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Experts identify a novel fucosylated heparan sulfate from the midgut gland of the Japanese scallop

Glycosaminoglycans (GAGs), including chondroitin sulfate (CS), heparan sulfate (HS), heparin, and hyaluronan are linear and acidic polysaccharides found in the extracellular matrix of all animal tissues. GAGs are widely used as functional ingredients in health products, pharmaceuticals, and cosmetics, and are prepared from biological samples such as shark cartilage and porcine intestinal mucosa. Consequently, the demand for new sources of GAGs is ever-present. For example, the supply source of the anticoagulant heparin-;generally prepared from porcine intestinal mucosa in China-;was threatened by African swine fever in 2018.

15 Jun 2023

Study offers a new perspective on the reproductive toxicity of phthalates

Prenatal exposure to chemicals called phthalates, which are used in hundreds of products, may lead to hormonal changes in females that could affect their future fertility, suggests a study in mice being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

'Concerning' CT findings may be an important barrier to discharge of low-risk pulmonary embolism patients

Of approximately 250,000 Americans diagnosed with acute pulmonary embolism, or PE, in emergency departments each year, most are hospitalized.

15 Jun 2023

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Crossing the membrane is a major challenge on the journey through the cell. Large biomolecules usually benefit from different transport strategies to overcome the lipid bilayer, so the design and synthesis of new carriers is key for the delivery of hydrophilic substances, such as pharmaceuticals, into the cell.

14 Jun 2023

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

13 Jun 2023

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Researchers explored the antioxidant and anti-inflammatory properties of bamboo leaves and sheaths.

13 Jun 2023

Debt deal leaves health programs (mostly) intact

A final deal cut between President Joe Biden and House Republicans extends the U.S. debt ceiling deadline to 2025 and reins in some spending.

8 Jun 2023

Experimental drug may slow the progression of atherosclerosis

An experimental drug already tested as a potential treatment for cancer, lung disease, and Alzheimer's disease may slow the progression of atherosclerosis that leads to heart disease, a new study shows.

8 Jun 2023

Promising targeted therapy offers new hope to certain patients with advanced pancreatic cancer

A promising new targeted cancer therapy will soon be available to certain patients with advanced pancreatic cancer – from the comfort of their home.

7 Jun 2023

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

In an international study co-led by UCLA, scientists have shown that a new targeted therapy drug can extend the amount of time people with a subtype of glioma are on treatment without their cancer worsening.

4 Jun 2023

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity of key cells and signaling pathways, a new study shows.

2 Jun 2023

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Lupus Therapeutics announced the start of a collaboration to conduct three Phase 3 clinical trials testing an investigational therapeutic ianalumab for systemic lupus erythematosus and lupus nephritis.

2 Jun 2023

Many people living in the ‘diabetes belt’ are plagued with medical debt

Delores Lowery remembers vividly the day in 2016 when she was working in a weaving plant near her home in Bennettsville, South Carolina, and the world around her seemed to go dim.

30 May 2023

High prevalence of galactagogue use among breastfeeding mothers in U.S.

Researchers describe the prevalence of galactagogue use among breastfeeding mothers in the United States and their perceived effects on milk production.

29 May 2023

Physical activity in the afternoon provides greatest improvements in glucose control for patients with type 2 diabetes

Over 37 million Americans have diabetes, and 90-95% of that population are diagnosed with type 2 diabetes.

25 May 2023

This panel will decide whose medicine to make affordable. Its choice will be tricky.

Catherine Reitzel's multiple sclerosis medication costs nearly $100,000 a year. Kris Garcia relies on a drug for a blood-clotting disorder that runs $10,000 for a three-day supply. And Mariana Marquez-Farmer would likely die within days without her monthly $300 vial of insulin.

25 May 2023

Bridging the Gap between Academia and Industry: The Power of Collaboration in Life Sciences

In this behind-the-scenes interview, we speak to Dr. Sinead Knight, chair of SLAS Europe 2023, about this years programme, highlighting the key topics and speakers.

From Society for Laboratory Automation and Screening (SLAS) 25 May 2023

Study maps cellular responses to blood sugar

Researchers at The University of Texas at El Paso have successfully mapped specific regions in the brain that are activated in association with changes in blood sugar -; also known as glucose -; providing fundamental location information that could ultimately lead to more targeted therapies for people who struggle with conditions like diabetes.

25 May 2023

$Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride$

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

For pharmaceuticals, knowing the chemical composition is not enough-;molecular geometry and crystal structure also play an important role in a drug's activity.

23 May 2023

Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

22 May 2023

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Pharmaceuticals News and Research

Experts identify a novel fucosylated heparan sulfate from the midgut gland of the Japanese scallop

Study offers a new perspective on the reproductive toxicity of phthalates

'Concerning' CT findings may be an important barrier to discharge of low-risk pulmonary embolism patients

New light-responsive membrane transporters for the translocation of peptide cargos inside cells

Retooling the cell's polypeptide manufacturing plants to generate polymer chains

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Debt deal leaves health programs (mostly) intact

Experimental drug may slow the progression of atherosclerosis

Promising targeted therapy offers new hope to certain patients with advanced pancreatic cancer

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

Study offers the most comprehensive archive of cellular, molecular features involved in psoriatic disease

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Many people living in the ‘diabetes belt’ are plagued with medical debt

High prevalence of galactagogue use among breastfeeding mothers in U.S.

Physical activity in the afternoon provides greatest improvements in glucose control for patients with type 2 diabetes

This panel will decide whose medicine to make affordable. Its choice will be tricky.

Bridging the Gap between Academia and Industry: The Power of Collaboration in Life Sciences

Study maps cellular responses to blood sugar

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

Modified version of anti-nausea drug can enter into cells and provide long-lasting pain relief

Drug Discovery - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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