Phenotype News and Research

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Discovery of mechanism that protects somatic cells against the behaviour of germ cells

An IRB Barcelona research team discovers the mechanism that favors the correct separation of germ cells -- future ovules and sperm -- from the rest of the cells during embryonic development

3 Aug 2009

Discovery of novel tumor suppressor

La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.

3 Aug 2009

Miglustat shows promise for cystic fibrosis

Miglustat is a drug currently under phase 2 clinical trials on patients suffering from cystic fibrosis (1). Its potential for treating the disease was discovered in 2006 thanks to the work of Frédéric Becq's team at the Institute of Cell Physiology and Biology (CNRS/Université de Poitiers), funded by the associations Vaincre la Mucoviscidose, MucoVie66, La Pierre Le Bigaut and ABCF2.

21 Jul 2009

A new take on growth factor signaling in tamoxifen resistance

Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics, suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling.

23 Jun 2009

Don't stress when the going gets tough - you'll go gray!

A study by Japanese researchers has revealed that a certain kind of stress damages the hair - they say "genotoxic stress" damages DNA by depleting the melanocyte stem cells (MSCs) within hair follicles that are responsible for making the pigment-producing cells.

14 Jun 2009

Genotoxic stress makes your hair go gray

Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the June 12 issue of Cell, a Cell Press publication.

12 Jun 2009

Importance of preventing vascular congestion in heart failure

Preventing vascular congestion is an important mediator in heart failure, reports a study in the June issue of the Journal of Cardiac Failure, published by Elsevier.

4 Jun 2009

Simple stem cell technique restores sight to damaged eyes

In a world-first breakthrough by Australian scientists, the eyesight in a damaged eye has been restored by using stem cells from the eye itself

27 May 2009

Stem cell breakthrough restores sight to sufferers of corneal disease

In a world-first breakthrough, University of New South Wales (UNSW) medical researchers have used stem cells cultured on a simple contact lens to restore sight to sufferers of blinding corneal disease.

27 May 2009

HER2/neu protein predicts development of invasive breast cancer in women with ductal carcinoma in situ

Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study from the University of Pennsylvania School of Medicine.

22 May 2009

Tuberculosis can evade immune response

Current research suggests that Mycobacterium tuberculosis can evade the immune response. The related report by Rahman et al, "Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T cells in the granulomatous lesions," appears in the June 2009 issue of The American Journal of Pathology.

22 May 2009

Scientists develop whole-genome sequencing approach to mapping mutations in fruit flies

The Stowers Institute's Hawley Lab and Molecular Biology Facility have developed a "whole-genome sequencing approach" to mapping mutations in fruit flies.

5 May 2009

Discovery of process that controls T cell growth

Identifying one of the processes that plays a role in naïve and memory T-cells' growth and production could one day lead to better vaccines and possibly more effective cancer immunotherapy, said researchers at Baylor College of Medicine and Texas Children's Hospital in a report that appears in the current edition of Nature Immunology.

3 May 2009

Using combinatorial libraries to engineer genetic circuits advances synthetic biology

Streamlining the construction of synthetic gene networks has led a team of Boston University researchers to develop a technique that couples libraries of diversified components with computer modeling to guide predictable gene network construction without the back and forth tweaking.

22 Apr 2009

Phenotype News and Research

Discovery of mechanism that protects somatic cells against the behaviour of germ cells

Discovery of novel tumor suppressor

Miglustat shows promise for cystic fibrosis

A new take on growth factor signaling in tamoxifen resistance

Don't stress when the going gets tough - you'll go gray!

Genotoxic stress makes your hair go gray

Importance of preventing vascular congestion in heart failure

Simple stem cell technique restores sight to damaged eyes

Stem cell breakthrough restores sight to sufferers of corneal disease

HER2/neu protein predicts development of invasive breast cancer in women with ductal carcinoma in situ

Tuberculosis can evade immune response

Scientists develop whole-genome sequencing approach to mapping mutations in fruit flies

Discovery of process that controls T cell growth

Using combinatorial libraries to engineer genetic circuits advances synthetic biology

Hormone therapy may lower colorectal cancer risk in women

Scientists use RNA to reprogram 1 cell type into another

New clues to how stem cells form

The DECIPHER database - revolutionising clinical practice and genetic research

Missing link between fructose, insulin resistance found

New project to develop blood tests for heart disease and stroke

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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