Ribosome News and Research

RSS

Researchers unravel how drug interacts with ribosome to halt protein production

The discovery of a chemical compound that halts the production of a small set of proteins while leaving general protein production untouched suggests a new drug search strategy: Find compounds that target undesired proteins before they are even made.

23 Mar 2017

BUSM researchers uncover unique patterns of protein synthesis linked to increased longevity

Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model organisms. Yet, how these different aging genes and pathways are interconnected remains poorly understood.

23 Feb 2017

Scientists identify novel mutations in bacteria that promote evolution of antibiotic resistance

Scientists from the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, have identified novel mutations in bacteria that promote the evolution of high-level antibiotic resistance.

21 Feb 2017

Research provides more evidence that mRNA vaccines can protect mice against Zika virus

Vaccine developers have successfully protected mice against Zika by injecting synthetic messenger RNA that encodes for virus proteins into the animals.

17 Feb 2017

Research shows how cutting calories can slow aging process

There's a multi-billion-dollar industry devoted to products that fight signs of aging, but moisturizers only go skin deep. Aging occurs deeper -- at a cellular level -- and scientists have found that eating less can slow this cellular process.

13 Feb 2017

LMU study shows crucial role of microRNAs in protecting precursors of neurons

Programmed cell death is an integral part of embryonic development. Exploring the regulation of the process, Ludwig-Maximilians-Universitaet in Munich researchers have shown that so-called microRNAs protect the precursors of neurons from 'precocious' elimination.

13 Feb 2017

New Caltech study shows how chaperones protect ribosomal proteins

For proteins, this would be the equivalent of the red-carpet treatment: each protein belonging to the complex machinery of ribosomes -- components of the cell that produce proteins -- has its own chaperone to guide it to the right place at the right time and protect it from harm.

3 Feb 2017

Advanced NMR-based methods for studying RNPs and drug design

Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool widely used in chemical research to investigate the structure and dynamics of molecules.

From Bruker BioSpin - NMR, EPR and Imaging 24 Jan 2017

Mayo Clinic researchers identify genetic promoter that drives lung cancer formation

Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer.

19 Jan 2017

Surveillance machinery in cells recognizes and destroys defective genetic material, research shows

New research out of Case Western Reserve University School of Medicine describes a mechanism by which an essential quality control system in cells identifies and destroys faulty genetic material. The findings were published online December 23 in Nature Communications.

11 Jan 2017

Research finds link between p53 pathway and ribosome biogenesis, nucleotide metabolism in DBA

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer.

17 Dec 2016

Defective ribosomes linked to aggressive form of multiple myeloma

20 to 40 percent of the patients with multiple myeloma - a type of leukaemia - have a defect in the ribosome, the protein factory of the cell.

9 Dec 2016

Scientists discover ribosomal protein-based cancer signature

A research team at the University of Basel's Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature.

6 Dec 2016

Scientists develop safe, highly efficient method to improve searching of new germicides

Scientists from the Lomonosov Moscow State University in cooperation with colleagues have worked out a safe, not that expensive and highly efficient method, which allows to speed up and improve searching of new germicides.

29 Nov 2016

Two widely prescribed antibiotics may combat bacteria differently than previously thought

Two widely prescribed antibiotics -- chloramphenicol and linezolid -- may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found.

2 Nov 2016

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

21 Oct 2016

Scientists find how selenium gets integrated into protein molecules

Humans need eight essential trace elements for good health, and one of them is selenium - a powerful antioxidant that is important for thyroid and brain function as well as metabolism.

6 Oct 2016

Research finds evidence linking number of ribosomal genes to bacterial growth rate and efficiency

Microbes that can reproduce rapidly in times of plenty have an evolutionary stockpile of extra genes that allows them to quickly respond to changing conditions such as oil spills or outbreaks of intestinal diseases.

3 Oct 2016

Researchers discover how cells know when to stop producing mRNA

A new scientific study conducted by a team of leading geneticists has characterized how cells know when to stop translating DNA into proteins, a critical step in maintaining healthy protein levels and cell function.

30 Sep 2016

Scientists identify molecule in liver cells that regulates release of fats into the bloodstream

ETH researchers have discovered a molecule in liver cells that controls the release of fat into the bloodstream. This "lock keeper" is present in large quantities in overweight people and leads indirectly to vascular narrowing.

28 Sep 2016