Rheumatism News and Research

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Rheumatism is a group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat.

Study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis

During pregnancy, women with inflammatory arthritis usually experience disease improvement or even remission, while a disease flare regularly occurs within 3 to 4 months after delivery.

27 Jun 2006

Vitamin K in the U.S. diet

Much of what is known about the content of vitamin K in the US food supply comes from research conducted in the Vitamin K Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

6 Jun 2006

Atorvastatin may increase new blood vessel formation

Systemic sclerosis (SSc), also known as scleroderma, is an uncommon and confounding disease characterized by excessive fibrous tissue formation and vascular abnormalities.

6 Jun 2006

Study shows strong association between treatment with TNF-blocking antibodies and development of serious infections

A new meta-analysis of many previous studies of TNF- (tumor necrosis factor) blocking antibodies for treatment of rheumatoid arthritis has confirmed a previously discovered increased risk for serious infection and has found that cancer also is a potential risk associated with the drugs.

17 May 2006

New discovery about role of sugar in cell communication

A research team from Uppsala University has uncovered an entirely new mechanism for how communication between cells is regulated.

9 May 2006

The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

Drugs aimed at suppressing inflammation-provoking cytokines--specifically those linked to T-cells--have improved the treatment of rheumatoid arthritis (RA), a chronic, inflammatory autoimmune disease. Still, the frequency of remission achieved by these biologic agents remains below 50 percent.

3 May 2006

Cellular events leading to chondrocyte death after cartilage impact injury

Documented in extensive studies, backed by the anecdotal evidence of professional athletes, impact injury to joints causes degeneration of cartilage.

3 May 2006

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Inflammation, cartilage and bone erosions, joint destruction--that's the typical progression of arthritis and most rheumatic diseases.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

Link between rheumatoid arthritis and cancer examined

Rheumatoid arthritis is an inflammatory disease of the immune system and is thought to be linked to an increased risk of cancers of the lymphatic system.

28 Feb 2006

Study associates chronic, severe inflammation with increased lymphoma risk among RA patients

An inflammatory disease of the immune system, rheumatoid arthritis (RA) is associated with increased occurrence of lymphoma--or cancers of the lymphatic system, which plays an integral role in the body's ability to fight infection.

27 Feb 2006

Study associates meniscal damage with advanced cartilage loss in early osteoarthritis

Cartilage loss is a major component of osteoarthritis (OA), a joint disease that affects over 20 million Americans. In knee OA, cartilage loss is influenced by knee injury, as well as obesity and age. Every healthy knee is supported and protected by a pair of meniscus.

27 Feb 2006

Statins show beneficial effect on rheumatoid arthritis

Generation of neoantigenic epitopes after posttranslational modification of Type II collagen by factors present within the inflamed joint

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints, which gradually erodes the cartilage and bone.

7 Dec 2005

Rheumatism News and Research

Further Reading

Study of fetal DNA in serum and disease activity during pregnancy in women with inflammatory arthritis

Vitamin K in the U.S. diet

Atorvastatin may increase new blood vessel formation

Study shows strong association between treatment with TNF-blocking antibodies and development of serious infections

New discovery about role of sugar in cell communication

The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

Cellular events leading to chondrocyte death after cartilage impact injury

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

Targeting the inflamed synovium: The quest for specificity

Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Link between rheumatoid arthritis and cancer examined

Study associates chronic, severe inflammation with increased lymphoma risk among RA patients

Study associates meniscal damage with advanced cartilage loss in early osteoarthritis

Statins show beneficial effect on rheumatoid arthritis

Another use for statins - treating rheumatoid arthritis

Evidence supports combination therapy for achieving remission of early rheumatoid arthritis

New model for the origin of rheumatoid arthritis

New insights into pain mechanisms

Generation of neoantigenic epitopes after posttranslational modification of Type II collagen by factors present within the inflamed joint

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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