Secondary Cancer News and Research

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New insights into cancer cell signaling could help prevent metastases

Research published yesterday in Nature Communications has revealed a previously unknown mechanism by which metastasising cancer cells survive when they break away from the primary tumour. It is hoped that the discovery could help with the development of novel cancer treatments that prevent metastasis.

24 Jun 2016

Clinical review examines benefit of RT in breast cancer patients with BRCA1, BRCA2 mutations

In light of conflicting and inconclusive clinical data on the benefit of radiation therapy in cancer patients with the BRCA1 and BRCA2 mutation, a clinical review examined the current status of data regarding BRCA1 and BRCA2 deficiency and radiation therapy sensitivity and a potential strategy to intensify the effects of radiation therapy (RT) by poly(ADP-ribose) polymerase inhibitors (PARPi), the pharmacologic drugs under investigation as monotherapy for the treatment of breast cancer in patients with BRCA1 and BRCA2 mutations.

9 Mar 2016

Researchers analyze how Topo II enzyme may affect stability of genomes

While researchers are now familiar with how cancer begins—cells mutate and then multiply wildly out of control—it is still uncertain exactly how that mutation starts in the molecules of the cells.

22 Feb 2016

ISIBELa joint research project aims to improve cancer therapy

Some individuals experience cancer recurrence when they enter adolescence or adulthood after they have been successfully treated for cancer in childhood while others don't. But why is this? This is the core question being considered in a research project directed by the University Medical Center of Johannes Gutenberg University Mainz.

27 Oct 2015

Radiation/chemotherapy increases risk of leukemia in early-stage breast cancer patients

The risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer remains very small, but it is twice as high as previously reported, according to results of a new study led by researchers at the Johns Hopkins Kimmel Cancer Center.

23 Dec 2014

Experimental drug may help fight cervical cancer

University of Leicester academic leads study into effects of cediranib drug in chemotherapy treatment of cervical cancer.

24 Oct 2014

Cediranib combined with chemotherapy improves survival in recurrent cervical cancer

For patients with cervical cancer that has recurred after treatment or has spread elsewhere in the body, adding the experimental drug cediranib to standard chemotherapy improves tumour shrinkage and adds a modest improvement in progression-free survival, researchers report at the ESMO 2014 Congress in Madrid.

29 Sep 2014

Researchers develop protein therapy that may stop cancer growth

A team of Stanford researchers has developed a protein therapy that disrupts the process that causes cancer cells to break away from original tumor sites, travel through the blood stream and start aggressive new growths elsewhere in the body.

22 Sep 2014

Young adults with secondary thyroid cancer may have greater risk of dying than those with primary cancer

A new analysis has found that adolescents and young adults who develop thyroid cancer as a secondary cancer have a significantly greater risk of dying than those with primary thyroid cancer.

24 Feb 2014

Early stem cell transplants does not improve overall survival in non-Hodgkin's lymphoma patients

Performing early stem cell transplants in patients with aggressive non-Hodgkin's lymphoma does not improve overall survival in high-risk patients, according to a study published in the New England Journal of Medicine.

31 Oct 2013

Research finds no increased risks of mortality for early-stage breast cancer patients receiving XRT

Early-stage breast cancer patients who receive external beam therapy (XRT) are not at higher risk for serious long-term side effects in the chest area, including increase in deaths from cardiac disease and secondary malignancies, according to research presented today at the American Society for Radiation Oncology's 55th Annual Meeting.

25 Sep 2013

Aggressive surveillance questionable for eye melanoma recurrence

Patients treated for primary choroidal or ciliary body melanoma may not always benefit from an aggressive surveillance strategy for the detection of metastatic disease, caution US researchers.

14 Jan 2013

Algorithms designed to find patients with recurrent cancer within databases do not work

In order to study the effectiveness or cost effectiveness of treatments for recurrent cancer, you first have to discover the patients in medical databases who have recurrent cancer. Generally studies do this with billing or treatment codes - certain codes should identify who does and does not have recurrent cancer. A recent study published in the journal Medical Care shows that the commonly used data determinants of recurrent cancer may be misidentifying patients and potentially leading researchers astray.

4 Jan 2013

Annual follow up after ESD for early gastric cancer recommended

Almost all recurrent lesions in gastric epithelial cancer could be cured by endoscopic submucosal resection with annual follow-up exams, say the authors of a Japanese study.

23 Aug 2012

High-risk HPV may increase chances of second malignancy in oral cancer

The proportion of oral squamous cell carcinoma patients infected with the human papillomavirus could be around a third, with high-risk versions of the virus accounting for almost three-quarters of those affected, indicate Taiwanese study results.

12 Jul 2012

Secreted vesicles play role in spread of cancer

Cancer researchers have known for well over a century that different tumor types spread only to specific, preferred organs. But no one has been able to determine the mechanisms of organ specific metastasis, the so-called "soil and seed" theory of 1889. New details that could help shed light on this hypothesis have been provided by a team of researchers from Weill Cornell Medical College, Memorial Sloan-Kettering Cancer Center, and their collaborators, proposing a new mechanism controlling cancer metastasis that offers fresh diagnostic and treatment potential.

29 May 2012

Secondary cancer risk from MDCT scans is low among older adults

The secondary cancer risk from multi-detector computed tomography (MDCT) scans is low among older adults, according to a study from Stanford University in the April issue of the Journal of the American College of Radiology. MDCT is a high-speed imaging technique that is commonly used to diagnose a variety of diseases and conditions.

3 Apr 2012

Papillary renal cell carcinoma patients face low tumour re-occurrence and cancer-related death rates

Patients with papillary renal cell carcinoma, the second most common kidney cancer subtype, face a low risk of tumour recurrence and cancer-related death after surgery. Those are the key findings of a multi-centre study of nearly 600 patients published in the April issue of the urology journal BJUI.

29 Mar 2012

New technique can detect small secondary brain tumours

Cancer Research UK scientists have developed a technique they believe could be used to detect tiny secondary tumours in the brain, a process that is currently impossible, according to research published in PNAS.

27 Mar 2012

NYU Cancer Institute scientists present new research findings at ASCO 2011

Experts from The Cancer Institute, an NCI-designated cancer center, at NYU Langone Medical Center presented new research findings at the 47th American Society of Clinical Oncology (ASCO) 2011 Annual Meeting in Chicago, IL.

8 Jun 2011