Phospholipase C News and Research

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Johns Hopkins scientists unravel mystery of retinal cell communication

Working with mammalian retinal cells, neuroscientists at Johns Hopkins Medicine have shown that, unlike most light-sensing cells (photoreceptors) in the retina, one special type uses two different pathways at the same time to transmit electrical "vision" signals to the brain.

25 Jan 2024

IU study sheds new light on the genetic underpinnings of Alzheimer's disease

A groundbreaking study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease.

6 Sep 2023

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Researchers explored the structural basis of agonist specificity of α1A-adrenergic receptors (α1-ARs).

14 Aug 2023

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Cancer cells in an acidic environment undergo lipid synthesis and accumulation, study shows

Alterations in metabolic processes are a hallmark of cancer and can lead to a tumor environment that is acidic. As a result, cancer cells must adapt to survive in this inhospitable environment.

10 May 2022

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

Why do we lose our sense smell/taste with COVID?

The angiotensin-converting enzyme 2 (ACE2) enzyme attached to the membranes of cells is the entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They are abundantly found all over the body and most prominently in the lungs and nose.

28 Apr 2021

Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.

1 Mar 2021

Alzheimer’s disease-associated protective genetic variant enhances key functions of immune cells

A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer's disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer's disease.

25 Sep 2020

Study solves the longstanding mystery of anesthesia

Surgery would be inconceivable without general anesthesia, so it may come as a surprise that despite its 175-year history of medical use, doctors and scientists have been unable to explain how anesthetics temporarily render patients unconscious.

30 May 2020

Lipid signaling from beta cells linked to inflammatory macrophage polarization

Do the insulin-producing beta cells in the pancreas unwittingly produce a signal that aids their own demise in Type 1 diabetes?

23 Feb 2020

Randox unveils innovative test for risk assessment of cardiovascular disease

Global diagnostics company Randox Laboratories has unveiled an innovative new test for the risk assessment of cardiovascular disease at this year's AACC Clinical Lab Expo in Anaheim, California.

26 Jul 2019

Study provides new insights into key beneficial function of small ancient protein

Cell boundaries are made of lipids. When cells are severely damaged, these lipids need to be rapidly removed to avoid toxicity and facilitate tissue healing. Researchers have discovered that a small ancient protein, Serum Amyloid A (SAA), plays a previously unknown key role in this vital process.

21 May 2019

Potential target for Group A Streptococcus vaccine identified

Most people think of "strep throat" as a relatively benign infection cured by a round of antibiotics and a few days of rest. But the bacterium that causes strep throat -- Group A Streptococcus -- is also responsible for a number of much more dangerous disorders, including rheumatic heart disease and toxic shock syndrome.

1 Apr 2019

New study reveals twist in how intoxication happens

As New Year's Eve approaches, many people will experience the familiar buzz that comes from imbibing a favorite cocktail or glass of wine.

27 Dec 2018

Scientists identify ancient light-sensing mechanism in modern mouse retinal cells

Scientists at Johns Hopkins Medicine say they have identified what may be an ancient light-sensing mechanism in modern mouse retinal cells.

9 Nov 2018

Scientists identify molecular pit crew responsible for refueling in signaling cells

During IndyCar races, pit stop crews will often refuel a car, replace wheels and complete minor repairs on a race car within 10 seconds. In this short time, a dozen or so people work rapidly and in a highly coordinated manner to complete a number of tasks with extraordinary efficiency.

24 Aug 2018

New research project investigates alternative treatments for eye infections

Fight for Sight has announced funding for an innovative research project that will investigate whether compounds used to treat snake venom and bee stings could provide an alternative to antibiotics in treating eye infection.

20 Jul 2018

Research project investigates snake venom treatment as antibiotic alternative for eye infections

An innovative University of Liverpool research project that will investigate whether compounds used to treat snake venom and bee stings could provide an alternative to antibiotics in treating eye infection has been awarded £170,000 by the charity Fight for Sight.

19 Jul 2018

Pneumococcal genes predict course of disease

Pneumococcus is an important cause of pneumonia, sepsis and meningitis. This bacterium commonly resides in the nasal cavity.

6 Jul 2018