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Study highlights immune escape mutations in viral N-terminal domain supersite of SARS-CoV-2 spike variants

Researchers characterized SARS-CoV-2 spike (S) isolates extracted from the samples of two individuals infected with the virus in Peru (ΔN25) and Brazil (ΔN135) in January 2021.

6 Apr 2022

Gut bacterium may be an important factor in resistance to antihypertensive medications

Almost half of the U.S. adult population has high blood pressure - or hypertension - and about 20% of these patients have treatment-resistant hypertension.

5 Apr 2022

Researchers use breast milk to identify new set of protein biomarkers for cancer

A simple blood test for women of all ages and risk levels could one day be possible thanks to a new set of protein biomarkers that researchers identified using breast milk.

4 Apr 2022

A summary of SARS-CoV-2 RNA-protein interactome studies

A new study summarized the importance of SARS-CoV-2 ribonucleic acid protein interactomes in the study of RNA viruses.

30 Mar 2022

IgG Fc glycosylation: A marker for severe COVID-19

Researchers suggest that low anti-spike IgG1 glycosylation, sialyation, and high bisection are markers of severe COVID-19.

24 Mar 2022

New approach could lead to quicker generation of effective, personalized cancer vaccines

Scientists have created a pipeline for identifying, prioritizing and evaluating potential tumor antigens for the fast generation of cancer vaccines, according to a report published today in eLife.

22 Mar 2022

Influence of vitamin D and age on first SARS-CoV-2 vaccine dose efficacy

Researchers illustrated that vitamin D status and age influence antibody response following the initial dose of coronavirus disease 2019 vaccination.

21 Mar 2022

Antimicrobial resistance in COVID-19

Researchers discuss the impact of this extensive use of antibiotics on the rise of antimicrobial resistance.

16 Mar 2022

Acacetin shows potency against SARS-CoV-2 spike protein

Researchers use molecular docking to screen phytocompounds and evaluate their binding affinity with SARS-CoV-2.

15 Mar 2022

Detailed molecular map of stratum corneum can help develop new skin treatments

Scientists have accurately analyzed the tough barrier layer of the skin giving the most detailed molecular map of its structure that will help in the development of new skin products and treatments.

14 Mar 2022

UNC researchers offer solution to detect, issue warnings about tainted street drugs

With new grant funding, Nabarun Dasgupta '13 (Ph.D.), Gillings Innovation Fellow at the UNC-Chapel Hill Gillings School of Global Public Health and senior scientist at the UNC Injury Prevention Research Center, will work with colleagues across Carolina to develop systems to detect and issue public warnings about dangerous adulterants in street drugs.

14 Mar 2022

Researchers find unusual way of stabilizing cancer-suppressing protein

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent.

14 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that the lower expression of EXOSC2 human protein safeguards from clinical coronavirus disease 2019 (COVID-19). This protective effect was via the reduced EXOSC2 expression-associated suppression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.

9 Mar 2022

New analysis method to identify interacting proteins in a protein degrader-dependent manner

Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells.

8 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Spectrometry News and Research

Study highlights immune escape mutations in viral N-terminal domain supersite of SARS-CoV-2 spike variants

Gut bacterium may be an important factor in resistance to antihypertensive medications

Researchers use breast milk to identify new set of protein biomarkers for cancer

A summary of SARS-CoV-2 RNA-protein interactome studies

IgG Fc glycosylation: A marker for severe COVID-19

New approach could lead to quicker generation of effective, personalized cancer vaccines

Influence of vitamin D and age on first SARS-CoV-2 vaccine dose efficacy

Antimicrobial resistance in COVID-19

Acacetin shows potency against SARS-CoV-2 spike protein

Detailed molecular map of stratum corneum can help develop new skin treatments

UNC researchers offer solution to detect, issue warnings about tainted street drugs

Researchers find unusual way of stabilizing cancer-suppressing protein

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

New analysis method to identify interacting proteins in a protein degrader-dependent manner

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Manipulating carotenoids can improve plant growth, stress tolerance and increase yield

Aldosterone levels undetectably low in hospitalized COVID-19 patients

Gas chromatography-ion mobility spectrometry helps diagnose COVID-19 and predict disease severity

Realizing the Importance of Medical Electronic Devices

Everything about SpatialOMx

How the science of happiness is helping student mental health

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