Signaling Pathway News and Research

RSS

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Drug combo safely decreases pancreatic cancer growth in mice

A new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel, a new study finds.

9 Oct 2023

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

In a study published in the journal Genes & Diseases, researchers from Army Medical University and Shenzhen University investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis.

9 Oct 2023

EMC1 protein found to play pivotal role in retinal vascular development

In a groundbreaking study published in the journal Genes & Diseases, researchers from University of Electronic Science and Technology of China have uncovered a key relationship between the EMC1 protein and retinal vascular development.

9 Oct 2023

Study sheds light on PRMT1's role in gastric cancer progression

In a study published in the journal Genes & Diseases, researchers from Southwest University, and Southwest Medical University investigated PRMT1, a protein previously known to be overexpressed in gastric cancer cells.

9 Oct 2023

Effectiveness of Lactobacillus in treating inflammatory bowel disease

The role of Lactobacillus in treating inflammatory bowel disease.

4 Oct 2023

Study reveals link between CHD8 gene, gut abnormalities, and autism-related behaviors

The connection between the CHD gene and autism-related gastrointestinal (GI) manifestations.

4 Oct 2023

Could plant-based phytonutrients be the secret weapon against obesity?

This comprehensive review in the journal Foods explores the therapeutic potential of phytonutrients in combating obesity. The paper delves into various plant-based compounds like polyphenols, alkaloids, and terpenoids, detailing their mechanisms of action in inhibiting fat accumulation, regulating metabolism, and even altering gut microbiota.

1 Oct 2023

Study reveals new insights into how the immune system prevents autoimmunity

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body's own, healthy tissues.

29 Sep 2023

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Patients with multiple myeloma, a blood cancer of plasma cells in the bone marrow, who also have diabetes have a reduced overall survival when compared to those without diabetes.

29 Sep 2023

Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.

27 Sep 2023

Study identifies four novel receptors potentially linking endometrial cancer with PCOS

A new research paper was published in Oncotarget's Volume 14 on September 22, 2023, entitled, "Transcriptomic analysis identifies four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome and generates a transcriptomic atlas."

25 Sep 2023

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Researchers explore the role of the CaMKK2 signaling pathway in bipolar disorder, suggesting it as a new treatment target. By targeting this enzyme, scientists aim to develop more effective therapies for bipolar symptoms and metabolic dysfunction.

24 Sep 2023

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.

20 Sep 2023

HNP-1 may be a promising therapeutic agent for hypertensive left ventricular hypertrophy

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Human neutrophil peptide-1 (HNP-1) is a commonly investigated therapeutic agent.

14 Sep 2023

Study sheds new light on the role of 'TonEBP' protein in lupus and lupus nephritis

A groundbreaking discovery has been made by Professor Hyug Moo Kwon and his research team in the Department of Biological Sciences at UNIST, in collaboration with Professor Jaeseok Yang from Yonsei University.

13 Sep 2023

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

An international team of researchers has demonstrated that a combination of inhibitors may suppress tumor growth and prevent relapse in patients with certain cancers, including head and neck squamous cell carcinoma and lung adenocarcinoma.

12 Sep 2023

Arf1 inhibition induces tumor regression by promoting T cell infiltration

In recent years, cancer immunotherapies, represented by immune checkpoint blockade (ICB), have been highly successful and have become an important basis for the future treatment of cancers.

12 Sep 2023

Human post-implantation embryo models show promise in unraveling early development

Researchers evaluate post-implantation development in humans using embryo-like models based on genetically unmodified human naïve embryonic stem cells.

12 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

Signaling Pathway News and Research

Discovery of a novel therapeutic target for pancreatic cancer

Drug combo safely decreases pancreatic cancer growth in mice

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

EMC1 protein found to play pivotal role in retinal vascular development

Study sheds light on PRMT1's role in gastric cancer progression

Effectiveness of Lactobacillus in treating inflammatory bowel disease

Study reveals link between CHD8 gene, gut abnormalities, and autism-related behaviors

Could plant-based phytonutrients be the secret weapon against obesity?

Study reveals new insights into how the immune system prevents autoimmunity

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Blocking Notch signaling pathway could reverse age-related bone loss

Study identifies four novel receptors potentially linking endometrial cancer with PCOS

Could CaMKK2 enzyme be the key to treating bipolar disorder?

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

HNP-1 may be a promising therapeutic agent for hypertensive left ventricular hypertrophy

Study sheds new light on the role of 'TonEBP' protein in lupus and lupus nephritis

A combination of inhibitors may suppress tumor growth and prevent cancer relapse

Arf1 inhibition induces tumor regression by promoting T cell infiltration

Human post-implantation embryo models show promise in unraveling early development

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

Latest News