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The importance of the endosomal pathway for SARS-CoV-2 entry

Researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked SARS-CoV-2 entry into mammalian cells.

21 Mar 2022

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Researchers assessed the impact of recombinant accessory protein-deficient severe acute respiratory syndrome coronavirus 2 immunization against SARS-CoV-2 transmission and disease severity.

18 Mar 2022

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Researchers explored neuroinflammation and COVID-19-induced ischemic stroke recovery.

17 Mar 2022

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Researchers evaluate the feasibility of tonsil epithelial cell-derived organoids as an ex vivo model for studying SARS-CoV-2 infection.

15 Mar 2022

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Amino acids are the basic building blocks of living organisms and typically occur in a configuration known as the L-form. However, there are a few exceptional examples of the structural mirror image of the L-form (known as the D-form) being present in animals.

11 Mar 2022

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Researchers screened 5,000 Food and Drug Association-approved drugs to identify repurposed drugs targeting SARS-CoV-2 spike protein cleavage at both S1/S2 boundary and S2’.

11 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

In a recent study posted to the bioRxiv* preprint server, researchers presented the intragenomic rearrangements of β-coronaviruses (CoVs), including severe acute respiratory syndrome CoV 2 (SARS-CoV-2).

9 Mar 2022

How will mutations change the SARS-CoV-2 spike protein in the future?

A new Cells review discusses the factors that affect the function of the SARS-CoV-2 S protein and provides theoretical limits of this viral protein.

8 Mar 2022

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

A new study discusses the outcomes of idiopathic pulmonary fibrosis patients with confirmed SARS-CoV-2 infection.

6 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

Dual therapeutic potential of zapnometinib against COVID-19

Researchers assessed the impact of the drug zapnometinib on human immune response against coronavirus disease 2019.

2 Mar 2022

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced positive top-line results from the Phase 2 part of the Phase 2/3 study of once-daily oral RHB-107 (upamostat) in non-hospitalized symptomatic COVID-19 patients, predominantly conducted in the U.S. (60/61 patients) as well as South Africa.

1 Mar 2022

Serine News and Research

The importance of the endosomal pathway for SARS-CoV-2 entry

Study evaluates COVID-19 vaccination with recombinant accessory protein-deficient SARS-CoV-2

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

In silico screening and testing of FDA approved drugs inhibiting SARS-CoV-2 spike protein cleavage

Novel genetic relationships with severe SARS-CoV-2

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Intragenomic rearrangements help explain how SARS-CoV-2 variants arise

How will mutations change the SARS-CoV-2 spike protein in the future?

How does COVID-19 affect patients with idiopathic pulmonary fibrosis?

Combating COVID cytokine storm with targeted nucleic acid therapies

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

Dual therapeutic potential of zapnometinib against COVID-19

Phase 2/3 study of oral RHB-107 in non-hospitalized COVID-19 patients shows promising results

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Histopathologic and molecular effects in the placenta after SARS-CoV-2 infection during pregnancy

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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