specifically to evaluate the safety and effectiveness of two cell therapies that are showing early promise in treating angiitis-induced critical limb ischemia were released today in STEM CELLS Translational Medicine.

5 Jan 2021

First human clinical trial validates the practicality, accuracy of oxygen-sensing liquid bandage

In the first human clinical trial, researchers at Massachusetts General Hospital and surgeons at Beth Israel Deaconess Medical Center have validated the practicality and accuracy of an oxygen-sensing liquid bandage that measures the concentration of oxygen in transplanted tissue

22 Dec 2020

Study: Paclitaxel-coated devices do not increase mortality for patients with peripheral artery disease

An interim analysis from the Swedish Drug-Elution Trial in Peripheral Arterial Disease (SWEDEPAD) has now been presented.

10 Dec 2020

Mayo Clinic study identifies trends in statin use across the U.S.

People who have coronary artery disease, stroke or peripheral artery disease often are prescribed a statin, a cholesterol-lowering drug that reduces the risk of heart attack or stroke.

1 Dec 2020

People with heart disease can receive high-dose or standard-dose flu vaccines for protection

People with heart disease can receive either the high-dose or standard-dose flu vaccines for protection from heart or lung-related deaths or hospitalizations, according to late breaking research presented today at the American Heart Association's Scientific Sessions 2020.

18 Nov 2020

Study: Many COVID-19 patients suffer cardiovascular damage even after recovery

One of the most harrowing effects of COVID-19 is severe damage to the lungs, which makes breathing hard or impossible for those who're severely affected.

21 Aug 2020

Study finds increase in comorbidities, mortality risk among hospitalized patients with heart failure

A study recently published in the journal Circulation looks at temporal trends in the burden of comorbidities and associated risk of mortality among patients with heart failure (HF) with preserved ejection fraction (HFpEF), in which the left ventricle of the heart is not able to relax enough to fill properly with blood, and HF with reduced ejection fraction (HFrEF), in which the left ventricle is not able contract enough to pump out as much blood.

30 Jul 2020

Heart failure poses the greatest risk of death for people with type 2 diabetes

Heart failure posed the greatest 5-year risk of death for people newly diagnosed with Type 2 diabetes than any other heart or kidney disease, according to new research published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

23 Jun 2020

COVID-19 and blood group in aortic valve replacement

The COVID-19 pandemic has been found to cause disproportionate harm in patients with cardiovascular disease, especially among the elderly population, among other risk factors. However, a new study published on the preprint server medRxiv* in June 2020 is the first to report its clinical features in patients with aortic stenosis who have had a transcatheter aortic valve replacement (TAVR).

18 Jun 2020

Anticardiolipin antibodies and COVID-19

A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19.

10 Jun 2020

Dual-pathway approach can lead to better outcomes in patients with heart stents

Pairing a blood-thinning drug with aspirin daily for patients who have an angioplasty with a stent can contribute to better health outcomes, including lower risk of death, than aspirin alone, according to a recent study by cardiologists at the University of Alberta and Mazankowski Alberta Heart Institute.

28 May 2020

Study provides indications and techniques of lower extremity revascularization

Lower extremity artery disease is a leading cause of morbidity and mortality worldwide, affecting hundreds of millions of people.

7 May 2020

Nanostimulators can amp up stem cells' regenerative powers for muscle repair

In regenerative medicine, an ideal treatment for patients whose muscles are damaged from lack of oxygen would be to invigorate them with an injection of their own stem cells.

3 May 2020

Clopidogrel added to aspirin and rvaroxaban shows no additional benefit for peripheral artery disease

The results of VOYAGER PAD found that people with peripheral artery disease (PAD) who took the blood thinner rivaroxaban with aspirin after undergoing lower extremity revascularization--a procedure to treat blocked arteries in the leg--had a significant reduction in the risk of major adverse limb and cardiovascular events when compared with those receiving aspirin alone.

31 Mar 2020

Low-dose rivaroxaban reduces adverse heart events in symptomatic PAD post-intervention

People with symptomatic peripheral artery disease who took the blood thinner rivaroxaban with aspirin after undergoing a procedure to treat blocked arteries in the leg (lower extremity revascularization) had a 15% reduction in the risk of major adverse limb and cardiovascular events when compared with those receiving aspirin alone, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Peripheral Artery Disease News and Research

Cell-selective nanotherapy can help treat atherosclerotic plaques

Mid-term clinical trial results of two cell therapies for critical limb ischemia show similar outcomes

First human clinical trial validates the practicality, accuracy of oxygen-sensing liquid bandage

Study: Paclitaxel-coated devices do not increase mortality for patients with peripheral artery disease

Mayo Clinic study identifies trends in statin use across the U.S.

People with heart disease can receive high-dose or standard-dose flu vaccines for protection

Study: Many COVID-19 patients suffer cardiovascular damage even after recovery

Study finds increase in comorbidities, mortality risk among hospitalized patients with heart failure

Heart failure poses the greatest risk of death for people with type 2 diabetes

COVID-19 and blood group in aortic valve replacement

Anticardiolipin antibodies and COVID-19

Dual-pathway approach can lead to better outcomes in patients with heart stents

Study provides indications and techniques of lower extremity revascularization

Nanostimulators can amp up stem cells' regenerative powers for muscle repair

Clopidogrel added to aspirin and rvaroxaban shows no additional benefit for peripheral artery disease

Low-dose rivaroxaban reduces adverse heart events in symptomatic PAD post-intervention

More protein intake could cut the risk of developing atrial fibrillation in women

Researchers prove the ability to grow human-derived blood vessels in a pig

Healthy lifestyle for longer keeps disease at bay

Researchers identify major landmarks of peripheral artery disease recovery

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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