The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.
News-Medical Life Sciences spoke to Nicholas Dupuis from Biognosys at Neuroscience 2019 about proteomics & DIA mass spectrometry in neurodegenerative disease research.
Researchers at the University of Liverpool have made a major breakthrough in the field of cell signalling.
There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.
The study, published recently in Molecular Biology and Evolution, describes the discovery that human saliva is much more watery than the saliva of chimpanzees and gorillas.
The human cell has a wide variety of receptors on its surface that many molecules and therapeutic drugs can bind to in order to activate signals inside the cell to regulate different physiological functions. GPCRs are the largest - and a very important - family of receptors on human cells.
Cells undergo natural aging and death, processes that impact a multitude of cellular factors. A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in the shapes of cellular proteins with age and is a trigger to death.
An estimated 46.6 million U.S. adults struggle with mental illnesses, such as anxiety disorder, according to the National Institute of Mental Health. About half of millennials and 75% of Gen-Zers report having quit jobs for mental health reasons.
Atlas Antibodies AB, a leading supplier of advanced research reagents, announced today the introduction of pre-quantified QPrEST™ Protein Standards for absolute quantification of proteins in biological samples such as cell lysate and plasma using liquid chromatography (LC)–mass spectrometry (MS).
The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have a mutated KRAS gene, or oncogene, that is at least partially responsible for cancer development.
Scientists from Australia’s national science agency, CSIRO, can now detect gluten in any food and show which grain it comes from, making it easier for food companies to correctly label their products.
Many people have wondered whether the gluten-free labeling on their groceries was true. Now, scientists in Australia have come up with a way to identify the presence of specific glutens in rye that indicate the presence of this grain in foods labeled “gluten-free”. Gluten is already known to be present in wheat, barley and oats.
Scientists have discovered hundreds of new protein-protein interactions by looking for co-evolution in some residues of aligned protein sequences.
PhoreMost has entered into an alliance with CCBT in India for the structural visualization of novel druggable sites across multiple targets.
Intermittent fasting is known to improve sensitivity to the blood glucose-lowering hormone insulin and to protect against fatty liver.
PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and C4X Discovery Holdings plc, a pioneering drug discovery company, today announced they have signed a neurodegeneration drug discovery collaboration agreement.
Researchers from the University of Texas Medical Branch at Galveston explain that space travellers often face muscle loss that is caused due to reduced gravity during their flight missions in space. They have found that exercise and certain hormones could help prevent this muscle loss.
"Green revolution" in the early 1950s, the extensive cultivation of Dwarf Rice solves the food problem in developing countries. At present, chronic infection with hepatitis B virus (HBV) has been a major public health problem.
Bruker Daltonics has launched a novel timsTOF fleX mass spectrometer which combines ESI/MALDI capability for SpatialOMx on a single instrument.
Using artificial intelligence, researchers at the Technical University of Munich have succeeded in making the mass analysis of proteins from any organism significantly faster than before and almost error-free.
Scientists from Far Eastern Federal University in cooperation with colleagues from Blokhin Russian Cancer Research Center, Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors.