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Scientists aim to understand why T cells do not sustain energy in tumors

T cells are often called "assassins" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body.

15 Mar 2024

CHOP study uncovers metabolic key to faster immune response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

15 Mar 2024

Research provides insight into how the brain translates motivation into goal-oriented behavior

Hunger can drive a motivational state that leads an animal to a successful pursuit of a goal -; foraging for and finding food.

15 Mar 2024

Eating fatty food before surgery may affect memory-related cognitive function in older adults

Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults.

15 Mar 2024

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Adhesion GPCRs belong to the large family of G protein-coupled receptors (GPCRs). There are about 700 variants in humans, which are responsible for sensory impressions, hormonal cycles, controlling the cardiovascular system and more.

15 Mar 2024

Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

15 Mar 2024

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth

Breakthrough in Brain Cancer Treatment: Dual-Target CAR T Cell Therapy Shows Promise in Early Clinical Trial.

15 Mar 2024

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

14 Mar 2024

Anti-inflammatory gene variant shields men under 75 from severe COVID-19

A certain variant of a key anti-inflammatory gene protects men under age 75 from severe illness and death when hospitalized from COVID-19, a genetic analysis of their blood shows.

14 Mar 2024

Age-related changes in the shape of brain neurons lead to middle-age obesity

Nagoya University researchers and their colleagues in Japan have found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region of the brain that controls metabolism and appetite.

13 Mar 2024

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Researchers identify potential new approaches for early detection and treatment of atherosclerosis

Blockage of arterial blood vessels caused by atherosclerosis is largely responsible for heart attacks and strokes, which are the most common causes of death worldwide.

13 Mar 2024

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.

13 Mar 2024

Improving iron status in young girls: The impact of iron-fortified lentil consumption

The effectiveness of integrating iron-fortified lentils (IFLs) into female diets.

13 Mar 2024

New custom-designed proteins can efficiently reach intramembrane targets

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently reach these "intramembrane" targets.

13 Mar 2024

Receptor News and Research

Scientists aim to understand why T cells do not sustain energy in tumors

CHOP study uncovers metabolic key to faster immune response

Research provides insight into how the brain translates motivation into goal-oriented behavior

Eating fatty food before surgery may affect memory-related cognitive function in older adults

Newly discovered adhesion GPCR mayo controls midgut development in Drosophila

Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Anti-inflammatory gene variant shields men under 75 from severe COVID-19

Age-related changes in the shape of brain neurons lead to middle-age obesity

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Researchers identify potential new approaches for early detection and treatment of atherosclerosis

Researchers discover diverse and spatially coordinated cardiac cells involved in heart development

Improving iron status in young girls: The impact of iron-fortified lentil consumption

New custom-designed proteins can efficiently reach intramembrane targets

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Study highlights potential therapeutic target for immune-related disorders

Choosing the right fat for keto diets: Fish oil's significant role in cancer prevention

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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