Severe Acute Respiratory News and Research

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Study finds high levels of enteric pathogens in children from Alabama's rural areas, highlights sanitation issues

The study reveals a significant presence of enteric pathogens in children from Alabama's Black Belt region, linking well water consumption to increased pathogen detection and underscoring the need for improved sanitation infrastructure.

19 Nov 2023

Pigeon virus causes fatal neurological disease in young leukemia patient

A case report details a fatal neurologic disease in an immunocompromised toddler caused by pigeon avian paramyxovirus, underscoring the effectiveness of metagenomic testing in diagnosing complex infectious diseases.

19 Nov 2023

Lasting heart concerns in kids post-MIS-C: Study urges ongoing cardiac checks

Researchers evaluated the long-term cardiovascular effects in children after treatment for MIS-C, a condition linked to COVID-19. They found that regardless of initial heart injury, most children displayed persistent cardiac abnormalities, underscoring the importance of ongoing cardiac monitoring post-recovery.

16 Nov 2023

Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy

Study discovers that coffee, especially its bioactive compounds like chlorogenic acids, can inhibit SARS-CoV-2 entry and reduce ACE2 and TMPRSS2 levels, indicating that coffee intake might be a potential dietary strategy for COVID-19 prevention.

16 Nov 2023

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

Review examines nirmatrelvir and bisphosphonates in treating COVID-19, revealing their impact on SARS-CoV-2-specific adaptive immunity and potential to mitigate severe infections, highlighting the need for balanced long-term immunity management.

16 Nov 2023

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

The frequency of viral rebound (VR) among acute coronavirus disease 2019 patients.

16 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

Placental inflammation's role in adult depression and heart disease

An expression signature related to inflammation expressed in Hofbauer cells in the placenta, calculating polygenic risk scores to predict its expression.

14 Nov 2023

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

The study in JAMA Network Open evaluates the effectiveness of simultaneously administering the Pfizer-BioNTech BNT162b2 BA.4/5 COVID-19 vaccine and seasonal influenza vaccines versus separate administration. Results suggest similar or slightly increased COVID-19 outcomes and lower influenza-related outcomes with coadministration, particularly in those aged 65 and above.

13 Nov 2023

Hospital-acquired COVID-19 mortality drops in Omicron era post-vaccination, reveals Swedish study

In a study published in JAMA Network Open, researchers found that hospital-acquired SARS-CoV-2 infections in Stockholm led to increased 30-day mortality in the pre-vaccination period but showed significantly lower mortality during the Omicron wave post-vaccination. The study underscores the importance of vaccination in reducing mortality risks from nosocomial SARS-CoV-2 infections.

13 Nov 2023

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

In a JAMA Network Open study, researchers found no evidence of neuroinflammation or blood-brain barrier dysfunction in cerebrospinal fluid markers of individuals with post-COVID-19 condition and neuropsychiatric symptoms compared to controls. The study, which assessed cytokines, chemokines, and neuroinflammation markers, suggests that persistent central nervous system immune activation may not be the primary driver of neurological long COVID symptoms.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Pediatric viral threats surge in the 21st century: A call for One Health approach

Scoping review in "Pediatric Research" examines the rise of pediatric viral diseases in the 21st century and underscores the importance of a One Health approach, integrating human, animal, and ecosystem health, to combat these emerging and re-emerging infectious threats effectively.

9 Nov 2023

Allergies linked to heightened risk of long COVID, new review suggests

Systematic review indicates that pre-existing allergic conditions like asthma and allergic rhinitis may be linked to an increased risk of developing long COVID. Despite some evidence, the certainty remains low due to potential biases and confounding factors, highlighting the need for more rigorous research to determine the impact of these allergies on prolonged COVID-19 symptoms.

9 Nov 2023

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019. Since then, extensive efforts have been made to develop and evaluate vaccines to combat the virus.

8 Nov 2023

Personal biases warp COVID-19 memories, posing a challenge for future pandemic policies

In a series of studies, researchers found that personal biases significantly influence how individuals remember the COVID-19 pandemic, which could potentially shape historical narratives and impact future pandemic policies. They suggest that recognizing these biases is crucial for developing long-term strategies that maintain societal trust and cohesion.

7 Nov 2023

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

The study in Nature Microbiology reviews the concept of immune imprinting and its influence on antibody responses to SARS-CoV-2, highlighting challenges for COVID-19 booster vaccination efficacy against emerging variants. Researchers suggest that understanding immune imprinting is crucial for developing vaccines that elicit broad and lasting immune protection.

7 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

A two-year longitudinal study highlights proteomic changes in long-COVID patients, revealing potential biomarkers for diagnosis and shedding light on the persistent physiological challenges faced by survivors.

7 Nov 2023

Severe Acute Respiratory News and Research

Study finds high levels of enteric pathogens in children from Alabama's rural areas, highlights sanitation issues

Pigeon virus causes fatal neurological disease in young leukemia patient

Lasting heart concerns in kids post-MIS-C: Study urges ongoing cardiac checks

Coffee and COVID: Study finds coffee inhibits SARS-CoV-2, offers new dietary defense strategy

Exploring the dual role of nirmatrelvir and bisphosphonates in COVID-19 treatment and immunity

One in five patients on Nirmatrelvir–Ritonavir experience virologic rebound, new observational study reveals

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Placental inflammation's role in adult depression and heart disease

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

Hospital-acquired COVID-19 mortality drops in Omicron era post-vaccination, reveals Swedish study

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Pediatric viral threats surge in the 21st century: A call for One Health approach

Allergies linked to heightened risk of long COVID, new review suggests

Study compares the immunogenicity and safety of two SARS-CoV-2 vaccines

Personal biases warp COVID-19 memories, posing a challenge for future pandemic policies

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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