Smallpox News and Research

RSS

Smallpox is a highly contagious disease caused by the variola virus, a member of the Orthopox virus family. It is one of the most devastating diseases known to humanity, with a mortality rate as high as 30%. In 1967, the World Health Organization embarked upon an intensified vaccination campaign to eliminate smallpox, which culminated in the successful eradication of the disease globally by 1980.

By the mid-1980s, there were only two known repositories of variola virus: the Institute of Virus Preparations in Russia, and the US CDC. The events in the US in September and October 2001 highlighted the risk that the variola virus might be used as an agent of bioterrorism. Governments around the world are taking precautionary measures to be ready to deal with a potential smallpox outbreak.

FDA committee votes in favor of Acambis' smallpox vaccine

Acambis plc announced that the Vaccines and Related Biological Products Advisory Committee of the US Food and Drug Administration (FDA) voted unanimously that Acambis' smallpox vaccine, ACAM2000, is both safe and efficacious.

18 May 2007

Herpes infection may be symbiotic

Mice with chronic herpes virus infections can better resist the bacterium that causes plague and a bacterium that causes one kind of food poisoning, researchers report in Nature.

17 May 2007

Protecting Americans against a smallpox outbreak

In the event of a smallpox outbreak in the United States, how long would it take for a vaccine to start protecting Americans by stimulating an immune response? A new national study led by Saint Louis University School of Medicine will attempt to answer this question.

1 May 2007

Should stocks of smallpox virus be destroyed?

Smallpox was eradicated in 1980, but the virus still exists in WHO controlled depositories. In this week's BMJ , two experts go head to head over whether these stocks should be destroyed.

15 Apr 2007

BioForce Nanosciences pursues support for ViriChip platform

BioForce Nanosciences continues their effort to fund development of the ViriChip platform, a patented system designed to rapidly and nondestructively detect and identify whole viruses.

12 Apr 2007

Canada plans to acquire MVA-based smallpox vaccine

The Department of National Defence (DND) in Canada has issued a request for proposal for the acquisition of MVA based smallpox vaccines for the protection of 10,000 people and an option for protecting another 10,000 people.

11 Apr 2007

World moves closer to eradicating ancient worm disease

A neglected tropical disease that has afflicted people since ancient times has moved a step closer towards eradication. In early March, twelve more countries were declared Guinea Worm Free by the International Commission for the Certification of Dracunculiasis (Guinea Worm Disease) Eradication.

27 Mar 2007

Global resurgence in zoonotic viral diseases

Doctors and veterinarians need to work together to tackle the increasing global threat of zoonotic viral diseases spread by non-human vertebrate hosts - including dogs, cattle, chickens and mosquitoes - according to a review in the November issue of Journal of Internal Medicine.

8 Nov 2006

Bavarian Nordic's modified Vaccinia Ankara patents infringed

The Administrative Law Judge at the U.S. International Trade Commission (ITC) issued his Initial Determination concluding that Acambis plc's smallpox vaccine product (MVA3000) infringes two of Bavarian Nordic's patents on Modified Vaccinia Ankara (MVA) and furthermore that Bavarian Nordic's patents are enforceable.

11 Sep 2006

Turning the immune system against cancer

Medicine can now prevent a host of diseases with a mere shot of vaccine. Polio and smallpox are almost non-existent, and mumps and chicken pox are rarely seen nowadays.

4 Aug 2006

Researchers determine structure of an important smallpox virus enzyme and how it binds to DNA

Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA.

4 Aug 2006

Simple policies could control a smallpox epidemic

A series of simple public health policies would be able to effectively contain the spread of smallpox if it were released into a population, according to research published in PNAS.

27 Jul 2006

Bioinformatics used to advance human disease research

The use of computers to advance human disease research - known as bioinformatics -- has received a major boost from researchers at the La Jolla Institute for Allergy & Immunology (LIAI).

18 Jun 2006

WHO suffers tragic loss of a visionary leader

The Director-General of the World Health Organisation, Dr. Lee Jong-wook of South Korea, has died suddenly following surgery for a blood clot on the brain.

22 May 2006

Novel virus entry mechanism could lead to new drugs against poxviruses

Scientists working with Vaccinia virus, the smallpox vaccine, have discovered a novel mechanism that allows poxviruses to enter cells and cause infection.

13 Apr 2006

Clear evidence that elephantiasis can be eliminated

Clear evidence that Lymphatic Filariasis (LF, commonly known as elephantiasis) can be eliminated is reported in The Lancet. LF is one of the world's most disfiguring and disabling parasitic diseases, and the target of one of the largest global public health programs using mass drug administration (MDA).

28 Mar 2006

Immune system protein LL-37 critical in controlling replication of vaccinia virus

Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have identified a defect in the immune response of people with the skin condition atopic dermatitis that puts them at risk of developing serious complications following smallpox vaccination.

23 Mar 2006