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Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Researchers have investigated the effectiveness of a bioengineered miniprotein in protecting against SARS-CoV-2 infection in vivo. The researchers evaluated the miniprotein, LCB1, against SARS-CoV-2-mediated lung disease in human ACE2-expressing transgenic mice.

3 Mar 2021

Obesity may reduce COVID-19 vaccine efficacy, say researchers

A startling indicates that obesity may reduce the immune response to the current COVID-19 vaccines, along with other factors like age and sex. This could have significant implications for vaccination strategies in obese people.

3 Mar 2021

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

An interesting new preprint shows that even if countries are forced to delay the second dose of the current vaccines administered against SARS-CoV-2, to arrest the ongoing COVID-19 pandemic, the cumulative mortality would still fall significantly.

3 Mar 2021

Researchers conduct large meta-analysis of COVID-19’s neurological manifestations

The global spread of the COVID-19 pandemic, caused by SARS-CoV-2, has led to intense interest in the various manifestations of the infection, including its neurological features. A compact summation by researchers across the UK of what is known at present about this facet of the disease is presented in a new paper.

3 Mar 2021

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

A new study by researchers at the University of California, San Francisco, discusses the different aspects of long-term immune responses in a wide sample of patients, as well as how they vary in clinical severity and sequelae.

3 Mar 2021

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

A new study by researchers at Mahidol University in Bangkok, Thailand, reports a COVID-19 vaccine candidate called HexaPro in producing neutralizing antibodies against the SARS-CoV-2 spike protein in an animal model.

3 Mar 2021

Combination of therapies may benefit patients with mitochondrial respiratory chain disorders

Researchers from the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders.

3 Mar 2021

Severe complication of COVID-19 in children reveals distinct features of virus

A new study of patients with Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but severe complication of COVID-19 in children, reveals distinct immune features of COVID-19 not seen in adults that may clue scientists in to why SARS-CoV-2 infection manifests differently in children compared with adults.

3 Mar 2021

New tool can define how infectious pathogens transport in the air

In the 1995 movie "Outbreak," Dustin Hoffman's character realizes, with appropriately dramatic horror, that an infectious virus is "airborne" because it's found to be spreading through hospital vents.

3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Study demonstrates long-term neuropsychological consequences following SARS-CoV-2 infection

The study, published in the pre-print server medRxiv, demonstrates the presence of long-lasting neuropsychological sequelae after COVID-19, regardless of the respiratory disease's severity.

2 Mar 2021

SARS-CoV-2 viremia predicts severe COVID-19 disease outcomes

The SARS-CoV-2 plasma viremia has been linked to severe disease and death in COVID-19 cases in small-scale cohort studies. The current study, published on the pre-print server medRxiv, aimed to study the mechanisms behind this relationship.

2 Mar 2021

Early antibody response predicts COVID-19 outcome

To address this gap, researchers from the U.S. evaluated the timing of antibody production against SARS-CoV-2 in hospitalized patients. They used a highly sensitive multiplexed bead-based immunoassay that allows for early detection of anti-SARS-CoV-2 antibodies. The study is published on the preprint server medRxiv.

2 Mar 2021

Quantifying SARS-CoV-2 viral load in hospitalized patients

A new paper, published on the medRxiv preprint server, investigates the role of subgenomic RNA transcripts in SARS-CoV-2 infection. Earlier, scientists believed that subgenomic RNA could be traceable infective markers to monitor infectivity.

2 Mar 2021

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Researchers at the New York State Department of Health in the United States have said concerning mutations within the B.1.526 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently become prevalent in New York State warrant further monitoring.

2 Mar 2021

Survey reveals impact of Pfizer-BioNTech vaccination in the UK

Researchers at Imperial College London in the UK have reported on round five of the REal-time Assessment of Community Transmission-2 (REACT-2) program – a cross-sectional community survey measuring the prevalence of antibodies against the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among adults in England.

2 Mar 2021

Children with MIS-C have highly activated immune systems, study finds

Taking the first deep dive into how the immune system is behaving in patients with multisystem inflammatory syndrome in children (MIS-C), researchers at Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania have found that children with this condition have highly activated immune systems that, in many ways, are more similar to those of adults with severe COVID-19.

2 Mar 2021

Respiratory News and Research

Researchers develop ultrapotent miniproteins that target SARS-CoV-2 receptor-binding domain

Obesity may reduce COVID-19 vaccine efficacy, say researchers

Delayed second dose strategy with mRNA vaccines may reduce COVID-19 mortality, say researchers

Researchers conduct large meta-analysis of COVID-19’s neurological manifestations

Researchers examine long-term immune responses following COVID-19 across clinically diverse cohort

Novel SARS-CoV-2 spike vaccine candidate produces strong neutralizing response in vivo

Combination of therapies may benefit patients with mitochondrial respiratory chain disorders

Severe complication of COVID-19 in children reveals distinct features of virus

New tool can define how infectious pathogens transport in the air

How SARS-CoV-2 proteins affect vascular functionality

Study demonstrates long-term neuropsychological consequences following SARS-CoV-2 infection

SARS-CoV-2 viremia predicts severe COVID-19 disease outcomes

Early antibody response predicts COVID-19 outcome

Quantifying SARS-CoV-2 viral load in hospitalized patients

Concerning mutation in New York SARS-CoV-2 should be monitored, warn researchers

Survey reveals impact of Pfizer-BioNTech vaccination in the UK

Children with MIS-C have highly activated immune systems, study finds

Readers and tweeters dispense timely advice for difficult times

Could small synthetic antigen proteins be diagnostic tools for SARS-CoV-2?

Evonik partners with BioNTech to manufacture lipids for COVID-19 vaccine

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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