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Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages.

26 Mar 2024

AI-based analysis uncovers two plant extracts with potential as GLP-1 agonist weight loss pills

Two plant compounds with potential as GLP-1 agonist weight loss pills have been identified in an AI (artificial intelligence)-based study, the European Congress on Obesity (ECO 2024) (Venice 12-15 May), will hear.

26 Mar 2024

Study reveals trigonelline as a therapeutic agent for mitochondrial dysfunction in aging

Sarcopenia is the age-related decline in skeletal muscle due to the wasting of myofiber.

26 Mar 2024

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

What is currently known about the potential effect of vitamin D (VitD) on modulating some hallmarks of aging.

26 Mar 2024

Vitamin D receptor presence in breast cancer tumors linked to better survival outcomes

Research identifies vitamin D receptors (VDR) in breast cancer tumors as a promising prognostic marker, linking VDR presence to tumor characteristics, survival outcomes, and potentially informing treatment strategies.

25 Mar 2024

Study reveals e-cigarette users with limited smoking history show similar DNA alterations as smokers

A study assessed the effect of tobacco smoking and electronic cigarette (e-cigarettes) use on DNA methylation changes associated with carcinogenesis.

25 Mar 2024

A paramedic was skeptical about this Rx for stopping repeat opioid overdoses. Then he saw it help.

Fire Capt. Jesse Blaire steered his SUV through the mobile home park until he spotted the little beige house with white trim and radioed to let dispatchers know he'd arrived.

25 Mar 2024

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Research highlights the inflammatory impacts of ARDS on the heart, underscoring the role of immune responses in cardiovascular complications from viral infections, including COVID-19, and emphasizes the potential of TNF-α neutralizing therapy to mitigate these effects.

24 Mar 2024

Novel treatment approach to halt epilepsy progression identified

Only a very small percentage of neurons show changes after an epileptic seizure in mice, but these alterations can be permanent and trigger future seizures that can affect the whole brain and lead to impaired cognition, like memory and learning, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

22 Mar 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

Gastric cancer ranks among the most widespread diseases in Asian populations, with South Koreans experiencing the third-highest incidence globally in 2020, as reported by the International Agency for Research on Cancer.

21 Mar 2024

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working.

21 Mar 2024

Exploring the role of iodine in obesity, diabetes, and other metabolic conditions

The metabolic implications of iodine consumption and elucidated the underlying mechanisms.

21 Mar 2024

Lactate's role in driving cancer cachexia uncovered

Study highlights the significant role of lactate in promoting cancer cachexia via activation of the adipose-specific G-protein-coupled receptor 81 (GPR81), suggesting new therapeutic targets for this condition.

20 Mar 2024

Unraveling the relationship between olfactory receptors and blood pressure sex differences

Using data from both mice and humans, a Johns Hopkins Medicine research team has found that a cell surface protein that senses odors and chemicals may be responsible for -; and help explain -; sex differences in mammalian blood pressure.

20 Mar 2024

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy

Researchers have developed a genetic test that can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy drugs.

20 Mar 2024

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status

New data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug, pembrolizumab, to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.

20 Mar 2024

Immune cell protein identified as potential target for rare liver cancer treatment

Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein.

20 Mar 2024

Severity of current SARS-CoV-2 variants is not linked to the number of mutations

New research from UNC Charlotte's Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) has found that the two most prevalent strains of the virus that cause COVID-19, SARS-CoV-2 variants BA.2.86 and JN.1, are not significantly better than their predecessor Omicron at evading immune responses and causing infections despite having a high number of mutations compared to previous variants.

19 Mar 2024

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

Researchers have shown for the first time that a crucial interface in a protein that drives cancer growth could act as a target for more effective treatments.

19 Mar 2024

Receptor News and Research

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

AI-based analysis uncovers two plant extracts with potential as GLP-1 agonist weight loss pills

Study reveals trigonelline as a therapeutic agent for mitochondrial dysfunction in aging

Vitamin D shows promise in targeting aging's biological mechanisms, study finds

Vitamin D receptor presence in breast cancer tumors linked to better survival outcomes

Study reveals e-cigarette users with limited smoking history show similar DNA alterations as smokers

A paramedic was skeptical about this Rx for stopping repeat opioid overdoses. Then he saw it help.

Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Novel treatment approach to halt epilepsy progression identified

Mapping the aging brain's protein landscape

Advancing precision personalized medicine for gastric cancer with 3D bioprinting

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Exploring the role of iodine in obesity, diabetes, and other metabolic conditions

Lactate's role in driving cancer cachexia uncovered

Unraveling the relationship between olfactory receptors and blood pressure sex differences

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status

Immune cell protein identified as potential target for rare liver cancer treatment

Severity of current SARS-CoV-2 variants is not linked to the number of mutations

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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