Phosphorylation News and Research

RSS

Study opens new area of discovery for different aspects of cell biology, biomedical research

Every cell in the body uses phosphorylation, the process of adding a chemical tag to control a protein's function and fate, such as when it moves from one part of a cell to another or binds to other proteins.

19 Jun 2015

UT Southwestern researchers reveal how the body controls glucose transport

UT Southwestern Medical Center scientists have gleaned a key cellular mechanism of how the body adjusts glucose levels, an important process that when abnormal can promote diabetes, cancer, and rare genetic diseases.

10 Jun 2015

Ampio reports effects of Ampion in treating chronic pain caused by osteoarthritis of the knee

Ampio Pharmaceuticals, Inc. today announced three peer-review publications that report the multifaceted and synergistic effects of Ampion in the treatment of osteoarthritis in the knee.

9 Jun 2015

Novel drug target identified for treating rheumatoid arthritis

Researchers at the La Jolla Institute for Allergy and Immunology, in collaboration with colleagues the University of California, San Diego, identified a novel drug target for the treatment of rheumatoid arthritis that focuses on the cells that are directly responsible for the cartilage damage in affected joints.

21 May 2015

Overview of Blueprint Medicines' kinase drug discovery strategy published in JCI

Blueprint Medicines today announced that the Journal of Clinical Investigation published an overview of the Company's kinase drug discovery and development strategy. The publication underscores Blueprint Medicines' focus on identifying novel genomically defined disease drivers and the use of novel chemistry from its proprietary compound library to craft highly selective kinase inhibitors for new and difficult-to-drug kinase targets.

11 May 2015

Quantitative phosphoproteomic approach to identify targeted cancer therapy

Winner of the Louise Eisenhardt Traveling Scholarship Award, Teresa Purzner, MD, presented her research, Quantitative Phosphoproteomics for Targeted Cancer Therapy.

7 May 2015

Discovery of molecular reset button for internal body clock could help treat different disorders

An international team of scientists has discovered what amounts to a molecular reset button for our internal body clock. Their findings reveal a potential target to treat a range of disorders, from sleep disturbances to other behavioral, cognitive, and metabolic abnormalities, commonly associated with jet lag, shift work and exposure to light at night, as well as with neuropsychiatric conditions such as depression and autism.

28 Apr 2015

Calorie restriction can improve muscle metabolism during middle age

Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall health.

23 Apr 2015

U-M researchers make major breakthrough in diagnosing, treating prostate cancer

University of Michigan researchers have discovered a biomarker that may be a potentially important breakthrough in diagnosing and treating prostate cancer.

13 Apr 2015

Mitochondrial DNA movement: an interview with Professor Jiri Neuzil, Griffith University

According to our understanding, mitochondria undergo cycles of fusion-fission, i.e. they divide within the constraints of a cell and, upon cell division, each of the two daughter cells gets its ‘share’ of mitochondria.

29 Mar 2015

Researchers find Pom1 protein regulates different processes of cell growth and division

Investigators from Dartmouth's Norris Cotton Cancer Center led by James Moseley, PhD have found that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division.

24 Mar 2015

Xylem’s YSI biochemistry analyzer is effective tool for cell culture and cancer research

Specifically for oncology drug development applications, the YSI 2950 biochemistry analyzer is used to measure analytes such as glucose, glutamine, glutamate, lactate, providing a simple, automated analysis of bioprocess cell culture samples, with accurate results in less than a minute.

11 Mar 2015

UT Southwestern researchers identify common signaling mechanism that controls immune system

UT Southwestern Medical Center researchers have identified a common signaling mechanism to produce interferon - one of the main proteins used to signal the immune system when the body needs to defend itself against a virus, tumor, or other diseases.

15 Feb 2015

New study provides better understanding of how stem cells give rise to tumors

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers.

6 Feb 2015

Researchers explore KRAS pathway to find potential target for treating lung cancer

Despite the promise of the gene KRAS as a target for treating lung cancer, finding effective therapies has been challenging. Now researchers are traveling down the pathway to find what makes KRAS cancerous.

28 Jan 2015

VE-PTP potential treatment target for retinal and choroidal vascular diseases

Targeting vascular endothelial-protein tyrosine phosphatase, which negatively regulates TIE2 activation, could help to stabilise retinal and choroidal blood vessels, researchers report.

1 Dec 2014

Blocking key brain receptor cell could neutralize biological consequences of Alzheimer's

Blocking a key receptor in brain cells that is used by oxygen free radicals could play a major role in neutralizing the biological consequences of Alzheimer's disease, according to researchers at Temple University.

19 Nov 2014

Cholesterol-fighting statins inhibit uterine fibroid tumors that account for 50% of hysterectomies

Researchers at the University of Texas Medical Branch at Galveston, in collaboration with The University of Texas Health Science Center at Houston (UTHealth), Baylor College of Medicine and the Georgia Regents University, report for the first time that the cholesterol-lowering drug simvastatin inhibits the growth of human uterine fibroid tumors.

16 Nov 2014

Researchers explain interaction between HNRNPA2B1 protein and pancreatic cancer development

Researchers from the University of Barcelona have described an interaction between the protein HNRNPA2B1 and pancreatic cancer development which remained unknown. The study, published in the journal Gastroenterology, has proved in human cancer cell lines that this protein is essential to the correct activity of the oncogenic protein KRAS, related to cancer start and development.

11 Nov 2014

Six research institutions awarded NIH grants to create database of human cellular responses

Building on a successful three-year pilot project, the National Institutes of Health has awarded more than $64 million to six research institutions to create a database of human cellular responses, the Library of Integrated Network-based Cellular Signatures.

15 Sep 2014