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Scientists discover differences in interaction of T-cells within tumor microenvironments

A team led by Northwestern Medicine investigators has discovered differences in the distribution and interaction of T-cells within the microenvironment of different regions of both brain tumors and brain metastases, according to findings published in the journal JCI Insight.

14 Apr 2022

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.

13 Apr 2022

B-cells have significant differences in women with postpartum depression, finds study

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.

10 Apr 2022

Exploring SARS-CoV-2 detection by profiling micro RNAs

A new study analyzed the micro ribonucleic acid profiles in nasal swabs collected from COVID-19 patients.

8 Apr 2022

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Just as asking a single person about their health will provide tailored, personalized information impossible to glean from a large poll, an individual cell's genome or transcriptome can provide much more information about their place in living systems than sequencing a whole batch of cells.

7 Apr 2022

SEACells: an algorithm for identifying metacells

A new study has presented single-cell aggregation of cell-states (SEACells), a graph-based algorithm for identifying metacells.

6 Apr 2022

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Supporting actors sometimes steal the show. In a new study published today in Cell, researchers headed by Prof. Ido Amit at the Weizmann Institute of Science have shown that supporting cells called fibroblasts, long viewed as uniform background players, are in fact extremely varied and vital.

5 Apr 2022

Animal study provides insights into how COVID-19 can lead to long-term pain

A new animal study has provided important insights into how COVID-19 SARS-CoV-2 -; the virus responsible for COVID-19 -; can lead to long-term pain.

4 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Researchers proposed an optimal system to generate SARS-CoV-2 virus-like particles for examining viral assembly and entry into target host cells.

30 Mar 2022

Study reveals a deeper level of cellular heterogeneity within fallopian tubes

The fallopian tube is the site of fertilization, where once a month for the duration of a female's post-pubescent, pre-menopausal life, an egg is moved from the ovary, ready for fertilization by a sperm cell.

29 Mar 2022

Characterization of the different expressed RNAseq variants in SARS-CoV-2 infected patients

A recent study analyzed the RNAseq variants of COVID-19 patients and healthy donors.

29 Mar 2022

New computational approach creates spatial maps of single-cell data within tissues

A new computational approach developed by researchers at The University of Texas MD Anderson Cancer Center successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution.

21 Mar 2022

UT Dallas researchers explore origins of chronic pain and the potential for better treatments

An investigation into how human nerve cells differ from animal cells has provided researchers from The University of Texas at Dallas' Center for Advanced Pain Studies with important clues in the pursuit of more effective treatments for chronic pain.

19 Mar 2022

Study shows BCG vaccination reduces SARS-CoV-2-induced lung inflammation in hamsters

Researchers tested the effectiveness of the BCG vaccine in SARS-CoV-2-infected Syrian hamsters.

18 Mar 2022

Novel oncogenic gene fusions identified in lung and pancreatic cancer

A Yale Cancer Center research team has identified novel oncogenic gene fusions in lung and pancreatic cancer, as well as sarcoma.

16 Mar 2022

Penn State professor receives $2.8 million NIH grant to investigate lower jaw development

How the lower jaw -; mandible -; develops and consequently how and why some developmental birth defects occur is the focus of a five-year, $2.8 million grant to Joan Richtsmeier, distinguished professor of anthropology, Penn State, from the National Institutes of Health's National Institute of Dental & Craniofacial Research.