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Researchers use guide RNAs to improve base editing system

Researchers have used guide RNAs to improve the adenine base editing (ABE) system, used by scientists to alter genetic codes in animal models of disease.

1 Aug 2018

Stabilizing dysfunctional endothelial cells reverses cellular dysfunction in rat model of SVD

Researchers have discovered that stabilizing dysfunctional endothelial cells with approved drugs reverses cellular dysfunction in a rat model of cerebral small vessel disease, hinting towards a new therapeutic approach for the treatment of vascular dementia.

5 Jul 2018

Study suggests new approach for treating alcohol use disorder

Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. The study, published in eNeuro, suggests a new approach towards the treatment of alcohol use disorder.

26 Jun 2018

Preconception binge drinking may have negative effect on future offspring

A rat model found preconception binge drinking may have negative consequences on future offspring's growth, social interactions and pubertal development, according to a new study published in the Endocrine Society's Journal of the Endocrine Society.

19 Jun 2018

Boosting electrical activity in the eye may lead to new treatments for painful dry eye

A boost of electrical activity in the eye's mucous membranes may lead to new treatments for the painful condition known as dry eye.

6 Jun 2018

Researchers seek new approaches to better protect the eye from glaucoma

Under the increased pressure of glaucoma, scientists want to help the neurons in our eyes better protect themselves and get better help from their friends.

29 May 2018

New rat models could be useful in the fight against Alzheimer's disease

Alzheimer's disease currently affects more than 5.5 million Americans and is one of the costliest diseases to treat, according to the Alzheimer's Association. Characterized by a buildup of plaque in the brain, few animal models exist that researchers could use to study this devastating disorder.

30 Apr 2018

Maternal binge drinking may make offspring more vulnerable to mood problems and alcohol abuse

Binge drinking by pregnant and lactating mothers can impair the mental health of their offspring, reports a study published today in Frontiers in Psychiatry.

25 Apr 2018

Non-psychoactive cannabis ingredient could reduce risk of relapse among recovering addicts

A preclinical study in rats has shown that there might be value in using a non-psychoactive and non-addictive ingredient of the Cannabis sativa plant to reduce the risk of relapse among recovering drug and alcohol addicts.

23 Mar 2018

Research reveals neuroprotective mechanisms of gene and cell medications for spinal cord injuries

A joint paper with Kazan State Medical University appeared in Stem Cells International. The research was based at the Gene and Cell Technologies Lab of Kazan University.

8 Mar 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

Decorated cardiac stem cells could provide enhanced treatment for heart attacks

Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging.

10 Jan 2018

Researchers develop novel method to improve delivery of chemotherapy nanodrugs

Carnegie Mellon University researchers have developed a new method for delivering chemotherapy nanodrugs that increases the drugs' bioavailability and reduces side-effects.

29 Nov 2017

Researchers reveal impact of RNA-binding protein on memory formation process

Learning requires the chemical adaptation of individual synapses. Researchers have now revealed the impact of an RNA-binding protein that is intimately involved in this process on learning and memory formation and learning processes.

28 Nov 2017

Investigating new cancer therapy candidates with live-cell imaging

There are two main things that we've worked on in the lab as regards to drug studies. One is identifying new combinations of drugs, and working on why a combination of drugs should work better than each alone.

From Sartorius 16 Oct 2017

Physical stress in preemies plus separation from mothers may have lasting effects into adulthood

A new study suggests that physiological stress in premature infants combined with separation from their mothers may have lasting effects into adulthood.

20 Sep 2017

Adequate sleep and caffeine could help reduce postoperative pain

Sleep is essential for good mental and physical health, and chronic insufficient sleep increases the risk for several chronic health problems.

18 Aug 2017

Study elucidates how aerobic exercise protects the sick heart

Regular exercise is considered an important form of treatment for heart failure, a condition in which the heart is unable to pump enough blood to meet the body's needs.

18 Aug 2017

Researchers uncover novel role for Gata4 in reducing post-heart attack fibrosis

During a heart attack, blood stops flowing into the heart; starved for oxygen, part of the heart muscle dies.

14 Aug 2017

UAB researchers create small molecule that prevents tooth cavities in preclinical model

University of Alabama at Birmingham researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model.

10 Aug 2017