Pharmacokinetics News and Research

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The term pharmacokinetics is derived from the ancient Greek words “pharmakon” and “kinetikos”, meaning “drug” and “putting in motion” respectively. It is one of the main branches of pharmacology, and refers to the way that the body reacts on and affects a pharmaceutical substance in the body.

A special issue on the emerging COVID-19 infection

Acta Pharmaceutica Sinica B publishes special issue on 'Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)' edited by Hai-Bin Luo, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Shilin Chen, Institute of Chinese Materia Medica, Beijing, China and Peiqing Liu, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

29 Sep 2020

Providing personalized care for bleeding disorders

An interview with Dr. Carmen Escuriola-Ettingshausen MD, Mörfelden-Walldorf, Germany on providing personalized care for bleeding disorders.

From Takeda 21 Sep 2020

Providing personalized care for bleeding disorders

An interview with Dr. Carmen Escuriola-Ettingshausen MD, Mörfelden-Walldorf, Germany on providing personalized care for bleeding disorders.

From Takeda 21 Sep 2020

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefits.

21 Sep 2020

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Using mouse models, scientists have investigated the active plasma metabolite of remdesivir, GS-441 524, and hydroxychloroquine as possible drug candidates in COVID-19. The research shows GS-441 524 could be an effective therapeutic drug against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while at the same time discounting hydroxychloroquine as a reliable anti-viral.

20 Sep 2020

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered ACE2 to enhance its affinity to RBD in human cells.

17 Sep 2020

BioChromato's RAPID Slit Seals offer significant benefits over conventional silicone mats

BioChromato Inc. reports that the pharmacokinetics department at a leading Japanese pharmaceutical company has found that RAPID Slit Seals offer significant benefits compared to conventional silicone mats for maintaining the integrity of microplate samples.

From BioChromato Inc. 17 Sep 2020

NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Materials scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed a new pill which uses the stomach as a drug reservoir and delivers medicines slowly over time to patients with Parkinson's disease (PD).

16 Sep 2020

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Now, a new study by researchers from Pfizer, University of Arizona, Purdue University, The Scripps Research Institute, and UC San Diego School of Medicine and published on the preprint server bioRxiv in September 2020 reports that an enzyme inhibitor may act in synergism with the approved antiviral remdesivir to suppress viral replication in COVID-19.

16 Sep 2020

Circadian rhythm affects SARS-CoV-2 infection and host immune response

In an interesting bioRxiv preprint paper, French researchers show that the time day can affect infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as guide subsequent host immune response – implying that circadian rhythm may well be a novel target for managing viral progression.

14 Sep 2020

Nasal sprays are a known remedy for preventing opioid overdose deaths

Between 250 and 270 people die each year from heroin or opioid overdoses in Norway. In the EU, thousands die. European users now have a better option available for helping each other.

3 Sep 2020

Studying the Proteome and Human Diseases using Mass Spectrometry

An interview with Amanda Hummon, discussing how mass spectrometry can be used to analyze the proteome and how this can help with the study of human disease.

From Pittcon 13 Aug 2020

Simple process could enhance personalization of cancer therapy

Researchers have developed a simplified process that could enhance personalization of cancer therapy based on a single nuclear medicine scan.

12 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

ACTG initiates novel clinical trial to evaluate multiple therapeutics for COVID-19

The AIDS Clinical Trials Group, the world's largest and longest established HIV research network, today announced the initiation of the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial, which will be conducted by the ACTG.

4 Aug 2020

Researchers identify anticoagulation agent that suppresses SARS-CoV-2 replication in vitro

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause acute respiratory distress syndrome, hypercoagulability, hypertension, and multiorgan dysfunction.

27 Jul 2020

Monthly vaginal ring moves one step closer to becoming a new HIV prevention method

A vaginal ring intended to be used for a month at a time has moved one step closer to potentially becoming a new HIV prevention method for cisgender women in sub-Saharan Africa, who despite being the face of the epidemic, have few options for protecting themselves against getting infected.

24 Jul 2020

Eikonoklastes Therapeutics announces closing of oversubscribed seed financing

Eikonoklastes Therapeutics, a preclinical stage biopharmaceutical company developing next-generation tissue factor (TF) immunotherapies for triple-negative breast cancer (TNBC) and several other diseases with unmet clinical need, today announced closing of an oversubscribed seed financing.

23 Jul 2020

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

13 Jul 2020

Newly discovered chemical compound shows potential to become treatment for brain disorders

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism.

11 Jul 2020

Pharmacokinetics News and Research

Further Reading

A special issue on the emerging COVID-19 infection

Providing personalized care for bleeding disorders

Providing personalized care for bleeding disorders

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

Scientists investigate active plasma metabolite of remdesivir in SARS-CoV-2 mouse model

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

BioChromato's RAPID Slit Seals offer significant benefits over conventional silicone mats

NTU-incubated start-up plans clinical trial of new slow-release pill for Parkinson’s disease

Pfizer's anti-viral 3CL protease inhibitor shows antiviral potential against SARS-CoV-2

Circadian rhythm affects SARS-CoV-2 infection and host immune response

Nasal sprays are a known remedy for preventing opioid overdose deaths

Studying the Proteome and Human Diseases using Mass Spectrometry

Simple process could enhance personalization of cancer therapy

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

ACTG initiates novel clinical trial to evaluate multiple therapeutics for COVID-19

Researchers identify anticoagulation agent that suppresses SARS-CoV-2 replication in vitro

Monthly vaginal ring moves one step closer to becoming a new HIV prevention method

Eikonoklastes Therapeutics announces closing of oversubscribed seed financing

New theranostic agents show efficacy for precision diagnosis, treatment of prostate cancer

Newly discovered chemical compound shows potential to become treatment for brain disorders

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

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