Plasmodium falciparum News and Research

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Novel class of sulfonamides to block malaria transmission

Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone. Malaria causes fever and a flu-like illness that occurs when people are infected with the parasite Plasmodium falciparum, which is spread by mosquitoes.

30 Jan 2023

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

A three-dose regimen of a whole-parasite vaccine against malaria – called Plasmodium falciparum sporozoite (PfSPZ) vaccine – demonstrated safety and efficacy when tested in adults living in Burkina Faso, West Africa, which has endemic malaria.

4 Jan 2023

Scientists report the in vitro production of infectious Plasmodium falciparum sporozoites

Scientists from Sanaria Inc., and collaborators at multiple institutions publish results in Nature reporting "In vitro production of infectious Plasmodium falciparum sporozoites."

7 Dec 2022

Laos malaria outbreak in 2020–21 likely caused by multidrug-resistant strains of P. falciparum

Researchers describe the genetic epidemiology and dynamics of the Plasmodium falciparum responsible for malaria outbreaks in Attapeu Province, Laos.

5 Dec 2022

Two experimental mRNA vaccines highly effective in reducing malaria infection and transmission

Malaria is found in more than 90 countries around the world, causing 241 million cases and an estimated 627,000 deaths every year.

1 Dec 2022

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

A new study aimed to evaluate the magnitude, longevity, and prevalence of naturally acquired IgG antibody responses against 9 P. vivax vaccine candidate antigens in patients with acute vivax malaria and were followed up for 180 days.

28 Nov 2022

Monoclonal antibody shows efficacy in preventing malaria infection in African adults

One dose of an antibody drug safely protected healthy, non-pregnant adults from malaria infection during an intense six-month malaria season in Mali, Africa, a National Institutes of Health clinical trial has found.

31 Oct 2022

Novel microfluidic device mimics nutrient exchange between mother and fetus affected by placental malaria

Placental malaria as a consequence of Plasmodium falciparum infections can lead to severe complications for both mother and child.

26 Sep 2022

How frequent was SARS-CoV-2 and malaria co-infection during the first wave of the pandemic?

Researchers determined the prevalence of circulating SARS-CoV-2 variants and the frequency of co-occurrence of COVID-19 and malaria in Burkina Faso, West Africa.

22 Sep 2022

R21/Matrix-M booster maintains high efficacy against first and multiple episodes of clinical malaria

The phase 1/2b clinical trial on R21/Matrix-M malaria vaccine has recently reported the safety and efficacy of booster vaccination at 12 months.

15 Sep 2022

Experimental, genetically attenuated malaria vaccine warrants further exploration

Findings from a preliminary human study of an experimental, genetically attenuated malaria parasite immunization show this vaccine warrants further exploration.

24 Aug 2022

Scientists create a mathematical model to predict genetic resistance to antimalarial drugs

Researchers have created a mathematical model to predict genetic resistance to antimalarial drugs in Africa to manage one of the biggest threats to global malarial control.

12 Aug 2022

New way to test vaccines may be as rigorous and stringent as exposure to field strains of malaria

Malaria is the deadliest mosquito-borne parasitic infection of humans. In 2021, after a century of research, the World Health Organization (WHO) approved the world's first malaria vaccine.

20 Jul 2022

Identifying new chemicals with greater effectiveness, safety than quisinostat

Announcing a new review article publication for Acta Materia Medica journal. In this article the authors use medicinal chemistry methods to identify new chemical entities with greater effectiveness and safety than quisinostat.

17 May 2022

Malaria eradication calls for detection and treatment of asymptomatic cases

Asymptomatic malaria infections do not reduce the risk of severe disease, as widely believed, but suppress the immune system and prevent it from getting rid of parasites that persist in the bloodstream, research suggests.

16 May 2022

Crucial discovery could inform potential strategies to control malaria transmission

WEHI researchers in Melbourne have made a crucial discovery about how asymptomatic malaria infections impact the body, informing potential strategies to control transmission and improve treatment outcomes.

5 May 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022