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DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen.

23 Apr 2021

COVID-19 survivors have increased risk of death for at least six months

As the COVID-19 pandemic has progressed, it has become clear that many survivors -; even those who had mild cases -; continue to manage a variety of health problems long after the initial infection should have resolved.

23 Apr 2021

Celastrol shows potential anti-SARS-CoV-2 activity

A new study published on the bioRxiv* preprint server focuses on the in-silico predictions to repurpose existing drug compounds, that may have the ability to reverse the SARS-CoV-2 gene expression induced in host cells.

23 Apr 2021

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Preclinical study from NIH/Moderna: Correlates of SARS-CoV-2 immunity in non-human primates

Researchers in the United States have shown that the antibody response induced by the Moderna mRNA-1273 vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a correlate of immune protection against coronavirus disease 2019 (COVID-19) in non-human primates.

22 Apr 2021

Slow COVID-19 vaccine rollout in Tokyo could mean no Olympic and Paralympic Games

Researchers in Japan have warned that Tokyo's Olympic and Paralympic Games, which is set to start in July 2021, may need canceling if the rollout of vaccination to protect against coronavirus disease 2019 (COVID-19) continues at the slow pace it is now.

22 Apr 2021

Respiratory symptoms more likely to develop when people use both e-cigarettes and tobacco cigarettes

Exclusively using (or "vaping") e-cigarettes can help people quit smoking, but many people using e-cigarettes to quit smoking continue to smoke cigarettes.

22 Apr 2021

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure.

22 Apr 2021

House flies can carry SARS-CoV-2 up to 24 hours after exposure, study finds

A team of researchers in the USA – at Kansas State University and Agricultural Research Service – found that house flies can acquire and harbor infectious SARS-CoV-2 for up to 24 hours after exposure.

22 Apr 2021

How effective is the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine? A real-world study in Sweden

Investigating a population in southern Sweden, a new study has found that a single dose of the vaccine is only about 42% effective in preventing coronavirus disease 2019 (COVID-19). But seven days after the second dose, the vaccine can prevent COVID-19 in 86% of the population.

22 Apr 2021

Doctors scramble to understand long Covid, but causes and prognosis are elusive

One night in March 2020, Joy Wu felt like her heart was going to explode. She tried to get up and fell down. She didn't recognize friends' names in her list of phone contacts. Remembering how to dial 9-1-1 took "quite a bit of time," she recalled recently.

22 Apr 2021

Researchers conduct a SARS-CoV-2 serosurvey of blood donors in New Zealand

New research has been released, which focuses on the transmission and prevalence of SARS-CoV-2 in New Zealand, through a blood donor serosurvey.

22 Apr 2021

Researchers aim to better understand clinical features associated with COVID-19 mortality

To better understand the COVID-19 clinical feaures associated with mortality, an interdisciplinary team of researchers has investigated important factors and their influence on a patient’s death.

22 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

Metabolic testing of COVID-19 patients through skin imprints

There is, therefore, a great need to understand how the illness can be diagnosed using more convenient and inexpensive methods. A new study posted to the medRxiv preprint server reveals the potential role of skin imprints to test for biomarkers that indicate a diagnosis of COVID-19 in a non-invasive way.

22 Apr 2021

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Researchers in the United States have developed adenovirus vectors that may be more effective at generating immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those used in the vaccines that are currently being rolled out to help combat the coronavirus disease 2019 (COVID-19) pandemic.

21 Apr 2021

Maintaining swimming pools in line with UK guidelines eliminates SARS-CoV-2 risk

Researchers in the UK have conducted a study showing that maintaining swimming pool water in accordance with UK guidelines is sufficient to eliminate the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) being transmitted between bathers.

21 Apr 2021

Respiratory News and Research

DNA vaccine candidate induces potent immunity, offers protective efficacy in non-human primate models

COVID-19 survivors have increased risk of death for at least six months

Celastrol shows potential anti-SARS-CoV-2 activity

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Preclinical study from NIH/Moderna: Correlates of SARS-CoV-2 immunity in non-human primates

Slow COVID-19 vaccine rollout in Tokyo could mean no Olympic and Paralympic Games

Respiratory symptoms more likely to develop when people use both e-cigarettes and tobacco cigarettes

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

House flies can carry SARS-CoV-2 up to 24 hours after exposure, study finds

How effective is the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine? A real-world study in Sweden

Doctors scramble to understand long Covid, but causes and prognosis are elusive

Researchers conduct a SARS-CoV-2 serosurvey of blood donors in New Zealand

Researchers aim to better understand clinical features associated with COVID-19 mortality

Some COX inhibitors/NSAIDs increase COVID-19 severity

Metabolic testing of COVID-19 patients through skin imprints

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Maintaining swimming pools in line with UK guidelines eliminates SARS-CoV-2 risk

Argonne's Advanced Photon Source guided the development of new COVID-19 vaccine now in trials

Study investigates the prevalence of COVID-19 symptoms among immunocompromised children

Interfering RNA nanoparticles could be a potential COVID-19 therapy

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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