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Study shows SARS-CoV-2 impairs interferon production through NSP2-induced repression of mRNA translation

Researchers discovered a SARS-CoV-2 non-structural protein 2 (NSP2)-mediated mechanism by which it suppresses the production of interferon-beta (IFN-β) in host cells.

27 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Genomic analysis of the 2022 monkeypox outbreak

In a recent study posted to the bioRxiv* pre-print server, researchers analyzed two genomic sequences of the Monkeypox virus from Belgium and Portugal termed ITM001 and PT0001, respectively, to show that the May 2022 Monkeypox outbreak most likely originated from the West African clade of the virus.

14 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Researchers demonstrated the sarbecovirus open reading frame 7a (ORF7a)-induced hindrance of the antigen presentation by the major histocompatibility complex class I (MHC-I) in hosts.

30 May 2022

Gut microbiota linked to immunocompromised people's variable response to SARS-CoV-2 vaccination

In a recent study posted to the Research Square* preprint server, researchers assessed whether disturbances in the gut microbiota weaken the serological response to the coronavirus disease 2019 (COVID-19) vaccine in inflammatory bowel disease (IBD) patients.

25 May 2022

Addition of left-handed chiral gold nanoparticles can enhance vaccine efficacy by more than 25%

Vaccines can be made over 25% more effective by adding left-handed chiral gold nanoparticles as adjuvants, according to a study by an international collaboration in which Brazilian researchers took part. An article reporting the results is published in Nature.

18 Apr 2022

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

A new study assessed the molecular dynamics of potentially active natural phytochemicals to target the SARS-CoV-2 main protease.

29 Mar 2022

Investigating SARS-CoV-2 detection using Raman microscopy

Researchers investigated the specific intracellular signature of SARS-CoV-2 infection using Raman microscopy.

29 Mar 2022

Researchers characterize vaccines for infectious bronchitis virus

A new study characterized the genetic and immunological aspects of the infectious bronchitis virus (IBV) vaccines commercially used in Korea.

25 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation-; the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Researchers quantified hydrophobic interactions encoded by fusion peptide 1 sequences of SARS-CoV-2 and MERS-CoV using single-molecule force measurements.

10 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

Developing nanoplatforms for direct drug delivery to T cells

T cells, also known as lymphocytes, have important roles in various immune reactions. However, there are only a few reports on delivery systems into T cells. Realizing this, it is essential to work and actively contribute in controlling immune systems.

16 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

A team of scientists from the United States has recently defined the substrate envelop of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server while awaiting peer review.

31 Jan 2022

Phenylalanine News and Research

Study shows SARS-CoV-2 impairs interferon production through NSP2-induced repression of mRNA translation

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Genomic analysis of the 2022 monkeypox outbreak

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Sarbecovirus open reading frame 7a suppresses major histocompatibility complex-I antigen presentation

Gut microbiota linked to immunocompromised people's variable response to SARS-CoV-2 vaccination

Addition of left-handed chiral gold nanoparticles can enhance vaccine efficacy by more than 25%

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

Investigating SARS-CoV-2 detection using Raman microscopy

Researchers characterize vaccines for infectious bronchitis virus

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Quantification of hydrophobic interactions encoded by FP1 sequences of SARS-CoV-2 and MERS-CoV by single-molecule force measurements

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

Developing nanoplatforms for direct drug delivery to T cells

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

A substrate envelope approach to examine drug resistance potential of SARS-CoV-2 Mpro

SARS-CoV-2 virus co-opts intrinsic cellular machinery to suppress interferon production

Applications of bioconjugated nanomaterials in SARS-CoV-2 diagnostics

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

Genetically engineered bacteria can monitor health from within

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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