Proliferation News and Research

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Amira to present AM152 preclinical data in fibrotic disease at ATS Annual Meeting

Amira Pharmaceuticals, Inc. announced today that it will present preclinical data on AM152, an LPA1 receptor antagonist, during the Annual Meeting of the American Thoracic Society in Denver, Colorado.

12 May 2011

Treatment with estrogen-lowering drugs shrinks tumors and reduces mastectomy rates in breast cancer patients

In the first large trial of its kind in the United States, researchers have shown that estrogen-lowering drugs can shrink tumors and reduce mastectomy rates for patients with stage 2 or 3 breast cancer.

10 May 2011

Researchers find temperature-sensing protein in immune cells

Researchers at The Scripps Research Institute have found a temperature-sensing protein within immune cells that, when tripped, allows calcium to pour in and activate an immune response.

7 May 2011

Inhalation therapy might halt and reverse progression of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension struggle with severe symptoms, which include shortness of breath, exhaustion and a lack of vitality. Moreover, the disease, which is more common in women, often claims the patient's life within a few years of its development.

6 May 2011

MMRF, APGD collaborate to develop OSI-906 for relapsed multiple myeloma treatment

The Multiple Myeloma Research Foundation and Astellas Pharma Global Development, Inc. today announced that they have entered into a joint collaboration for the clinical development of OSI-906 in patients with relapsed multiple myeloma.

6 May 2011

The Miami Project, InVivo Therapeutics collaborate to develop novel spinal cord injury treatments

InVivo Therapeutics, a company focused on the development of groundbreaking technologies for the treatment of spinal cord injuries, and The University of Miami Miller School of Medicine's Miami Project to Cure Paralysis, the world's most comprehensive spinal cord injury research center, today announced a strategic research collaboration for the development of novel SCI treatments.

5 May 2011

Clinical study: Celecoxib drug may treat breast cancer

The anti-inflammatory drug celecoxib may be a useful additional treatment for people with breast cancer, Dutch researchers report at the IMPAKT Breast Cancer Conference in Brussels.

5 May 2011

Researchers discover new mechanism by which BRCA1 gene mutations can induce breast cancer

Two researchers from the Centre for Genomic Regulation in Barcelona have discovered a new mechanism by which mutations in gene BRCA1 can induce breast cancer.

5 May 2011

MiMedx introduces AmnioFix Nerve Wrap for use in surgical procedures

MiMedx Group, Inc., an integrated developer, manufacturer and marketer of patent protected biomaterial-based products and bioimplants processed from human amniotic membrane, announced today the launch of AmnioFix Nerve Wrap, the Company's latest biologic implant processed to offer surgical and healing options for nerve repair.

5 May 2011

Research: Two-year-old children with autism have enlarged brains

In 2005, researchers from the University of North Carolina at Chapel Hill found that 2-year-old children with autism have brains up to 10 percent larger than children of the same age without autism.

3 May 2011

New PET imaging clinical trial to improve early esophageal, lung cancer detection

Can a simple imaging test help predict the success of cancer treatment, even before the treatment is complete? To begin to answer this question, a new National Cancer Institute-funded clinical trial is using a novel PET imaging technique that could improve the early detection of tumor growth during treatment for esophageal and lung cancer.

29 Apr 2011

Curis reports first quarter net loss of $6.8 million

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today reported its financial results for the first quarter ended March 31, 2011.

28 Apr 2011

New control point for suppressing cancer cell growth

Dana-Farber Cancer Institute scientists have discovered new details of how cancer cells escape from tumor suppression mechanisms that normally prevent these damaged cells from multiplying. They also demonstrated a potential link between this cell proliferation control mechanism and the cognitive deficits caused by Down syndrome.

28 Apr 2011

New discoveries on polycystin-1 can lead to novel kidney disease treatment

Two discoveries at UC Santa Barbara point to potential new drug therapies for patients with kidney disease. The findings are published in this week's issue of the Proceedings of the National Academy of Sciences.

27 Apr 2011

Brain-derived protein in colorectal cancer

Tumor progression is usually ensured by more than one proliferative mechanism. When one of these is shut down by a specifically targeted drug, other mechanisms may emerge. While these events may lead to treatment failure, they may also become an opportunity for researchers to identify novel targets to be further explored.

27 Apr 2011

Signaling pathway reveals mechanism for B cell differentiation in immune response

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells. The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies.

25 Apr 2011

Idera announces delay in commencement of IMO-2125 Phase 2 clinical trial in treatment-naive HCV patients

Idera Pharmaceuticals, Inc. today announced that it has chosen to delay initiating its planned Phase 2 clinical trial of IMO-2125 based on preliminary data from a 26-week nonclinical toxicology study of IMO-2125 in rodents. The Phase 2 clinical trial involves the evaluation of IMO-2125 plus ribavirin in treatment-naïve, genotype 1 hepatitis C virus (HCV) patients.

22 Apr 2011

Valuable insight into immune response

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells.

22 Apr 2011

Coquitlam student earns top prize in 2011 British Columbia SABC competition

Ground-breaking research by a 17-year-old Coquitlam student who found a way to observe the effects of ethanol on early brain development in an intact and awake brain has earned him the top prize in the 2011 British Columbia sanofi-aventis BioTalent Challenge.

22 Apr 2011

Research sheds new light on pathogenesis of diabetes

New research identifies a distinctive population of immune cells that may play a key role in the pathogenesis of diabetes.

22 Apr 2011

Proliferation News and Research

Amira to present AM152 preclinical data in fibrotic disease at ATS Annual Meeting

Treatment with estrogen-lowering drugs shrinks tumors and reduces mastectomy rates in breast cancer patients

Researchers find temperature-sensing protein in immune cells

Inhalation therapy might halt and reverse progression of pulmonary arterial hypertension

MMRF, APGD collaborate to develop OSI-906 for relapsed multiple myeloma treatment

The Miami Project, InVivo Therapeutics collaborate to develop novel spinal cord injury treatments

Clinical study: Celecoxib drug may treat breast cancer

Researchers discover new mechanism by which BRCA1 gene mutations can induce breast cancer

MiMedx introduces AmnioFix Nerve Wrap for use in surgical procedures

Research: Two-year-old children with autism have enlarged brains

New PET imaging clinical trial to improve early esophageal, lung cancer detection

Curis reports first quarter net loss of $6.8 million

New control point for suppressing cancer cell growth

New discoveries on polycystin-1 can lead to novel kidney disease treatment

Brain-derived protein in colorectal cancer

Signaling pathway reveals mechanism for B cell differentiation in immune response

Idera announces delay in commencement of IMO-2125 Phase 2 clinical trial in treatment-naive HCV patients

Valuable insight into immune response

Coquitlam student earns top prize in 2011 British Columbia SABC competition

Research sheds new light on pathogenesis of diabetes

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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