Phosphatase News and Research

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Researchers use structural biology techniques to understand how lipids bind proteins

Normal cells have a complex system of checks and balances that regulate cell division.

30 Apr 2019

Study finds two new genes in the developmental defects of canine enamel

In addition to humans, hereditary disorders of enamel development occur in dogs, greatly impacting their dental health and wellbeing. A recent study reveals canine enamel disorders similar to those found in humans, linking them with ENAM and ACP4, two genes previously described in humans.

29 Mar 2019

Researchers uncover first spontaneous animal model of human hypophosphatasia

A research group led by Professor Hannes Lohi at the University of Helsinki and Folkhälsan Research Center has uncovered a new skeletal disease in dogs.

30 Jan 2019

Researchers show how mechanical stress affects bone development

Researchers at Okayama University show how mechanical stress at very early stages of bone development alters expression pattern of the non-collagenous matrix responsible for biological property of the bone.

22 Jan 2019

Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli

Researchers from North Carolina State University have developed an artificial enzymatic pathway for synthesizing isoprenoids, or terpenes, in E. coli.

17 Jan 2019

Researchers identify genetic risk factor for atypical heart attack in women

New research published by teams from Leicester, UK and Paris, France in collaboration with international partners from the US and Australia, has found a common genetic factor that confers a significant risk of atypical heart attacks in women.

7 Jan 2019

Research reviews role of protein tyrosine phosphatase in molecular biology

As the proteomics technology develops and human genomic analysis becomes easier to execute, molecules involved in the regulation of biochemical signaling pathways have become interesting subjects for researchers.

28 Dec 2018

Researchers report novel findings on plant hormone

Jasmonic acid is not just the aromatic odor of the plant Jasminum grandiflorum used in cosmetics and perfume industries. Plants wounded by e.g. chewing herbivores produce jasmonic acid as a defense signal, as a phytohormone to mount their defense responses - this includes for example the formation of toxic substances.

10 Dec 2018

Researchers shed light on molecular mechanisms of heart valvular disease

About three per cent of the world's population is affected by valvular heart diseases. It is also the most common cause of heart surgery, as no drug-based treatment is available.

20 Nov 2018

Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord.

20 Nov 2018

Non-coding genetic variant plays key role in endothelial function and disease incidence

Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 people in the United States.

15 Nov 2018

Researchers secure NIH grant to prevent heart disease in chronic kidney disease patients

Researchers at New York Institute of Technology have secured a grant for $391,041 from the National Institutes of Health that may allow for improved understanding of vascular calcification and prevent heart disease in chronic kidney disease patients.

8 Nov 2018

FDA approves LORBRENA for treatment of patients with ALK-positive metastatic NSCLC

Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved LORBRENA, a third-generation anaplastic lymphoma kinase tyrosine kinase inhibitor for patients with ALK-positive metastatic non-small cell lung cancer whose disease has progressed on crizotinib and at least one other ALK inhibitor for metastatic disease; or whose disease has progressed on alectinib or ceritinib as the first ALK inhibitor therapy for metastatic disease.

5 Nov 2018

Potential new biomarkers may aid early detection of glaucoma

Researchers at Ruhr-Universität Bochum have identified new potential biomarkers that may facilitate early detection of glaucoma in patients. Moreover, they ascertained that the mutation of a certain gene in mice causes intraocular pressure elevation.

25 Oct 2018

Study uncovers new mechanism of action in a first-line drug for diabetes

For decades, metformin has been the first-line drug in the treatment of type 2 diabetes, lowering blood glucose levels by inhibiting glucose production in the liver. Metformin also improves glucose uptake and use by muscle tissue.

23 Oct 2018

Computational model helps predict immune response in patients undergoing heart surgery

A research team led by Peter Sloot, professor of Complex Adaptive Systems at the UvA, has managed to pinpoint the mechanisms behind the immune response triggered in patients undergoing open heart surgery.

11 Oct 2018

Pfizer announces FDA approval of VIZIMPRO for first-line treatment of EGFR-mutated metastatic NSCLC

Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved VIZIMPRO [vih-ZIM-pro] (dacomitinib), a kinase inhibitor for the first-line treatment of patients with metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test.

28 Sep 2018

CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer

Takeda Pharmaceutical Company Limited today announced that the European Medicines Agency's Committee for Medicinal Products for Human Use has adopted a positive opinion, recommending the full approval of ALUNBRIG® as a monotherapy for the treatment of adult patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer previously treated with crizotinib.

24 Sep 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

Phosphatase News and Research

Researchers use structural biology techniques to understand how lipids bind proteins

Study finds two new genes in the developmental defects of canine enamel

Researchers uncover first spontaneous animal model of human hypophosphatasia

Researchers show how mechanical stress affects bone development

Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli

Researchers identify genetic risk factor for atypical heart attack in women

Research reviews role of protein tyrosine phosphatase in molecular biology

Researchers report novel findings on plant hormone

Researchers shed light on molecular mechanisms of heart valvular disease

Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Non-coding genetic variant plays key role in endothelial function and disease incidence

Researchers secure NIH grant to prevent heart disease in chronic kidney disease patients

FDA approves LORBRENA for treatment of patients with ALK-positive metastatic NSCLC

Potential new biomarkers may aid early detection of glaucoma

Study uncovers new mechanism of action in a first-line drug for diabetes

Computational model helps predict immune response in patients undergoing heart surgery

Pfizer announces FDA approval of VIZIMPRO for first-line treatment of EGFR-mutated metastatic NSCLC

CHMP adopts positive opinion of Takeda’s ALUNBRIG for treatment of ALK+ non-small cell lung cancer

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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