Sjogren's Syndrome News and Research

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Sjogren's syndrome is a chronic autoimmune syndrome characterized by lymphocyte infiltration of salivary glands, resulting in symptomatic eye and mouth dryness. Sjogren's syndrome can be associated with extraglandular presentations, such as musculoskeletal features including fatigue and fibromyalgia, in nearly 50% of patients, and fewer patients complain of arthralgias. According to the Sjogren's Syndrome Foundation, the condition affects approximately two million to four million Americans, mostly middle-age women.

X-chromosome inactivation and its role in autoimmune susceptibility in females

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

1 Feb 2024

Daily fetal heart rate monitoring recommended for pregnant women with high anti-SSA/Ro antibodies

Physicians who care for pregnant women have long sought to identify which of their patients would most likely benefit from monitoring of their fetus's heart rate to catch early signs of their unborn child developing heart problems tied to the mother's immune system.

7 Nov 2023

Study finds that patients with systemic autoimmune rheumatic diseases had a lower antibody response than healthy controls after Omicron infection

Study investigated if patients with systemic autoimmune rheumatic diseases (SARDs) have a reduced immunological response.

27 Jul 2023

Burden of autoimmune disease continues to increase over time, research suggests

EULAR – the European Alliance of Associations for Rheumatology – works on a broad spectrum of autoimmune and auto-inflammatory diseases.

31 May 2023

Study identifies a previously unknown role of 'natural killer' immune cells

Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of 'natural killer' (NK) immune cells.

10 Feb 2023

NYU Langone joins NIH-sponsored program as leading center to discover new targets for autoimmune, inflammatory diseases

NYU Langone Health is joining a new National Institutes of Health (NIH)-sponsored program called Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) as a leading center to discover new targets for therapy in these diseases.

30 Mar 2022

Scientists isolate individual cells that cause autoimmune disease

Researchers have homed in on the cells that cause an autoimmune disease to arise in the body. The study, published in the journal Cell in February 2020, as part of the far-seeing Hope Research project, reports on the discovery.

13 Feb 2020

Varied diets may be the cause for differences in human and non-human primate saliva

The study, published recently in Molecular Biology and Evolution, describes the discovery that human saliva is much more watery than the saliva of chimpanzees and gorillas.

31 Oct 2019

Early clinical trial of new treatment for severe dry eye disease shows promising results

Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology.

7 May 2019

The high cost of sex: Insurers often don’t pay for drugs to treat problems

For some older people, the joy of sex may be tempered by financial concerns: Can they afford the medications they need to improve their experience between the sheets?

19 Feb 2019

OU researcher and collaborators are developing new strategies for early intervention of Lupus

A University of Oklahoma researcher, Si Wu, and collaborators from the Oklahoma Medical Research Foundation and Indiana University, are developing new strategies leading to diagnosis and early intervention of Lupus, an autoimmune disease that may affect up to 1.5 million Americans.

1 Feb 2019

Gilead Sciences presents Phase 3 results of filgotinib in biologic-experienced rheumatoid arthritis at 2018 ACR/ARHP Annual Meeting

Gilead Sciences, Inc. and Galapagos NV today announced detailed results from the Phase 3 FINCH 2 clinical trial of filgotinib, an investigational, selective JAK1 inhibitor, in adults with moderately-to-severely active rheumatoid arthritis and prior inadequate response or intolerance to biologic agents.

22 Oct 2018

Scientists succeed in growing functional salivary gland

A research group led by scientists from Showa University and the RIKEN Center for Biosystems Dynamics Research in Japan have, for the first time, succeeded in growing three-dimensional salivary gland tissue that, when implanted into mice, produced saliva like normal glands.

11 Oct 2018

Silicone breast implants may increase risk of rare adverse outcomes in women

Women receiving silicone breast implants may be at increased risk of several rare adverse outcomes compared to the general population, reports a study in Annals of Surgery.

18 Sep 2018

Patients with rheumatologic disease can safely receive life-saving cancer immunotherapy

In the largest single-center study of patients with rheumatologic diseases who were prescribed modern cancer immunotherapy with what are called immune checkpoint inhibitors, only a minority of patients experienced a flare of their rheumatologic disease or immune-related side effects.

24 Jan 2018

TSRI researchers find potential way to treat aqueous deficiency dry eye

A new study in animal models, led by scientists at The Scripps Research Institute, suggests that the eye's lacrimal glands can be repaired by injecting a kind of regenerative "progenitor" cell.

18 Aug 2016

Two new studies find potential genetic cause and new treatment method for autoimmune diseases

The American Autoimmune Related Diseases Association, Inc. is spotlighting two new research studies originally reported in ScienceDaily.

13 Jul 2016

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Researchers at Hospital for Special Surgery have uncovered a potential genetic trigger of systemic autoimmune disease.

28 Jun 2016

Taking ipilimumab, nivolumab drugs may increase risk of developing rheumatologic diseases

Case reports on 13 cancer patients suggest that a small number of cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at some higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory arthritis, according to a preliminary study by Johns Hopkins Medicine researchers.

24 Jun 2016

New study links cathepsin S protein to tear secretion in Sjogren's syndrome patients

The autoimmune disorder Sjogren's syndrome is often overlooked or misdiagnosed because the symptoms are similar to other conditions. Its characteristic symptoms are dry eyes and dry mouth, and reduced tear production is used as part of the diagnosis.

4 May 2016