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‘Like a ghost town’: Erratic nursing home staffing revealed through new records

Most nursing homes had fewer nurses and caretaking staff than they had reported to the government, according to new federal data, bolstering the long-held suspicions of many families that staffing levels were often inadequate.

13 Jul 2018

Scoring system based on PIRO helps predict mortality in surgical ICU patients with severe sepsis

A new classification system that scores the variables associated with mortality rates for patients who develop intra-abdominal sepsis after surgery may help guide care and improve outcomes

2 Jul 2018

Study reveals new way to inhibit capillary leakage in sepsis

Leakage from the blood capillaries is a key mechanism leading to septic shock and multiorgan failure, which affect millions of patients annually worldwide. However, there is no effective way to inhibit the vessel leakiness. A new study by scientists at the University of Helsinki and Wihuri Research Institute demonstrates that vascular leakage can be inhibited by targeting vascular integrins.

25 Jun 2018

Merck announces FDA acceptance of supplemental Biologics License Application for KEYTRUDA

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for standard review a new supplemental Biologics License Application for KEYTRUDA, Merck's anti-PD-1 therapy, as adjuvant therapy in the treatment of patients with resected, high-risk stage III melanoma and granted a Prescription Drug User Fee Act, or target action, date of February 16, 2019.

25 Jun 2018

Delayed lactate measurements in sepsis patients increase risk of in-hospital death

The rising incidence of sepsis, a leading cause of in-hospital death, has prompted the Centers for Medicare and Medicaid Services to issue protocols known as care bundles to standardize and improve sepsis care.

25 May 2018

Updated SSC Bundle aims to improve survival for sepsis patients

For patients with sepsis, a serious infection causing widespread inflammation, immediate treatment is essential to improve the chances of survival. An updated "Hour-1 Bundle" of the international, evidence-based guidelines for treatment of sepsis is introduced in the June issue of Critical Care Medicine.

18 May 2018

New class of antimicrobial polymers can kill five hard-to-treat multidrug-resistant bacteria

An international research team led by the Institute of Bioengineering and Nanotechnology of the Agency for Science, Technology and Research and IBM Research developed a synthetic molecule that can kill five deadly types of multidrug-resistant bacteria with limited, if any, side effects.

7 Mar 2018

Platelets play more important role in the immune system than previously thought

Platelets play a much more important role in our immune system than previously thought, according to a study published by researchers from Université Laval and Centre hospitalier universitaire de Québec Research Center.

1 Feb 2018

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Disorders caused by a leaky vasculature are more common than most people think. Despite ICU treatment, one third of the 27 million patients globally that suffer from sepsis, and up to 20% of the more than 5 million US patients with congestive heart failure die every year from their condition.

5 Jan 2018

Macrophage nanosponges offer promising solution for effectively managing sepsis

A team of researchers at the University of California San Diego has developed macrophage "nanosponges" that can safely absorb and remove molecules from the bloodstream that are known to trigger sepsis.

4 Jan 2018

Review calls for improvement in post-hospital recovery care for sepsis survivors

Despite improvement in the rates of people dying of sepsis in the hospital, the condition is still a leading cause of hospital readmissions and costs, as well as long-term disabilities and impairments, prompting University of Pittsburgh and University of Michigan medical scientists to develop thorough recommendations for post-hospital recovery care and future clinical trials.

2 Jan 2018

Multiple sclerosis drug can beat obstinate bacteria

Encountering bacteria with innocent names such as Pseudomonas aeruginosa and Enterobacteriaceae can lead to hospitalization and - in a worst-case scenario - can also be life-threatening. The bacteria, which cause infections such as pneumonia, frequently develop multi-resistance towards classic antibiotics.

22 Nov 2017

Electronic alert system helps clinicians to quickly identify children with severe sepsis in ER

An electronic alert system helps clinicians quickly do a bedside assessment to identify children with severe sepsis in an emergency department. Researchers from Children's Hospital of Philadelphia report on their efforts to rapidly recognize this life-threatening condition.

13 Sep 2017

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Firstly, it is necessary to make a distinction between systemic inflammation and Systemic Inflammatory Response Syndrome (SIRS). SIRS consists of changes in clinical signs including an abnormal body temperature, increased heart rate, increased respiratory rate, an abnormal white cell count (either decreased or elevated), or an increase in band neutrophils.

7 Sep 2017

Intensive Care Medicine

Intensive care medicine is a young specialty that deals with the medical treatment of the sickest patients in the hospital. Intensive care medicine doctors are called intensivists and are expert physicians with special skills in the management of organ failure.

29 Aug 2017

Research shows probiotics can reduce incidence of sepsis in infants

A research team at the University of Nebraska Medical Center College of Public Health has determined that a special mixture of good bacteria in the body reduced the incidence of sepsis in infants in India by 40 percent at a cost of only $1 per infant.

16 Aug 2017

Opioid crisis results in increased admissions to hospital ICUs and deaths

The opioid crisis in the United States is resulting in increased admissions to hospital intensive care units and in increased numbers of ICU deaths from opioid overdoses, according to new research published online, ahead of print in the Annals of the American Thoracic Society.

11 Aug 2017