Preclinical Testing News and Research

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Humanized mouse infected with HIV vaginally and rectally allows testing

The "humanized mouse" developed by Dr. J. Victor Garcia-Martinez has allowed the University of Texas Southwestern physician-scientist to conduct HIV/AIDS studies that would have been impossible without such a small animal model of HIV infection.

20 Apr 2009

Chemists synthesize natural alkaloid that could have anti-cancer properties

The club moss Lycopodium serratum is a creeping, flowerless plant used in homeopathic medicine to treat a wide variety of ailments.

15 Apr 2009

Immune-based therapy approved in Europe for pediatric cancer patients

The European Commission, which oversees legislation and regulation for the European Union, has approved a therapy for pediatric patients with non-metastatic, resectable osteosarcoma, a type of bone cancer.

11 Mar 2009

Scientists identify lab-made proteins that neutralize a broad range of influenza A viruses

Scientists have identified a small family of lab-made proteins that neutralize a broad range of influenza A viruses, including the H5N1 avian virus, the 1918 pandemic influenza virus and seasonal H1N1 flu viruses.

23 Feb 2009

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

22 Feb 2009

Lessons from Northwick Park drug-trial disaster

Scientists investigating the 2006 Northwick Park drug-trial disaster that left six healthy volunteers hospitalised say they have developed new pre-clinical tests that could have stopped the trial from ever going ahead.

From The University of Manchester 15 Dec 2008

Concert Pharmaceuticals initiates CTP-347 phase I clinical trial

Concert Pharmaceuticals, Inc. announced today that it has initiated a Phase I study in healthy volunteers to evaluate the safety, tolerability and pharmacokinetics of CTP-347, a novel deuterium-containing serotonin modulator created by Concert researchers.

25 Sep 2008

Inovio Biomedical achieves 75% complete response rate in preclinical testing of DNA-based cancer vaccine using its electroporation DNA delivery system

Inovio Biomedical Corporation announced today that it achieved positive results from its proprietary research and development program for DNA-based cancer vaccines delivered using the company's electroporation-based DNA delivery technology.

15 Sep 2008

New device blocks stomach nerve signals - alternative to existing bariatric surgeries

A new implantable medical device, developed in collaboration with Mayo Clinic researchers, shows promise as a reversible and less extreme alternative to existing bariatric surgeries, according to findings published in the current issue of the journal Surgery.

26 Jun 2008

DNA vaccines boosted by dendritic cells

The concept sounds ideal: vaccines made of DNA that could be taken in by other cells and give instructions for how to fight off different diseases. The reality, however, has fallen short. Although DNA vaccines have been around for about 15 years and shown lots of promise for HIV, SARS and influenza vaccines during preclinical testing in mice, researchers have yet to make them potent enough to be helpful in humans.

18 May 2008

Novel brain cancer drug HhAntag for children may damage bones

A novel drug that fully eliminated brain tumors from mice in a dramatic 2004 study has shown a darker side - causing permanent bone damage in younger mice.

11 Mar 2008

Mouse model tightly matches pediatric tumor syndrome, will speed drug hunt

Frustrated by the slow pace of new drug development for a condition that causes pediatric brain tumors, a neurologist at Washington University School of Medicine in St. Louis decided to try to fine-tune the animal models used to test new drugs.

3 Mar 2008

Purified bacterial extract sprayed into lungs ramps up innate immune system

A purified extract prepared from a common microbe and delivered to the lungs of laboratory mice in a spray set off a healthy immune response and provided powerful protection against all four major classes of pathogens including those responsible for anthrax and bubonic plague, according to a presentation at the American Society for Cell Biology's 47th Annual Meeting.

4 Dec 2007

Severely restricting calories leads to a longer life

New research now has shown for the first time that such a diet also can maintain physical fitness into advanced age, slowing the seemingly inevitable progression to physical disability and loss of independence.

24 Oct 2007

Severely restricting calories leads to a longer life

22 Oct 2007

NanoBio expands drug development team

NanoBio Corporation has announced the addition of four new scientists to its drug development team.

26 Sep 2007

Novel strategy to tackle acute myelogenous leukemia

A novel strategy to hopefully beat into oblivion one of the most aggressive forms of acute myelogenous leukemia combines the strengths of some of the newest leukemia agents, researchers say.

25 Sep 2007

Rapamycin study is first stage in development of new treatment

Rapamycin isn't your ordinary potential anti-cancer drug…It had a long and somewhat exotic history before undergoing preclinical (laboratory-based) studies at St. Jude as part of a national Pediatric Preclinical Testing Program (PPTP) investigation of its anticancer activity.

23 Aug 2007

Handheld BrainScope device detects brain damage immediately after concussion

Researchers at NYU School of Medicine have developed a handheld device that can detect subtle brain damage immediately after concussion.

7 Aug 2007

Huntington's disease study shows animal models on target

An international team of researchers has published a benchmark study showing that gene expression in several animal models of Huntington's Disease (HD) closely resembles that of human HD patients.

1 Aug 2007