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Revolutionary therapeutic shows promise for pancreatic cancer treatment

A new type of investigational therapeutic in development for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the disease, suggesting it has the potential to offer novel treatment options for nearly all pancreatic tumors, a comprehensive study has found.

8 Apr 2024

Burdock roots outshine dandelion in antidiabetic potential study

Study compares the antidiabetic potential of dandelion and burdock roots, finding burdock exhibits higher total phenolic content and α-amylase activity, while dandelion has higher total polysaccharide content, warranting further in vivo studies.

7 Apr 2024

Neural implants face ethical hurdles, study finds

Study delves into the ethical, design, and clinical trial challenges of AI-driven neural implants, highlighting the need for advancements in accuracy, user privacy, and societal acceptance.

7 Apr 2024

Human neuron model identifies potential therapeutic targets for Alzheimer's disease

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain-;a process that drives cognitive decline in Alzheimer's disease and frontotemporal dementia.

5 Apr 2024

Novel combination therapy shows promise in difficult-to-treat endometrial cancer, study finds

In a small, investigator-initiated phase 2 study by Dana-Farber Cancer Institute investigators, a novel combination of an antibody-drug conjugate and an immune checkpoint inhibitor showed notable activity in pre-treated patients with a difficult-to-treat form of endometrial cancer.

5 Apr 2024

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Recombinant adeno-associated virus (rAAV)-based genetic applications to treat human diseases.

5 Apr 2024

Non-invasive detection and treatment of ovarian cancer with new radiotheranostic system

A new radiotheranostic system has the ability to detect and treat ovarian cancer noninvasively, according to new research published in the April issue of The Journal of Nuclear Medicine.

4 Apr 2024

Even moderate alcohol use by pregnant patients may affect babies' prenatal development

University of New Mexico researchers have found that even low to moderate alcohol use by pregnant patients may contribute to subtle changes in their babies' prenatal development, including lower birth length and a shorter duration of gestation.

2 Apr 2024

To ban or not to ban, the case for reformulating ultra-processed foods

Despite concerns about ultra-processed foods (UPFs) and non-communicable diseases (NCDs), evidence of causality remains unclear; reformulating UPFs may offer significant health advantages.

1 Apr 2024

New immunotherapy strategy potentially lays the groundwork for treating autoimmune diseases

Mayo Clinic scientists have developed an immunotherapy strategy that potentially lays the groundwork for treating a spectrum of autoimmune diseases.

1 Apr 2024

Scientists develop trivalent vaccine offering broad protection against coronaviruses

Scientists have been searching for the optimal coronavirus vaccine since the Covid-19 pandemic started.

1 Apr 2024

UC San Diego researchers secure NIH grants to develop noninvasive immune cell imaging technology

Researchers at University of California San Diego School of Medicine have been awarded two new grants by the National Institutes of Health (NIH), totaling $6.7 million, to develop and clinically test technologies that can noninvasively examine and quantify immune cells found in tumors.

1 Apr 2024

New study to test novel psychedelic compound as potential treatment for alcohol use disorder

Modern mental health company Clerkenwell Health announced today that it is working with clinical-stage biotechnology company Beckley Psytech on a Phase IIa study investigating whether a novel psychedelic compound, combined with psychological support, could be an effective treatment for alcohol use disorder (AUD).

29 Mar 2024

An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merck’s WINREVAIR™ (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.

From Sino Biological Inc. 28 Mar 2024

AudioCure Pharma: Novel compound AC102 restores noise-induced hearing loss in preclinical models

A single application of the novel compound AC102 almost completely restores noise-induced hearing loss in preclinical models.

28 Mar 2024

Researchers discover key drivers behind follicular lymphoma's aggressive transformation

A team led by researchers at Weill Cornell Medicine has identified important drivers of the transformation of a type of blood cancer called follicular lymphoma from a slow-growing form to the aggressive form it takes in some patients.

28 Mar 2024

Sensory neurons play pivotal role in orchestrating tissue repair and regeneration

Researchers from Monash University and Osaka University have unveiled a groundbreaking discovery regarding the pivotal role of sensory neurons in orchestrating tissue repair and regeneration, offering significant promise for patients with poorly healing tissues and diabetes.

27 Mar 2024

Drug combination could hold new promise for treating colorectal cancers and other solid tumors

A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published today in Science Advances.

27 Mar 2024

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's.

27 Mar 2024

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

A team of researchers from Columbia University Irving Medical Center and Columbia Engineering has been awarded up to a $38.95 million contract from the Advanced Research Projects Agency for Health (ARPA-H) to build a living knee replacement from biomaterials and human stem cells, including a patient's own cells.

26 Mar 2024

Preclinical News and Research

Revolutionary therapeutic shows promise for pancreatic cancer treatment

Burdock roots outshine dandelion in antidiabetic potential study

Neural implants face ethical hurdles, study finds

Human neuron model identifies potential therapeutic targets for Alzheimer's disease

Novel combination therapy shows promise in difficult-to-treat endometrial cancer, study finds

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Non-invasive detection and treatment of ovarian cancer with new radiotheranostic system

Even moderate alcohol use by pregnant patients may affect babies' prenatal development

To ban or not to ban, the case for reformulating ultra-processed foods

New immunotherapy strategy potentially lays the groundwork for treating autoimmune diseases

Scientists develop trivalent vaccine offering broad protection against coronaviruses

UC San Diego researchers secure NIH grants to develop noninvasive immune cell imaging technology

New study to test novel psychedelic compound as potential treatment for alcohol use disorder

An ActRIIA fusion protein got FDA approved for PAH treatment

AudioCure Pharma: Novel compound AC102 restores noise-induced hearing loss in preclinical models

Researchers discover key drivers behind follicular lymphoma's aggressive transformation

Sensory neurons play pivotal role in orchestrating tissue repair and regeneration

Drug combination could hold new promise for treating colorectal cancers and other solid tumors

Xenotransplantation model used for studying microglial response to Alzheimer's disease

Columbia researchers secure $38.95 million ARPA-H contract to build a living knee replacement

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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