Reactive Oxygen Species (ROS) News and Research

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Study identifies how excess fat disrupts heart cells' ability to produce energy

A University of Iowa study has identified how excess fat in the heart, a common feature in diabetes and obesity, can harm the cells' essential ability to produce energy.

5 Jan 2018

Emerging pharmacologic approach may inhibit NASH

Treating a liver disease called NASH (non-alcoholic steatohepatitis), which affects 10 to 15 percent of obese individuals with type-2 diabetes worldwide, is difficult. But now scientists believe they have found a pharmacologic approach that may inhibit NASH, and thus stop deadly conditions that result from NASH such as cirrhosis and liver cancer.

21 Dec 2017

Researchers show how rhythm of DNA replication can be manipulated to kill cancer cells

Human cells divide and create new cells throughout life. In this process, a steady – even rhythmic – supply of DNA building blocks is needed to create new DNA. Now researchers from the University of Copenhagen are the first to show exactly how human cells regulate this process so it does not fail and cause illness.

10 Nov 2017

Early intervention may be crucial to successful treatment of Friedreich's ataxia

New research published today in Disease Models & Mechanisms indicates that early intervention should be a key target in the development of new therapeutics for Friedreich's ataxia, as current treatments may be administered too late to target the disease effectively.

8 Nov 2017

Pollutant from forest and crop fires induces genetic damage in human lung cells

When exposed in a laboratory to pollution levels comparable to those found in the atmosphere of the Amazon region during the forest and crop burning season, human lung cells suffer severe DNA damage and stop dividing. After 72 hours of exposure, over 30% of the cultured cells are dead.

24 Oct 2017

Northwestern scientists discover 'wasabi receptor' for pain in flatworms

A Northwestern University research team has discovered how scalding heat and tissue injury activate an ancient "pain" receptor in simple animals. The findings could lead to new strategies for analgesic drug design for the treatment of humans.

17 Oct 2017

Plant extracts may help protect against negative effects of X-ray irradiation

A compound found in coriander and ginger may help protect against the negative effects of radiation exposure.

3 Oct 2017

Researchers identify cytotoxic nature of two-dimensional black phosphorous

When environmental and soil chemist Baoshan Xing at the University of Massachusetts Amherst began reading in 2014 that a new, two-dimensional material known as layered black phosphorous (BP) was gaining the attention of biomedical researchers for use in drug delivery systems and tumor photothermal therapy, he was both intrigued and concerned.

31 Aug 2017

Researchers explore freshwater turtles to understand mechanisms that protect from heart damage

In humans, going just minutes without oxygen-;such as during a heart attack or stroke-;can cause devastating damage to the heart.

29 Aug 2017

Study: Liver inflammation increases cholesterol levels in people with diabetes

Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München and the Collaborative Research Center SFB 1118 at Heidelberg University Hospital.

14 Aug 2017

Low doses of radiation exposure linked to increased cardiovascular health risk

Ionizing radiation, such as x-rays, has a harmful effect on the cardiovascular system even at doses equivalent to recurrent CT imaging, a new study published in the International Journal of Radiation Biology suggests.

17 Jul 2017

Researchers synthesize nanoparticles with superior antioxidant properties to treat sepsis

With an incidence of 31.5 million worldwide and a mortality of around 17%, sepsis remains the most common cause of death in hospitalized patients, even in industrialized countries where antibiotics and critical care facilities are readily available.

12 Jul 2017

Research reveals biological processes that underlie comorbidity between Alzheimer's disease and cancer

Patients with Alzheimer's disease have a higher risk of developing glioblastoma and a lower risk of lung cancer.

3 Jul 2017

Pathogen linked to seafood poisoning disarms key host defense system by paralyzing cell's skeleton

The leading cause of acute gastroenteritis linked to eating raw seafood disarms a key host defense system in a novel way: It paralyzes a cell's skeleton, or cytoskeleton.

23 Jun 2017

OIST researchers create taurine-modified photosensitizer for brain cancer therapy

Photodynamic therapy is often used to treat brain tumors because of its specificity—it can target very small regions containing cancerous cells while sparing the normal cells around it from damage. It works by injecting a drug called a photosensitizer into the bloodstream, where it gathers in cells, and then exposing the drug-filled cells to light.

23 Jun 2017

Cryopreservation of Embryos to Improve Assisted Reproductive Technology

If we were to compare the progression of cryopreservation technology during recent years, we would find that from 2004 to 2013 over a timeframe of a decade, there has been around a 2.5 times increase in the rate of frozen-thawed embryo transfers (FETs) that were reported to the Society for Assisted Reproductive Technology (SART). While the rate of fresh embryo transfers (ET) that were completed was the same.

From Sofia Hospital of Obstetrics, Gynecology and Reproductive Medicine 19 Jun 2017

Researchers develop hybrid nanomaterial for destruction of cancer cells

Most tumors contain regions of low oxygen concentration where cancer therapies based on the action of reactive oxygen species are ineffective.

4 May 2017

Scientists develop new processing method to extract valuable biomolecules from wheat bran

It's usually used as livestock feed, but wheat bran's value in human nutrition and medicine may soon reach its full potential with a new sustainable processing method developed by Swedish researchers.

3 May 2017

LIH scientists discover unknown immune activation mechanism to ward off pathogens

Scientists of the Luxembourg Institute of Health have discovered a so far unknown molecular mechanism by which the human immune system activates its immune cells: T cells, a particular type of white blood cells, effectively ward off pathogens if a gene known as Gclc is expressed within them.

19 Apr 2017

Endostatin can decrease proliferation of castration-resistant prostate cancer cells

Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.

10 Mar 2017