Reverse Transcriptase News and Research

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Knowledge of HIV Pol polyprotein's structure could spur the development of new therapies

In a discovery that could spur the development of new therapies for more than 40 million HIV patients worldwide, scientists from Rutgers University and the Salk Institute determined the molecular structure of the HIV Pol polyprotein, a protein that plays a critical role in helping the virus propagate itself and spread throughout the body.

7 Jul 2022

Acute scrotal infections among COVID-19 patients significantly associated with disease severity in new study

In a new study, researchers assessed the influence of severe coronavirus disease 2019 on scrotal infections.

5 Jul 2022

Crystal structure of a human endogenous reverse transcriptase revealed

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and other diseases, according to a study co-authored by a Rutgers researcher.

30 Jun 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

Serologic testing captures missed children at risk for long Covid

A new study provides evidence of the utility of serologic testing in helping to pick up children with long Covid following missed diagnoses of COVID-19.

24 Jun 2022

Demonstrating varying pathogenicity and tropism of SARS-CoV-2 variants in a feline model

In a recent study posted to the bioRxiv* pre-print server, researchers at Cornell University College of Veterinary Medicine and the University of Illinois Urbana-Champaign compared the infection dynamics, pathogenicity, and tissue tropism of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in adult cats.

17 Jun 2022

Nasopharyngeal microbiota influences SARS-CoV-2 infection status and severity

In a recent study posted to the medRxiv* pre-print server, Canadian researchers investigated how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection altered the microbiota composition of the host’s nasopharyngeal region.

16 Jun 2022

Co-circulation of adenovirus 40/41 and SARS-CoV-2 and emergence of hepatitis cases in children

In a recent study posted to the medRxiv* pre-print server, KU Leuven researchers investigated whether there was an association between the intensity of the co-circulation of adenovirus (AdV) 40/41 and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the number of hepatitis cases of unknown origin emerging in Belgium.

12 Jun 2022

Study finds Moderna COVID vaccine efficacy peaks at 94% after 120 days

A recent research letter posted to the JAMA Network Open assessed the durability of immunity conferred by the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA)-1273 vaccine.

10 Jun 2022

Two cases of MIS-C after laboratory-confirmed SARS-CoV-2 breakthrough infections in fully vaccinated adolescent patients

Researchers investigated whether COVID-19 vaccination effectively protected adolescents in the United States from multisystem inflammatory syndrome (MIS).

2 Jun 2022

The effect of corticosteroids on mortality in hospitalized COVID-19 patients

Researchers assessed the impact of modern causal inference methods in estimating the effect of corticosteroids against COVID-19-related mortality.

2 Jun 2022

Pneumonia frequency and severity found to be lower in patients with full COVID-19 vaccination

According to ARRS' American Journal of Roentgenology (AJR), evaluating chest CT findings offers an additional approach for demonstrating the efficacy of different COVID-19 vaccines in reducing the impact of a COVID-19 diagnosis.

1 Jun 2022

Study assesses the safety of breastfeeding during maternal SARS-CoV-2 infection

Researchers assessed the presence of anti-SARS-CoV-2 antibodies in human breast milk.

26 May 2022

Nanotechnology enhanced DNA-chip for SARS-CoV-2 detection with variant differentiation

Researchers differentiated between SARS-CoV-2 variants using nanotechnology.

26 May 2022

The root causes of long-COVID still a mystery

In a recent article posted to the journal Annals of Internal Medicine, researchers presented baseline outcomes from a longitudinal assessment of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), also known as long-COVID.

25 May 2022

The detection and isolation of bat sarbecoviruses from several locations in Japan

The current paper reports the detection of bat Sarbecoviruses from multiple places in Japan with their characteristics.

19 May 2022

Mice live longer with nasal gene therapy

In a recent study published in the Proceedings of the National Academy of Sciences journal, researchers assessed the efficiency of a novel intranasal and injectable therapy in improving life expectancy.

17 May 2022

Triple vaccination found to confer immune protection against SARS-CoV-2 Omicron BA.2 sublineage

Researchers assessed the immune responses induced by two doses or three doses of the BNT162b2 (BNT) or the CoronaVac (CorV) vaccine against SARS-CoV-2 Omicron BA.2 sublineage among public servants working for the government of Hong Kong.

16 May 2022

Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

Researchers used a novel diagnostic screen, monocyte distribution width for SARS-CoV-2 and influenza infection.

9 May 2022

Asymptomatic SARS-CoV-2 infection among research personnel: Study

A recent research paper published in the journal Public Library of Science (PLOS) ONE analyzed asymptomatic coronavirus disease 2019 (COVID-19) in personnel engaged in academic study.

26 Apr 2022