Severe Acute Respiratory News and Research

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COVID-19 spread in cities driven by socioeconomically weaker groups, study finds

Researchers in Sweden have conducted a study showing that the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within cities is driven by socioeconomically weaker and high-mobility groups. They used Basel, Switzerland as their case study.

21 Dec 2020

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

As the coronavirus disease 2019 (COVID-19) pandemic continues to intensify in many parts of the world, vaccine development is proceeding apace.

21 Dec 2020

SARS-CoV-2 RNA in serum associated with poor prognosis and high mortality

A new preprint indicates the direct correlation between the presence of detectable viral RNA loads in serum, and clinical severity and death.

21 Dec 2020

Cross-reactive coronavirus antibodies shape COVID-19 convalescent plasma functionality

The onset of the current COVID-19 pandemic revealed the seventh known pathogenic human coronavirus, SARS-CoV-2.

21 Dec 2020

South Korean city shows SARS-CoV-2 clade shift from V to GH over time

A new paper from South Korea describes the evolving SARS-CoV-2 genome in a single city, that of Gwangju, in the southwestern region of this country.

21 Dec 2020

Detecting SARS-CoV-2 sequences in blood monocytes

A meeting with doctors from Wuhan presented a compelling observation to Professor Laura Manuelidis, MD, from the Yale Medical School early in 2020.

21 Dec 2020

FDA issues first emergency use authorization for second COVID-19 vaccine

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the second vaccine for the prevention of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

21 Dec 2020

Quantifying SARS-CoV-2 transmission in large urban areas

A team of international researchers used mobility information and socio-demographic data to build a model of SARS-CoV-2 transmission to understand where, when, and how many transmission events occurred in the first wave of the pandemic in the United States.

18 Dec 2020

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Researchers at the Ministry of Health and Social Protection in Bogotá, Colombia, provided evidence of socioeconomic inequalities in COVID-19 deaths in terms of age, sex, ethnicity, type of health insurance regime, and socioeconomic status.

18 Dec 2020

Very few COVID-19-positive children require hospitalization, finds case study

A team of researchers at the Divisions of Infectious Diseases, UPMC Children’s Hospital of Pittsburgh and the University of Pittsburgh, USA, sought to characterize the clinical presentation of children with COVID-19 in Western Pennsylvania.

18 Dec 2020

Remdesivir inhibits SARS-CoV-2 replication by preventing RdRp-mediated RNA translocation

A new study describes the in vitro mechanism by which remdesivir kinetically inhibits the replication of the virus that causes COVID-19, SARS-CoV-2.

18 Dec 2020

Can online health forums track the effect of COVID-19 on mental health?

A team of researchers at King's College London, UK, and other institutions used publicly accessible sources of real-world data, such as online health forums. They found that authors of COVID-19 related posts most frequently mentioned mental health symptom keywords during the first wave, followed by physical symptoms and intensive care keywords.

18 Dec 2020

Rapid no-frills detection of SARS-CoV-2 in saliva with LAMP-Cas13

A new paper that appeared as a preprint on the medRxiv* server in December 2020 describes a nucleic acid test validated on saliva samples.

18 Dec 2020

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

A new paper describes the development and validation of a rapid test to measure the neutralizing activity of serum against COVID-19 using a drop of blood.

18 Dec 2020

Study recommends blinded crossover and continued follow-ups to evaluate SARS-CoV-2 vaccine durability

A new multicenter study has shown that blinded crossover and continued follow-up of trial participants can help assess vaccine durability and potential delayed enhancement of disease.

18 Dec 2020

Experts to share the lessons learnt from COVID-19 first wave

The Physiological Society and the Intensive Care Society have come together to host an exciting three-day virtual conference this week, which will review the challenges of understanding the pathophysiological changes occurring throughout the body following COVID-19 infection.

18 Dec 2020

Continued vigilance is required in England following exit from second lockdown

Researchers in the UK have presented data from the latest in a series of community surveys assessing the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in England.

17 Dec 2020

New prognostic tool predicts the need for ICU among COVID-19 patients

Researchers in the UK have developed a prognostic tool that accurately predicts whether patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent causes coronavirus disease 2019 (COVID-19) – will require admission to the intensive care unit (ICU), die, or survive without escalation to ICU.

17 Dec 2020

How does the UK’s COVID-19 response compare to others in Europe?

Researchers modeled the health benefits and economic loss caused by coronavirus disease 2019 (COVID-19) in the UK and compared them to four other western European countries. Their results suggest the British Government’s response may outweigh the economic loss incurred.

17 Dec 2020

High presence of SARS-CoV-2 nucleic acid in PCR test can predict future symptomatic disease

A new study by researchers at the Karolinska University Hospital in Sweden shows that testing for the presence of SARS-CoV-2 nucleic acid can help in containing the virus spread. Detecting the presence of high amounts of SARS-CoV-2 nucleic acid predicts future symptomatic disease, they found.

17 Dec 2020

Severe Acute Respiratory News and Research

COVID-19 spread in cities driven by socioeconomically weaker groups, study finds

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

SARS-CoV-2 RNA in serum associated with poor prognosis and high mortality

Cross-reactive coronavirus antibodies shape COVID-19 convalescent plasma functionality

South Korean city shows SARS-CoV-2 clade shift from V to GH over time

Detecting SARS-CoV-2 sequences in blood monocytes

FDA issues first emergency use authorization for second COVID-19 vaccine

Quantifying SARS-CoV-2 transmission in large urban areas

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Very few COVID-19-positive children require hospitalization, finds case study

Remdesivir inhibits SARS-CoV-2 replication by preventing RdRp-mediated RNA translocation

Can online health forums track the effect of COVID-19 on mental health?

Rapid no-frills detection of SARS-CoV-2 in saliva with LAMP-Cas13

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

Study recommends blinded crossover and continued follow-ups to evaluate SARS-CoV-2 vaccine durability

Experts to share the lessons learnt from COVID-19 first wave

Continued vigilance is required in England following exit from second lockdown

New prognostic tool predicts the need for ICU among COVID-19 patients

How does the UK’s COVID-19 response compare to others in Europe?

High presence of SARS-CoV-2 nucleic acid in PCR test can predict future symptomatic disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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