The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.
Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.
A new blood test has been developed by an international team of scientists which can detect the very early stage of breast cancer.
New research shows that some dietary interventions may not prove effective in helping tackle stress and poor health.
Scientists have shown how cutting-edge methods can be used to catalogue the entire inventory of active proteins in cell organelles at a particular moment. Their work sheds considerable light on how cells use proteins.
When it comes to cell signaling and bioregulation, it's tough to find a more important molecule than nitric oxide (NO). Dysfunction of NO-mediated signaling is thought to be a culprit in lethal cardiovascular conditions such as angina, and septic, cardiogenic and hemorrhagic shock; it may play a role in many other illnesses as well.
As millions of Americans prepare their New Year’s resolutions to lose weight, eat better or exercise more, the University of Michigan Medical School is launching a new center that may help explain why so many resolutions fail, while others succeed.
Microorganisms have potential as living factories for manufacturing drugs and biochemical products. Rapid mass screening methods are needed to identify new species. A new robotic system also provides useful data for genetic engineering.
The chemical industry is going biological: the use of biocatalysts, called enzymes, allows many products to be prepared very efficiently, economically, and in an environmentally safe manner.
Researchers at Wake Forest University School of Medicine and the University of Virginia hope to reset part of the "epigenetic code" in lupus patients and thus improve treatment.
In doing so, they have identified 141 distinct proteins, 99 of which had not been previously recognized in mammalian corneas. The details of their findings appear in the August/September issue of Molecular and Cellular Proteomics, an American Society for Biochemistry and Molecular Biology journal.
Researchers in Japan are developing a faster, more accurate diagnostic test for Sjögren’s (SHOW-grins) syndrome, an incurable autoimmune disorder characterized by chronically dry eyes and dry mouth.
The radical theories about nanobacteria – micro-organisms considerably smaller than ordinary bacteria - in clouds are published in two recent articles in the Journal of Proteome Research by Dr Andrei P. Sommer of the University of Ulm, Germany, and Professor Chandra Wickramasinghe of Cardiff University, UK.
While the United Sates is still the world leader, Europe is having a good deal of success in the field of advanced genomics and proteomics research. Significant government funding together with the presence of large pharmaceutical companies has made Europe a major competitor in the efforts to deploy genomics and proteomics as vital tools in drug discovery and development.
Researchers have identified the largest number of proteins to date in human saliva, a preliminary finding that could pave the way for more diagnostic tests based on saliva samples. Such tests show promise as a faster, cheaper and potentially safer diagnostic method than blood sampling, they say.
Using a basic computer language, the researchers created a "smart" DNA stream that contains a patient's entire medical record
Myriad Genetics has announced that it has been awarded a five-year, $14.2 million contract by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Using conventional technologies, researchers supported by the National Cancer Institute (Science Applications International Corporation-Frederick, Inc. (SAIC)) have developed a new method for identifying proteins found in trace quantities in the blood.
Scientists have believed for decades that the sequencing of the human genome would automatically yield the sequences of proteins, the functional products of genes, and thus lead to the unraveling of the mechanisms behind human cell biology and disease.