Proteomics News and Research

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The term 'proteome' was first coined in 1994, and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.

Luminex launches FDA-cleared xTAG Cystic Fibrosis 60 Kit v2 diagnostic test

Luminex Corporation, the worldwide leader in multiplexed solutions, today announced the full commercial launch of its xTAG Cystic Fibrosis 60 Kit v2, a new diagnostic test that can simultaneously screen a single blood sample for up to 60 cystic fibrosis-causing genetic mutations in a matter of hours.

From Thermo Fisher Scientific Inc. 27 Aug 2010

Scientists create novel map of lipid locations in single cell

In real estate, location is everything. The same might be said of lipids - those crucial cellular fats and oils that serve as building blocks for cells and as key energy sources for the body.In a paper published in the September issue of the Journal of Lipid Research, a team of scientists, led by researchers at the University of California, San Diego School of Medicine, has mapped for the first time the actual locations of specific lipids within a single cell.

26 Aug 2010

Labcyte receives patent for acoustic droplet ejection technology

Labcyte, whose Echo liquid handling platforms move liquids with sound, today announced the grant of its 40th US patent. Patent number 7,717,544 describes how in real time acoustic energy is optimized to transfer a droplet of any fluid, even those that are unknown. Labcyte's acoustic droplet ejection technology offers touchless transfer of a wide variety of fluids, with major benefits in life science applications including drug discovery, genomics, proteomics and diagnostics.

24 Aug 2010

OMICS recommends three-step plan for sustainable advancement and innovation

The U.S. needs a comprehensive and transformational policy for the 21st century to ensure that it remains competitive in the global science and technology arena, according to a provocative opinion piece in the latest issue of OMICS, A Journal of Integrative Biology, a peer-reviewed journal published by Mary Ann Liebert, Inc.

21 Aug 2010

Luminex donates new MAGPIX system to Papua New Guinea Institute of Medical Research

Luminex Corporation, the worldwide leader in multiplexed solutions, today announced it has donated the first commercial unit of its newly launched MAGPIX® instrument to Professor Peter Siba and his scientific team at the Papua New Guinea Institute of Medical Research. The instrument will be used onsite in Papua New Guinea to progress malaria research led by Dr. Peter Zimmerman, Professor of International Health, Genetics and Biology at the Center for Global Health and Diseases at Case Western Reserve University.

From Luminex 18 Aug 2010

Human induced pluripotent stem cells help to treat Parkinson’s disease: Research

Researchers at the Buck Institute for Age Research have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson's Disease (PD). The research, which validates a scalable protocol that the same group had previously developed, can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC's in various biomedical applications. Results of the research, from the laboratory of Buck faculty Xianmin Zeng, Ph.D., are published August 16, 2010 in the on-line edition of the journal Stem Cells.

17 Aug 2010

Scientists use PCT technique to understand physical effects of compression on macromolecules

Scientists are turning to a decades-old technique to better understand the physical effects of compression on macromolecules and how it might impact their research in proteomics, mass spectrometry, protein extraction, and tissue investigations, reports Genetic Engineering & Biotechnology News.

16 Aug 2010

Einstein College receives grant to develop stem cell-based therapies

Scientists at Albert Einstein College of Medicine of Yeshiva University have received a five-year, $10.8 million grant to develop stem cell-based therapies that could be used to mitigate radiation-induced gastrointestinal syndrome - part of acute radiation syndrome (ARS) - for military personnel, first responders and the general public. The Einstein research, funded by the federal Centers for Medical Countermeasures Against Radiation, is part of a program coordinated by the National Institute of Allergy and Infectious Diseases.

12 Aug 2010

GoTaq 2-Step RT-qPCR System allows researchers to detect target genes

The new Promega GoTaq 2-Step RT-qPCR System allows researchers to detect target genes expressed at low levels even with hard-to-amplify samples. Enhanced sensitivity of the two-step system extends the broad dynamic range of RNA quantitation and provides a robust, gene expression analysis tool.

11 Aug 2010

Drugs that reduce activity of ABDH6 enzyme can prevent brain damage: Study

A newly discovered molecular mechanism helps control the amount and effectiveness of a substance that mimics an active ingredient in marijuana, but that is produced by the body's own nerve cells.

7 Aug 2010

Long-term exposure to valproate leads to bone loss: Study

Scientists are reporting a possible explanation for the bone loss that may occur following long-term use of a medicine widely used to treat epilepsy, bipolar disorder, and other conditions. The drug, valproate, appears to reduce the formation of two key proteins important for bone strength, they said. Their study, which offers a solution to a long-standing mystery, appears in ACS' monthly Journal of Proteome Research.

5 Aug 2010

Scientists identify new targets to develop treatment for HD

Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease. These enzymes, matrix metalloproteinases, provide new targets for drug therapies for the disease - targets that have already been shown to respond to cancer drugs currently in clinical development.

29 Jul 2010

Gene expression profiling may provide molecular diagnostic tool to diagnose depression

Blood tests have been extremely important tools aiding doctors in making medical diagnoses and in guiding the treatment of many diseases. However, psychiatry is one area of medicine where there are few diagnostic blood tests.New scientific fields may someday generate blood tests that can be used for these purposes. Some of the areas under increasingly intensive study are genetics, the study of variations in the genes that can be extracted from blood cells, and genomics like proteomics, the measurement of the levels of specific proteins in the blood, and gene expression profiling, which measures the levels of RNA produced from DNA as an indication of the level of the "activity" of particular genes.

