Signaling Pathway News and Research

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Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

A new study led by University of Cincinnati researchers sheds new light on the role of a signaling pathway in the brain to maintain health and prevent inflammation and cognitive deficits.

24 Jun 2024

ALS: Newly discovered subtypes and sex differences create new approaches for drugs

Amyotrophic lateral sclerosis, ALS for short, is a mysterious neurodegenerative disease that is almost always fatal.

21 Jun 2024

New insights into signaling pathways and resistance mechanisms in colorectal cancer

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The complexity of its pathogenesis, involving genetic mutations, dysregulated signaling pathways, and compromised immune surveillance, presents significant challenges for effective treatment.

21 Jun 2024

Proteins in blood may help to predict Parkinson’s disease up to seven years before the onset of motor symptoms

Researchers combined mass spectrometry-based proteomic phenotyping with machine learning to identify blood biomarkers in early Parkinson's disease.

20 Jun 2024

Study reveals cognitive benefits of ketogenic diet in aged mice

The impact of cyclic ketogenic diet treatments in improving the age-related decline in brain function.

20 Jun 2024

Gprc5a identified as potential drug target for treating osteoporosis

Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage.

18 Jun 2024

How ketone bodies contribute to brain health and memory preservation

The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice.

17 Jun 2024

MEK inhibitor trametinib shows potential in pediatric JMML treatment

The MEK inhibitor trametinib (Mekinist) was an effective treatment for pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML) enrolled in a phase II clinical trial, with seven of 10 patients alive after a median of two years.

13 Jun 2024

Natural antioxidants could delay age-related decline in male testosterone production

Natural polyphenolic compounds to enhance testosterone production and prevent age-related hypogonadism in aging males.

12 Jun 2024

Microneedle patch holds promise for promoting hair regrowth caused by alopecia areata

Alopecia areata (AA) is an autoimmune disease characterized by hair loss, which occurs when T cells of the immune system mistakenly attack hair follicles.

8 Jun 2024

Innovative microneedle patch shows promise in treating alopecia areata

Alopecia areata (AA) is an autoimmune disease characterized by hair loss, which occurs when T cells of the immune system mistakenly attack hair follicles.

6 Jun 2024

Insomnia linked to higher ovarian cancer risk and mortality in new genetic study

Researchers found a significant genetic link between insomnia and increased risk and mortality in epithelial ovarian cancer (EOC).

4 Jun 2024

Elevated TMAO levels linked to higher diabetes risk, study finds

A recent Nutrients study links elevated trimethylamine N-oxide (TMAO) levels with an increased risk of type 2 diabetes, highlighting the role of diet in diabetes prevention.

4 Jun 2024

Blocking CDK7 protein could prevent heart damage associated with cancer treatment

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a study led by scientists at Washington State University.

4 Jun 2024

Research reveals new pathways for treating never-smoker lung cancer

The primary cause of lung cancer is smoking. However, the incidence of lung cancer among never-smokers has been steadily increasing, especially among women.

4 Jun 2024

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

The effects of statins via inhibition of interleukin 33 (IL-33).

3 Jun 2024

Targeting Ctdnep1: A potential therapeutic approach to combat bone loss

Osteoporosis, a condition characterized by porous and fragile bones, poses a significant threat to skeletal health.

30 May 2024

Statins may block an inflammation pathway involved in the development of cancer

A new study led by investigators from Mass General Cancer Center, a founding member of the Mass General Brigham healthcare system, reveals that statins-;commonly used cholesterol-lowering drugs-;may block a particular pathway involved in the development of cancer that results from chronic inflammation.

30 May 2024

Opioid receptors play unexpected role in gut nervous system development

Researchers at Rice University have revealed a previously unknown function of opioid receptors in the development of the enteric nervous system (ENS), often referred to as the "brain in the gut."

29 May 2024

Signaling Pathway News and Research

Researchers identify key players in abnormal bone differentiation

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

ALS: Newly discovered subtypes and sex differences create new approaches for drugs

New insights into signaling pathways and resistance mechanisms in colorectal cancer

Proteins in blood may help to predict Parkinson’s disease up to seven years before the onset of motor symptoms

Study reveals cognitive benefits of ketogenic diet in aged mice

Gprc5a identified as potential drug target for treating osteoporosis

How ketone bodies contribute to brain health and memory preservation

MEK inhibitor trametinib shows potential in pediatric JMML treatment

Natural antioxidants could delay age-related decline in male testosterone production

Microneedle patch holds promise for promoting hair regrowth caused by alopecia areata

Innovative microneedle patch shows promise in treating alopecia areata

Insomnia linked to higher ovarian cancer risk and mortality in new genetic study

Elevated TMAO levels linked to higher diabetes risk, study finds

Blocking CDK7 protein could prevent heart damage associated with cancer treatment

Research reveals new pathways for treating never-smoker lung cancer

Statins found to prevent chronic inflammation-related cancers by inhibiting interleukin-33

Targeting Ctdnep1: A potential therapeutic approach to combat bone loss

Statins may block an inflammation pathway involved in the development of cancer

Opioid receptors play unexpected role in gut nervous system development

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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