Positron Emission Tomography (PET) News and Research

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AntiCancer's oral drug overcomes gemcitabine resistance in mouse models of human pancreatic cancer

Pancreatic cancer is lethal in about 95% of cases mostly due to failure of first-line therapy gemcitabine. AntiCancer Inc.'s oral methioninase (AC 00619), which is in late pre-clinical development as an anti-cancer as well as an anti-aging drug, has now been shown to overcome gemcitabine resistance in mouse models of human pancreatic cancer, including AntiCancer's patient-derived orthotopic xenograft mouse models.

25 Jun 2018

AAA doses first patients in two clinical studies with PSMA-R2 for prostate cancer

Advanced Accelerator Applications S.A., a Novartis company and leader in nuclear medicine theragnostics, today announced that the first patients have been dosed in two Phase I/II clinical studies of radiolabeled PSMA-R2, a urea-based ligand of Prostate-Specific Membrane Antigen, which is commonly expressed on prostate cancer cells.

22 Jun 2018

Oxygen consumption in human BAT increases after a meal, shows research

The importance of the human brown adipose tissue has become clearer during the past ten years. Using functional imaging, positron emission tomography, PET, it was possible to show that adult humans have functional BAT.

20 Jun 2018

AFA awards grant to Stony Brook Medicine to improve drug development for Alzheimer's disease

The Alzheimer's Foundation of America is awarding $206,184 over the next three years to Stony Brook Medicine to support an innovative Positron Emission Tomography imaging research project that will compare neurons from healthy controls and those with Alzheimer's disease in an effort to improve drug development.

7 Jun 2018

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

A novel positron emission tomography imaging method shows promise for noninvasively pinpointing sites of inflammation in people with inflammatory bowel disease, which includes ulcerative colitis and Crohn's disease.

4 Jun 2018

Scientists introduce combination approach to fight cancer

For efficient cancer therapy with few side effects, the active drug should selectively attain high concentration in the tumor. In the journal Angewandte Chemie, scientists have introduced a new approach, in which two synergistic drug components are combined into a dimer.

31 May 2018

Scientists develop a new approach for efficient cancer therapy

For efficient cancer therapy with few side effects, the active drug should selectively attain high concentration in the tumor.

30 May 2018

Johns Hopkins researchers identify protein clumps in diseased hearts

Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

9 May 2018

Study provides first ever recording of changing serotonin levels in human brains

Scientists at the Virginia Tech Carilion Research Institute have begun to unravel how serotonin acts, based on data collected in a first-of-its-kind experiment that utilized electrochemical probes implanted into the brain of awake human beings.

3 May 2018

Researchers develop novel theranostic procedure for treating ductal pancreatic adenocarcinoma

German researchers have developed a novel diagnostic and therapeutic (theranostic) procedure for patients with ductal pancreatic adenocarcinoma, a deadly cancer with an extremely poor prognosis (five-year survival rate of less than 5 percent) and limited treatment options. The study is featured in the May issue of The Journal of Nuclear Medicine.

2 May 2018

Sleep deprivation increases brain protein linked to Alzheimer's disease

Losing just one night of sleep led to an immediate increase in beta-amyloid, a protein in the brain associated with Alzheimer's disease, according to a small, new study by researchers at the National Institutes of Health. In Alzheimer's disease, beta-amyloid proteins clump together to form amyloid plaques, a hallmark of the disease.

13 Apr 2018

PET imaging agent may help predict effectiveness of depression treatment

A positron emission tomography imaging agent could show, ahead of time, whether a specific treatment is likely to be effective for major depressive disorder--a debilitating condition that affects more than 14 million Americans.

6 Apr 2018

New blood test can detect early indicators of Alzheimer's disease

There is, as yet, no cure for Alzheimer's disease. It is often argued that progress in drug research has been hampered by the fact that the disease can only be diagnosed when it is too late for an effective intervention.

6 Apr 2018

New PET imaging agent could help guide treatments for people with neurological diseases

Researchers have developed a new imaging agent that could help guide and assess treatments for people with various neurological diseases, including Alzheimer's, Parkinson's, and multiple sclerosis.

2 Apr 2018

Menopausal hormone therapy taken soon after menopause may benefit the brain

Taking menopausal hormone therapy soon after menopause to relieve symptoms may also benefit the brain, according to a study published in the March 21, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology.

22 Mar 2018

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Integrated Diagnostics today announced the e-publication of full results of a large prospective clinical trial validating its Xpresys Lung 2 in the peer-reviewed medical journal CHEST¸ the official journal of the American College of Chest Physicians, titled: Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC trial.

12 Mar 2018

Positron Emission Tomography (PET) News and Research

AntiCancer's oral drug overcomes gemcitabine resistance in mouse models of human pancreatic cancer

AAA doses first patients in two clinical studies with PSMA-R2 for prostate cancer

Oxygen consumption in human BAT increases after a meal, shows research

AFA awards grant to Stony Brook Medicine to improve drug development for Alzheimer's disease

Novel PET imaging shows promise for noninvasively detecting inflammation in people with IBD

Scientists introduce combination approach to fight cancer

Scientists develop a new approach for efficient cancer therapy

Johns Hopkins researchers identify protein clumps in diseased hearts

Study provides first ever recording of changing serotonin levels in human brains

Researchers develop novel theranostic procedure for treating ductal pancreatic adenocarcinoma

Sleep deprivation increases brain protein linked to Alzheimer's disease

PET imaging agent may help predict effectiveness of depression treatment

New blood test can detect early indicators of Alzheimer's disease

New PET imaging agent could help guide treatments for people with neurological diseases

Menopausal hormone therapy taken soon after menopause may benefit the brain

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Researchers develop new method to map dopamine system in Parkinson's patients

UAMS Myeloma Institute expert compiles new book on Castleman disease

Interrupted sleep could be an early sign of Alzheimer’s disease, finds new study

Circadian rhythm disruptions occur much earlier in people at risk of Alzheimer's

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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