23 Jul 2010

SAIC-F selects SAIC-F selects Precision Antibody to provide characterization for reference antibody resource development

Precision Antibody announced today its selection by Science Applications International Corporation-Frederick to provide antibody and antigen characterization, including surface plasmon resonance analysis, for the National Cancer Institute's "Clinical Proteomic Technologies for Cancer" initiative. A goal of the CPTC is to develop a standardized resource of very high-quality, renewable reference antibodies generated against cancer-related proteins. The antibodies will be made available to proteomics researchers, along with characterization data and other information intended to support replication and standardization.

22 Jul 2010

AB SCIEX and ETH partner to accelerate analysis and improve results for metabolomics

AB SCIEX, a global leader in life science analytical technologies, today announced that it is working with scientists at the ETH Zurich Institute of Molecular Systems Biology as part of the Swiss Systems Biology Program (SystemsX.ch) to accelerate analysis and improve results for metabolomics, which is the scientific study of chemical processes involving metabolites.

21 Jul 2010

University of Luebeck becomes part of Metaminer Cardiac Partnership

GeneGo, Inc., a leading provider of databases, software and services in systems biology and chemistry, announced today that Dr. Salah Mohamed in Department of Cardio and Thoracic Vascular Surgery at the University of Luebeck and his team will be part of the Metaminer Cardiac Partnership. Dr. Mohamed is published within 6 different reputed Scientific American Journals in connection with Biomarker Discovery work performed for the American Heart Association.

21 Jul 2010

Biosystems International closes EUR2.1 million funding round

Biosystems International (BSI) SAS, Biotech Leader in the Development of Monoclonal Antibody Based Diagnostics for Cancer, Announced Today That it has Closed a Round of Funding Amounting to EUR2.1 Million ($2.7 Million).

19 Jul 2010

Sumner M. Redstone donates $24M to Keck School of Medicine of USC to support cancer research

The Keck School of Medicine of the University of Southern California has announced a $24 million charitable gift from media executive and philanthropist Sumner M. Redstone. The multi-million dollar gift will support cancer research directed by renowned oncologist David Agus, M.D., professor of medicine at the Keck School of Medicine of USC and director of the USC Center for Applied Molecular Medicine and the USC Westside Prostate Cancer Center.

16 Jul 2010

New findings on macrophage activation can facilitate development of early diagnosis tools

Immune system cells called macrophages spring into action to surround and destroy threats such as viruses or cancer cells. But sometimes the would-be protective response leads to persistent inflammation, which, in turn, can cause disease.Scientists don't know exactly how macrophages cross the line from being good cops to bad cops, but researchers at the University of Florida recently unearthed several clues about the mechanisms involved. Through the lens of two inflammation-related diseases, HIV and rheumatoid arthritis, they identified changes in specific proteins linked to the action of macrophages, white blood cells that are key to the body's natural defenses.

16 Jul 2010

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

Using chemical labeling and mass spectrometry-based techniques, Mark Chance, PhD, director of the Case Western Reserve University School of Medicine Center for Proteomics and Bioinformatics and professor of physiology and biophysics; Sayan Gupta, PhD, instructor at the Case Center for Proteomics and Bioinformatics; and a research team from the University of Oxford, for the first time, were able to take a high resolution picture of the open state of a K+ channel, allowing them to comparatively analyze gating mechanisms important to heart function and nerve signaling - in addition these techniques have already permitted Case Western investigators to gain a deeper understanding of G-protein coupled receptors.

14 Jul 2010

Proteomics News and Research

Further Reading

Luminex launches FDA-cleared xTAG Cystic Fibrosis 60 Kit v2 diagnostic test

Scientists create novel map of lipid locations in single cell

Labcyte receives patent for acoustic droplet ejection technology

OMICS recommends three-step plan for sustainable advancement and innovation

Luminex donates new MAGPIX system to Papua New Guinea Institute of Medical Research

Human induced pluripotent stem cells help to treat Parkinson’s disease: Research

Scientists use PCT technique to understand physical effects of compression on macromolecules

Einstein College receives grant to develop stem cell-based therapies

GoTaq 2-Step RT-qPCR System allows researchers to detect target genes

Drugs that reduce activity of ABDH6 enzyme can prevent brain damage: Study

Long-term exposure to valproate leads to bone loss: Study

Scientists identify new targets to develop treatment for HD

Gene expression profiling may provide molecular diagnostic tool to diagnose depression

SAIC-F selects SAIC-F selects Precision Antibody to provide characterization for reference antibody resource development

AB SCIEX and ETH partner to accelerate analysis and improve results for metabolomics

University of Luebeck becomes part of Metaminer Cardiac Partnership

Biosystems International closes EUR2.1 million funding round

Sumner M. Redstone donates $24M to Keck School of Medicine of USC to support cancer research

New findings on macrophage activation can facilitate development of early diagnosis tools

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

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