Septic Shock News and Research

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Capillary leakage important in COVID-19 respiratory distress

Now, a new study published on the preprint server medRxiv reports the pivotal role played by protein leakage through lung capillaries and promotes the use of serum albumin as a biomarker of disease progression and severity.

24 May 2020

Teens develop septic shock due to COVID-19

Since the emergence of the novel coronavirus disease (COVID-19), most people who develop severe illness are older adults, those with underlying medical conditions, and those who are immunocompromised. Though children are mostly spared, some adolescents developed septic shock due to COVID-19, a new study has found.

24 May 2020

Blanket prescription of do-not-resuscitate orders in COVID-19 patients may be unwarranted

It's inappropriate to consider blanket do-not-resuscitate orders for COVID-19 patients because adequate data is not yet available on U.S. survival rates for in-hospital resuscitation of COVID-19 patients and data from China may not relate to U.S. patients, according to a new article published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

22 May 2020

Researchers investigate safety of convalescent plasma for COVID-19

The current pandemic of COVID-19 seems to be slowing down in various parts of the world, but is far from controlled, as incidence rates rise in new regions. In the absence of an effective vaccine or therapeutic drug, scientists have relied on supportive medical care to treat the sick.

17 May 2020

High DPP3 concentration in the blood predicts multiple organ failure in burn patients

Diagnostics company SphingoTec GmbH ("sphingotec") and 4TEEN4 Pharmaceuticals GmbH ("4TEEN4") announced today the publication of new data showing that high blood levels of Dipeptidyl Peptidase 3 (DPP3) are indicating upcoming multiple organ failure and mortality risk in burn patients.

15 May 2020

How toxic are chloroquine and hydroxychloroquine to cells?

The spread of the pandemic disease COVID-19 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has now reached almost every country of the world, with over 3.11 million cases and over 217,000 deaths as of April 29, 2020.

29 Apr 2020

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Overreaction is rarely useful, and in the case of the human immune system, it can be outright deadly. When the body overreacts to an infection, the result is sepsis - a life-threatening condition that frequently leads to acute organ dysfunction, including deterioration of the heart and blood vessels, which make up the cardiovascular system.

24 Apr 2020

RAS inhibitors and COVID-19 severity in hypertensive patients

A new study published in the journal JAMA Cardiology in April 2020 reports that patients with hypertension who are taking medications called ACE inhibitors (ACEI) or ARBs are not at higher risk for death or more severe illness with COVID-19. This conclusion supports current guidelines for the treatment of hypertension during this pandemic.

23 Apr 2020

Hyperferritinemia associated with increased illness severity in COVID-19

Yehuda Shoenfeld is the world's leading expert in the research, treatment and prevention of autoimmune diseases.

22 Apr 2020

Scientists estimate fatality ratio across full spectrum of COVID-19 disease

A team of researchers from Imperial College London has conducted a study aimed at calculating a reasonably accurate case fatality ratio and infection fatality ratio, which is based on Chinese data as well as international reports. The research is published on the pre-print server MedRxiv.

19 Apr 2020

Research findings could aid in the recognition and management of COVID-19 pneumonia

Researchers have identified the most common clinical characteristics of 109 patients with COVID-19 related pneumonia who died in Wuhan, China in the early stages of the coronavirus pandemic, according to a new study published online in the Annals of the American Thoracic Society.

7 Apr 2020

Has COVID-19 affected diabetes care?

The COVID-19 pandemic is rampaging across continents, leaving death, fear, and uncertainty in its wake. The virus is known to cause more severe illness and have a higher death rate in people who are already sick or immunocompromised, as well as the elderly. Several nations, states, and provinces have announced total lockdowns to try and minimize the impact of the virus.

29 Mar 2020

Sphingotec’s bio-ADM can reliably support physicians in identifying high-risk sepsis patients

Diagnostics company SphingoTec GmbH today reported on new data on the utility of endothelial function biomarker bioactive Adrenomedullin

5 Mar 2020

New set of recommendations for managing liver failure in the ICU

For critical care specialists, hepatic failure poses complex challenges unlike those of other critical illnesses.

16 Feb 2020

Immune cells count each other in order to decide whether to attack

A new study published in the journal Nature Communications in February 2020 shows that immune cells consult and coordinate with each other at the site of activity to bring about a balanced but adequate reaction and stave off the threat.

13 Feb 2020

Macrophages consult with neighbors before making decisions

Many people consult their friends and neighbors before making a big decision. It turns out that cells also are consulting their neighbors in the human body.

13 Feb 2020

Study tests hypothesis that empty SV40 capsids would improve sepsis outcomes

Numerous previous attempts to develop therapeutic treatments, directed at discreet targets of the sepsis cascade, could not cope with the complex pathophysiology of sepsis and failed.

13 Feb 2020

Coronavirus could spread explosively, tight control needed

The coronavirus may be taking a higher toll of life than we thought, say scientists, in a new study published on January 30, 2020, in The Lancet. But another startling new study based on mathematical modeling, published in the same journal, predicts that almost 76,000 people may have acquired the infection in Wuhan city, and that multiple epidemics in major connected cities inside and outside China may already be brewing. Yet the death rate is markedly low, in this case.

3 Feb 2020

Vitamin C-B1-steroid combo associated with lower mortality in children with septic shock

Treating septic shock in children with a combination of intravenous vitamin C, vitamin B1 and hydrocortisone (a commonly used steroid) is associated with lower mortality, according to a study from Ann & Robert H. Lurie Children's Hospital of Chicago.

21 Jan 2020

Vitamin C and thiamine plus steroids do not improve septic shock outcome finds study

A randomized clinical trial showed that combining Vitamin C and thiamine with standard steroid hydrocortisone did not improve the time of survival for patients with septic shock. The study titled, “Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial,” was published in the most recent issue of JAMA.

19 Jan 2020