Progressive Supranuclear Palsy News and Research

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Cell-hobbling fibrils found across diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

4 Mar 2022

Researchers uncover new findings about the role of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists found that mutant tau impacts the function of mitochondria in human neurons.

20 Jan 2022

Alzheimer's disease develops in a very different way than previously thought

For the first time, researchers have used human data to quantify the speed of different processes that lead to Alzheimer's disease and found that it develops in a very different way than previously thought.

30 Oct 2021

Study may lead to new treatments for a wide range of neurological conditions

New research published today sheds important light on how the production of a key protein in the brain is controlled, which could pave the way for new treatments for a wide range of neurological conditions.

19 May 2021

Study may help to better understand the pathological process involved in brain diseases

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a hallmark of Alzheimer's disease and several other neurodegenerative disorders.

1 Dec 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Nearly $4 million to fund drug discovery research for Alzheimer's, other dementia

The Alzheimer's Association and the Rainwater Charitable Foundation have joined forces again to fund drug discovery research towards finding therapies for Alzheimer's disease, frontotemporal degeneration, and other tauopathies.

4 Mar 2020

Link found between genetic variations and size of the brainstem, other subcortical structures

Researchers have found a link between 48 common genetic variations and the size of the brainstem and other subcortical structures deep within the brain.

21 Oct 2019

New test could detect abnormal forms of protein associated with tauopathies

National Institutes of Health scientists have developed an ultrasensitive new test to detect abnormal forms of the protein tau associated with uncommon types of neurodegenerative diseases called tauopathies.

16 Oct 2019

NIH-funded research consortium aims to advance treatments for frontotemporal lobar degeneration

The National Institutes of Health has awarded a five-year, multi-investigator research grant expected to total more than $63 million to Mayo Clinic and the University of California, San Francisco, to advance treatments for frontotemporal lobar degeneration

16 Oct 2019

Penn researchers to develop critical tool for imaging the brains of patients with Parkinson's

Researchers in the Perelman School of Medicine at the University of Pennsylvania will lead a multi-institutional effort in pursuit of developing a critical tool for imaging the brains of patients with Parkinson's and other neurodegenerative diseases.

10 Oct 2019

Alzheimer's disease attacks brain regions responsible for wakefulness

Researchers and caregivers have noted that excessive daytime napping can develop long before the memory problems associated with Alzheimer's disease begin to unfold.

13 Aug 2019

Excessive daytime sleeping could be an early sign of Alzheimer’s

Excessive daytime napping often develops long before the memory problems associated with Alzheimer's disease occur. Now, researchers may have found the striking new biological explanation for this phenomenon.

12 Aug 2019

Researchers discover early biomarker for degenerative neurologic disease

Researchers have discovered a novel radioligand that can effectively differentiate progressive supranuclear palsy (PSP) from similar brain disorders, allowing for earlier and more reliable diagnosis of the disease.

24 Jun 2019

Scientists develop technique to clear abnormal tau protein from human neurons

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

10 Apr 2019

Scientists find abnormal gene copying in fruit fly models of tauopathies

It sounds like science fiction: Nefarious genes clone themselves and settle their rogue copies in distant outposts of the galaxy (namely, our DNA), causing disease.

24 Jul 2018

Targeting multiple proteins may be key to treat neurodegenerative disorders

Nearly all major neurodegenerative diseases - from Alzheimer's to Parkinson's - are defined and diagnosed by the presence of one of four proteins that have gone rogue: tau, amyloid-beta, alpha-synuclein, or TDP-43.

6 Jul 2018

Mutations found in bassoon gene may help explain cause of rare brain disorder

Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.

23 Mar 2018

AbbVie and Voyager Therapeutics collaborate to develop new treatments for tauopathies

AbbVie, a global biopharmaceutical company, and Voyager Therapeutics, Inc., a clinical-stage gene therapy company, today announced that they have entered into an exclusive strategic collaboration and option agreement to develop and commercialize vectorized antibodies directed against tau for the treatment of Alzheimer's disease and other neurodegenerative diseases.

20 Feb 2018

Scientists find new way to measure tau protein levels in the blood

Damaging tangles of the protein tau dot the brains of people with Alzheimer's and many other neurodegenerative diseases, including chronic traumatic encephalopathy, which plagues professional boxers and football players.

20 Apr 2017