Ribonucleic Acid News and Research

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Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Interfering RNA nanoparticles could be a potential COVID-19 therapy

Study shows lipid nanoparticle-based siRNA is potent in suppressing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – in cells as well as in mice models.

21 Apr 2021

SARS-CoV-2 pandemic underscores importance of understanding evolution of RNA genomes

The current COVID-19 (coronavirus disease 2019) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscores the importance of understanding the evolution of ribonucleic acid (RNA) genomes.

21 Apr 2021

Chronic SARS-CoV-2 infections favor viral adaptation, says study

A new study offers a look at how to keep these hopes alive in the current context of highly infectious variants, which often display immune escape mutations.

20 Apr 2021

Limited SARS-CoV-2 spread in childcare centers, finds study

A new study adds to the sum of evidence that children do not play a key role in the transmission of the SARS-CoV-2, the pathogen behind the current pandemic of COVID-19.

20 Apr 2021

Study sheds light on how tau aggregates promote Alzheimer’s disease

Look deep inside the brain of someone with Alzheimer's disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you'll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.

17 Apr 2021

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

Vaccine rollouts all over the world are aimed at cutting short the coronavirus disease 2019 (COVID-19) pandemic by inducing antibody-mediated immunity to the virus. A new study, recently released on the medRxiv* preprint server, addresses the successful reduction in viral spread and case incidence among residents of long-term care facilities (LTCF).

16 Apr 2021

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

A new study, released on the medRxiv* preprint server, examines the presence of SARS-CoV-2-specific IgA in human milk and its association with the protection of breastfed infants against the disease.

16 Apr 2021

Ovarian follicular function unaffected by SARS-CoV-2 infection or Pfizer vaccine, study finds

A new study by researchers in Jerusalem indicates that while specific antibodies to the virus are present in both serum and ovarian follicles following infection or vaccination, there is no apparent adverse effect on follicular function as a result.

15 Apr 2021

High antibody and inflammatory mediator levels may predict severe COVID-19

A new study reports on biomarkers could help predict the progression of the viral illness to dangerous levels early enough to enable timely intervention.

15 Apr 2021

ACE2 homology in laboratory and wild animals

A new preprint research paper posted to the bioRxiv server describes the conservation of an important receptor gene for the virus among several animal species that live in close contact or proximity to humans.

13 Apr 2021

Study finds no evidence of SARS-CoV2 transmission by breast milk

Some studies have reported the detection of SARS-CoV-2 RNA in breast milk from women who were recently infected with the virus. A new study explores the relationship between viral RNA and infectious virus to clarify the occurrence of vertical transmission through breast milk.

9 Apr 2021

Does natural infection with SARS-CoV-2 offer more protection than a vaccine against new variants?

A new study demonstrates that vaccines may be less effective at countering the newer SARS-CoV-2 variants compared to natural infection.

9 Apr 2021

Serum and breast milk SARS-CoV-2 antibodies correlated in vaccinated mothers

A new study shows the correlation between serum levels of antibodies to SARS-CoV-2 and levels in breast milk following the vaccination of lactating women with a vaccine based on mRNA technology.

9 Apr 2021

Microrna-29 molecule controls brain maturation in mammals

A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions.

8 Apr 2021

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

7 Apr 2021

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife.

6 Apr 2021

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

A fascinating new preprint research paper posted to the bioRxiv* server discusses impressively high neutralizing responses elicited with a single dose of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine formulation, which could help turn the tide of the current pandemic if validated.

6 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies

A new research paper published in the Biophysical Journal describes a novel binding pocket used by a viral non-structural protein (nsp) to form an activated complex with its partner nsp. In so doing, it may have revealed a common target that may be useful in the development of a broad-spectrum antiviral drug against all coronaviruses.

1 Apr 2021

Ribonucleic Acid News and Research

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Interfering RNA nanoparticles could be a potential COVID-19 therapy

SARS-CoV-2 pandemic underscores importance of understanding evolution of RNA genomes

Chronic SARS-CoV-2 infections favor viral adaptation, says study

Limited SARS-CoV-2 spread in childcare centers, finds study

Study sheds light on how tau aggregates promote Alzheimer’s disease

Rapid mRNA vaccination effectively controls SARS-CoV-2 transmission in long-term care facilities

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

Ovarian follicular function unaffected by SARS-CoV-2 infection or Pfizer vaccine, study finds

High antibody and inflammatory mediator levels may predict severe COVID-19

ACE2 homology in laboratory and wild animals

Study finds no evidence of SARS-CoV2 transmission by breast milk

Does natural infection with SARS-CoV-2 offer more protection than a vaccine against new variants?

Serum and breast milk SARS-CoV-2 antibodies correlated in vaccinated mothers

Microrna-29 molecule controls brain maturation in mammals

UNC scientists identify a molecule as powerful controller of brain maturation in mammals

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Novel hydrogel-based vaccine formulation shows high efficacy against SARS-CoV-2

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Discovery of cryptic pocket in SARS-CoV-2 may lead to pan-coronavirus therapies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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