Severe Acute Respiratory News and Research

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Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

New study results highlight that Omicron has an increased affinity to ACE-2 receptors, therefore, has increased infectivity, viral load, and transmissibility compared to other variants of concern, including the Delta variant.

22 Dec 2021

Extended interval between second and third vaccination beneficial against SARS-CoV-2 Omicron variant

A new study proposes a multi-boost vaccine strategy with a longer duration between the second and third dose, as that would be beneficial in acquiring immunity against severely mutated SARS-CoV-2 variants.

22 Dec 2021

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

A new study shows that the optimization of nitazoxanide formulations may allow the review of the potential use of the drug for the treatment of SARS-CoV-2 infection.

22 Dec 2021

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

A team of scientists from Canada has recently characterized a panel of nanobodies against the spike protein of SARS-CoV-2.

22 Dec 2021

Defensosomes can act as decoys to protect against SARS-CoV-2

In a new study, researchers from New York University have been examining the ability of defensosomes to combat SARS-CoV-2 infection.

22 Dec 2021

Furin cleavage site similarities in SARS-CoV-2 and rodent coronavirus indicate common wildlife host

New study findings show that AcCoV-JC34 is the only luchacovirus containing a –RR-R- motif that is identical to the one found in SARS-CoV-2.

22 Dec 2021

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

A study found that the Mediterranean diet, when combined with non-smoking and regular physical activity, can lower susceptibility to SARS-CoV-2.

22 Dec 2021

Importance of pneumococcal vaccination during the COVID-19 pandemic

A new study discusses the necessity and role of pneumococcal immunization in strengthening the global health system amid the current COVID-19 pandemic.

22 Dec 2021

Two-dose ChAdOx1 vaccine protection wanes after three months

New research reported in the journal The Lancet examines the temporal association between the two-dose ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccination regimen and the risk of severe outcomes from COVID-19 in Scotland vs. Brazil, where the Delta variant of SARS-CoV-2 was dominant and rare, respectively.

21 Dec 2021

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

A new preprint research paper posted to the bioRxiv* server examines the nature and effects of the spike mutations and identifies a vulnerable point that could help develop broad-spectrum protection against circulating variants.

21 Dec 2021

National U.S trial confirms effectiveness of mRNA COVID-19 vaccines

In a recent study, published in the Annals of Internal Medicine, scientists conducted a target trial emulation study and documented that among the elderly in the U.S. (with significant comorbidities), the efficacy of messenger RNA (mRNA) vaccines was much lower in terms of preventing infection, than previously reported. However, the effectiveness against death was found to be high.

21 Dec 2021

Comparison of SARS-CoV-2 rapid antigen tests

Researchers test commercially rapid antigen tests to evaluate their analytical sensitivity and specificity, as well as clinical sensitivity for detecting SARS-CoV-2.

21 Dec 2021

Risk of exposure to SARS-CoV-2 by workplace and trade

Researchers investigate the risk of SARS-CoV-2 exposure to people in workplaces across different occupations over time.

21 Dec 2021

How the SARS-CoV-2 Omicron variant spike protein is changing

The study assesses the degree to which the D614G mutation in the SARS-CoV-2 RBD allows access of spike protein trimers to LA-binding-like conformations.

21 Dec 2021

Comparison of point-of-care SARS-CoV-2 diagnostic kits

A multinational group of scientists investigates the performance characteristics of several point-of-care diagnostic kits for SARS-CoV-2.

21 Dec 2021

What are the long-term effects of COVID-19 on mental health?

Researchers determine the long-term adverse mental health symptoms associated with COVID-19 by estimating acute infection severity.

21 Dec 2021

Molecular mechanism of SARS-Cov-2-induced thrombosis

Researchers demonstrate that the exposure of platelets to the SARS-CoV-2 spike protein promotes their activation and adhesion.

21 Dec 2021

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Researchers determined IgG titers of vaccinated healthcare workers 11 months following primary COVID-19 vaccination.

21 Dec 2021

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

A new study demonstrates significantly altered structure and cellularity of Peyer’s patches in deceased COVID-19 patients.

21 Dec 2021

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

A new study aimed to detect the genomic material of SARS-CoV-2 and its variants, such as the recently emerged variant of concern (VOC) Omicron.

21 Dec 2021

Severe Acute Respiratory News and Research

Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

Extended interval between second and third vaccination beneficial against SARS-CoV-2 Omicron variant

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

Defensosomes can act as decoys to protect against SARS-CoV-2

Furin cleavage site similarities in SARS-CoV-2 and rodent coronavirus indicate common wildlife host

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

Importance of pneumococcal vaccination during the COVID-19 pandemic

Two-dose ChAdOx1 vaccine protection wanes after three months

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

National U.S trial confirms effectiveness of mRNA COVID-19 vaccines

Comparison of SARS-CoV-2 rapid antigen tests

Risk of exposure to SARS-CoV-2 by workplace and trade

How the SARS-CoV-2 Omicron variant spike protein is changing

Comparison of point-of-care SARS-CoV-2 diagnostic kits

What are the long-term effects of COVID-19 on mental health?

Molecular mechanism of SARS-Cov-2-induced thrombosis

Booster doses offer broader protection in SARS-CoV-2 infected and vaccinated individuals

Severe COVID-19 found to be associated with disrupted intestinal Peyer’s patches

Diagnostic assays that use the 2019-nCoV-N1 primer-probe are unlikely to be impacted by Omicron variant

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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