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Study reveals potential therapeutic targets for treating patients who carry IFNGR receptor mutation

The study began by taking the medical history of 11 children, all of whom had a disorder due to mycobacteria infections, as the basis. All were discovered to have the same phenotype with the same mutation, which was located in the interferon-gamma (IFNGR) receptor, so the group began to explore what was causing this dysfunction.

27 Oct 2016

Study reveals way to actively reverse anesthetic-induced unconsciousness

The latest study from a Massachusetts General Hospital/Massachusetts Institute of Technology team investigating the mechanisms underlying general anesthesia finds that stimulating a specific group of neurons in mice produces signs of arousal -- including getting on their feet and walking -- even as the animals continue to receive the anesthetic drug isoflurane.

27 Oct 2016

Research shows potential way to counteract glioblastoma growth by blocking PPARα receptor

One of the most remarkable features of glioblastoma is the metabolic reprogramming of cancerous cells, resulting in uncontrolled cell proliferation, hypoxic conditions and angiogenesis.

27 Oct 2016

Researchers find link between estrogen levels in lung tissue and SMLA in postmenopausal women

Thanks to advances in medical imaging, the detection rate for synchronous multiple lung adenocarcinoma (SMLA) has been on the rise. Cases of SMLA in Japanese women have been on the rise despite having a national smoking rate of less than 10% in recent years.

26 Oct 2016

Researchers use new gene-editing system to hasten quest to cure HIV+ patients

Researchers at UC San Francisco and the academically affiliated Gladstone Institutes have used a newly developed gene-editing system to find gene mutations that make human immune cells resistant to HIV infection.

26 Oct 2016

Study offers clues to help develop new treatments for cannabis use disorder

A new paper in Biological Psychiatry reports that chronic cannabis users have reduced levels of an enzyme called fatty acid amide hydrolase (FAAH).

25 Oct 2016

Calcium triggers virulence switch from acute to chronic lung infections

The bacterium Pseudomonas aeruginosa is a life-threatening pathogen in hospitals. About ten percent of all nosocomial infections, in particular pneumonia, are caused by this pathogen.

24 Oct 2016

New approach could overcome large immunosuppressive tumors

Harnessing the body's own immune system to destroy tumors is a tantalizing prospect that has yet to realize its full potential. However, a new advance from MIT may bring this strategy, known as cancer immunotherapy, closer to becoming reality.

24 Oct 2016

Screening for prolactin receptor could help improve TNBC prognosis and treatment

A study conducted at the Research Institute of the McGill University Health Centre suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments

24 Oct 2016

TSRI scientists discover reason for lack of successful HCV vaccine design

Researchers have been trying for decades to develop a vaccine against the globally endemic hepatitis C virus (HCV). Now scientists at The Scripps Research Institute have discovered one reason why success has so far been elusive.

24 Oct 2016

International scientists create first 3D atomic-level image of human cannabinoid receptor 1

In a discovery that advances the understanding of how marijuana works in the human body, an international group of scientists, including those from the Florida campus of The Scripps Research Institute (TSRI), have for the first time created a three-dimensional atomic-level image of the molecular structure activated by tetrahydrocannabinol (THC), the active chemical in marijuana.

24 Oct 2016

New study examines how tumor genome testing helps improve breast cancer treatment

A new study examines how one early example of precision medicine--tumor genome testing--is being used in women with breast cancer to reduce overtreatment and maximize the benefits of chemotherapy.

24 Oct 2016

RAC1 protein plays crucial role in proper development of mammalian lung

A study by researchers from The Saban Research Institute of Children's Hospital Los Angeles reveals a promising therapeutic target for improving lung function in infants.

21 Oct 2016

Researchers identify genomic regions linked to ulcerative colitis in African-Americans

In the first genome-wide association study of genetic risk factors for inflammatory bowel disease in African Americans, a research team has identified two regions of the genome (loci) associated with ulcerative colitis only in people of African descent.

20 Oct 2016

Yale researchers identify chemical inhibitor that limits growth of lung tumor cells

A recently published Yale study may offer a new solution to fighting lung cancer.

20 Oct 2016

Scientists use new technique to improve accuracy of detecting protein microcrystals

In a collaborative study, scientists from MIPT and JINR (Joint Institute for Nuclear Research) have increased the accuracy of detecting valuable protein crystals measuring just a few microns.

20 Oct 2016

Gene variants linked to hot flashes in menopausal women

Most women experience hot flashes and night sweats either before or during menopause, but a significant minority don't have these symptoms. Could our genes be a factor in determining which women get hot flashes?

19 Oct 2016

FDA approves new therapy for initial treatment of soft tissue sarcoma

The U.S. Food and Drug Administration today granted accelerated approval to Lartruvo (olaratumab) with doxorubicin to treat adults with certain types of soft tissue sarcoma (STS), which are cancers that develop in muscles, fat, tendons or other soft tissues.

19 Oct 2016

Study identifies factors that increase risk for breast cancer in young African American women

Black women under the age of 45 are at increased risk for an aggressive form of breast cancer [estrogen receptor (ER) negative] if they experienced a high number of pregnancies, never breast fed, and/or had higher waist-to-hip ratio.

19 Oct 2016

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease.

19 Oct 2016

Receptor News and Research

Study reveals potential therapeutic targets for treating patients who carry IFNGR receptor mutation

Study reveals way to actively reverse anesthetic-induced unconsciousness

Research shows potential way to counteract glioblastoma growth by blocking PPARα receptor

Researchers find link between estrogen levels in lung tissue and SMLA in postmenopausal women

Researchers use new gene-editing system to hasten quest to cure HIV+ patients

Study offers clues to help develop new treatments for cannabis use disorder

Calcium triggers virulence switch from acute to chronic lung infections

New approach could overcome large immunosuppressive tumors

Screening for prolactin receptor could help improve TNBC prognosis and treatment

TSRI scientists discover reason for lack of successful HCV vaccine design

International scientists create first 3D atomic-level image of human cannabinoid receptor 1

New study examines how tumor genome testing helps improve breast cancer treatment

RAC1 protein plays crucial role in proper development of mammalian lung

Researchers identify genomic regions linked to ulcerative colitis in African-Americans

Yale researchers identify chemical inhibitor that limits growth of lung tumor cells

Scientists use new technique to improve accuracy of detecting protein microcrystals

Gene variants linked to hot flashes in menopausal women

FDA approves new therapy for initial treatment of soft tissue sarcoma

Study identifies factors that increase risk for breast cancer in young African American women

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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