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Study reviews natural drug candidates for potential treatment of COVID-19

A recent paper in the Saudi Journal of Biological Sciences seeks to open up new approaches by reviewing a list of compounds derived from plants and other natural sources, which have potential inhibitory activity against the coronavirus.

21 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

Western diet increases COVID-19 severity in a hamster model

Researchers have shown that a Western diet may affect viral replication, disease severity, and immune protection following infection with SARS-CoV-2.

21 Jun 2021

Researchers identify four substances that inhibit SARS-CoV-2 replication in cells

Researchers from the German Center for Infection Research at Charité - Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage.

21 Jun 2021

COVID-19 studies should provide sex-disaggregated data, researchers warn

Researchers have warned that studies examining sex-specific responses to infection with SARS-CoV-2 must provide sex-disaggregated data.

21 Jun 2021

Research identifies SARS-CoV-2 cavities as potential drug targets

New research found the SARS-CoV-2 spike glycoprotein has druggable cavities with the best target being compatible with more than 1 billion compounds.

21 Jun 2021

Can a prior rhinovirus infection protect against COVID-19?

Researchers at the Yale School of Medicine found that rhinovirus accelerates interferon-stimulated genes.

21 Jun 2021

Study shows activation of CD16+ T-cells contribute to severe COVID-19 illness

Do T-cells play a protective immune role, or are they responsible for severe COVID-19 illness?

21 Jun 2021

Zinc inhibits SARS-CoV-2’s main protease in vitro

Zinc has antiviral properties. However, the detailed kinetics and the mechanism of zinc in the inhibition of viruses, particularly SARS-CoV-2 – the causative virus of COVID-19 – is unclear. To probe the role of zinc as an anti-SARS-CoV-2 agent at the structural and molecular level, researchers in India studied the binding kinetics and the inhibition mechanism of zinc with SARS-CoV-2’s viral proteins.

21 Jun 2021

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

In a recent study, a group of researchers aimed to identify exactly how early SARS-CoV-2 was circulating throughout the United States.

21 Jun 2021

Anti-coronavirus molecules from microbes could be key to new treatments

Microbes in the gut that produce beneficial compounds could hold the key to treating coronavirus symptoms.

21 Jun 2021

Effects of COVID-19 infection persist in patients even post-treatment

Patients infected by COVID-19 suffer cognitive and behavioral problems lasting even 2 months post-hospital release.

21 Jun 2021

Can convalescent plasma therapy improve COVID-19 outcomes in patients with hematologic cancers?

A recent study discusses the findings of a study on patients with hematologic cancers who received convalescent plasma therapy following their diagnosis of COVID-19.

21 Jun 2021

Combination of doxycycline and TB drug treatment reduces the size of lung cavities

Globally, an estimated 10 million people develop tuberculosis (TB) each year and the disease remains a leading cause of death from a single infectious agent. Standard short-course anti-TB treatment still requires a regimen of at least six months of antimicrobial drugs, and drug-resistant TB is an increasing public health threat.

21 Jun 2021

COVID-19 patients suffer from cognitive, behavioral problems after discharge, study finds

COVID-19 patients suffer from cognitive and behavioral problems two months after being discharged from hospital, a new study presented at the 7th Congress of the European Academy of Neurology (EAN) has found.

21 Jun 2021

Study: Patients with two SARS-CoV-2 variants are less likely to be asymptomatic compared to control group

Although two SARS-CoV-2 variants are associated with higher transmission, patients with these variants show no evidence of higher viral loads in their upper respiratory tracts compared to the control group, a Johns Hopkins School of Medicine study found.

21 Jun 2021

Respiratory News and Research

Study reviews natural drug candidates for potential treatment of COVID-19

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

Western diet increases COVID-19 severity in a hamster model

Researchers identify four substances that inhibit SARS-CoV-2 replication in cells

COVID-19 studies should provide sex-disaggregated data, researchers warn

Research identifies SARS-CoV-2 cavities as potential drug targets

Can a prior rhinovirus infection protect against COVID-19?

Study shows activation of CD16+ T-cells contribute to severe COVID-19 illness

Zinc inhibits SARS-CoV-2’s main protease in vitro

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

Anti-coronavirus molecules from microbes could be key to new treatments

Effects of COVID-19 infection persist in patients even post-treatment

Can convalescent plasma therapy improve COVID-19 outcomes in patients with hematologic cancers?

Combination of doxycycline and TB drug treatment reduces the size of lung cavities

COVID-19 patients suffer from cognitive, behavioral problems after discharge, study finds

Study: Patients with two SARS-CoV-2 variants are less likely to be asymptomatic compared to control group

Novel technique helps evaluate the effect of potential inhibitors on antibiotic-resistant bacteria

Our commitment to a more sustainable future

New technique can measure metabolic process at the single-cell level

Could a fungus-derived compound reduce hyperinflammation in severe COVID-19?

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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