Small Molecules News and Research

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Overcoming adherence challenges: Innovative patch enables controlled drug delivery

A breakthrough in transdermal drug delivery.

17 Jan 2024

New molecule targets key protein in autoimmune diseases

Scientists from Scripps Research have developed a small molecule that blocks the activity of a protein linked to autoimmune diseases, including systemic lupus erythematosus (SLE) and Crohn's disease.

11 Jan 2024

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis.

8 Jan 2024

Scripps scientists develop powerful method to find drug targets in live cells

Identifying new ways to target proteins involved in human diseases is a priority for many researchers around the world.

2 Jan 2024

Understanding acylspermidines' secrets could lead to treatments for various diseases

In a significant advancement in the field of biochemistry, scientists at the Boyce Thompson Institute (BTI) and Cornell University have uncovered new insights into a family of metabolites, acylspermidines, that could change how we understand aging and fight diseases.

2 Jan 2024

Small molecule-switchable RNA platform enables control of therapeutic protein expression

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window.

2 Jan 2024

New method designs high-affinity, orally bioavailable peptides

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

28 Dec 2023

Researchers receive two grants to study tuberculosis drug development

Weill Cornell Medicine researchers and the TB Drug Accelerator have received two grants totaling $6.8 million from the Bill & Melinda Gates Foundation to study tuberculosis (TB) drug development.

26 Dec 2023

“Forever chemicals” could contribute to cancer metastasis in living organisms

In a new study by researchers at the Yale School of Public Health, two "forever chemicals" spurred cancer cells in the lab to migrate to new positions, an indication that the chemicals could contribute to cancer metastasis in living organisms.

18 Dec 2023

New study unpacks the hidden power of breastfeeding

Breastfeeding, even partially alongside formula feeding, changes the chemical makeup-;or metabolome-;of an infant's gut in ways that positively influence brain development and may boost test scores years later, suggests new CU Boulder research.

13 Dec 2023

$153,000 grant fuels research on new approaches to inhibit STAT3 and develop novel cancer treatments

With an estimated 1.9 million new cases and more than 600,000 deaths each year, cancer remains the second most common cause of death in the U.S., trailing only heart disease. And while there are more than 200 types of cancer, the abnormal synthesis of a protein known as STAT3 is unique to the majority of tumors.

13 Dec 2023

Small molecules could help stroke patients recover lost function

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

30 Nov 2023

Macrocyclic compounds: A promising class of drugs for cancer treatment

This review was designed by Professor Xiaoling Song and Professor Biao Jiang and written by Pr. Xiaoling Song and a Ph.D. student, Yifan Wu (Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University) to summarize the application of macrocyclic molecules in cancer treatment.

29 Nov 2023

Insilico Medicine hosts three webinars to unveil latest technology breakthroughs

Insilico Medicine ("Insilico"), an artificial intelligence (AI)-driven, clinical stage biotechnology company and leader in AI drug discovery platform technology, is hosting three webinars unveiling its latest technology breakthroughs Nov. 28-30, 2023.

29 Nov 2023

Non-invasive monitoring of glucose and adenosine monophosphate biomarkers in saliva

Blood tests are a common, yet often painful, step in health care. But what if we could skip the needles altogether? Saliva and blood contain many of the same biomarkers, and collecting spit is as simple as drooling into a container.

29 Nov 2023

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

Discovery of a novel cardiac-specific myosin modulator.

28 Nov 2023

Machine learning uncovers potent immunomodulators for vaccines and immunotherapy

Small molecules called immunomodulators can help create more effective vaccines and stronger immunotherapies to treat cancer.

17 Nov 2023

Bacteria fight phages with RNA-based immune defense

There's no organism on earth that lives free of threat-;including bacteria. Predatory viruses known as phages are among their most dire foes, infiltrating their cells to replicate and take over.

15 Nov 2023

Scientists discover kidney-friendly antifungal that evades resistance

In this investigation, researchers produced powerful antifungals of the polyene class without nephrotoxicity.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Small Molecules News and Research

Overcoming adherence challenges: Innovative patch enables controlled drug delivery

New molecule targets key protein in autoimmune diseases

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

Scripps scientists develop powerful method to find drug targets in live cells

Understanding acylspermidines' secrets could lead to treatments for various diseases

Small molecule-switchable RNA platform enables control of therapeutic protein expression

New method designs high-affinity, orally bioavailable peptides

Researchers receive two grants to study tuberculosis drug development

“Forever chemicals” could contribute to cancer metastasis in living organisms

New study unpacks the hidden power of breastfeeding

$153,000 grant fuels research on new approaches to inhibit STAT3 and develop novel cancer treatments

Small molecules could help stroke patients recover lost function

Macrocyclic compounds: A promising class of drugs for cancer treatment

Insilico Medicine hosts three webinars to unveil latest technology breakthroughs

Non-invasive monitoring of glucose and adenosine monophosphate biomarkers in saliva

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

Machine learning uncovers potent immunomodulators for vaccines and immunotherapy

Bacteria fight phages with RNA-based immune defense

Scientists discover kidney-friendly antifungal that evades resistance

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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