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Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

22 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Unlocking gut health: How indoor environment impacts the microbiota balance

Research paper highlights the importance of a diverse and balanced gut microbiota for human health, while emphasizing the need for further understanding of the impact of indoor microbiome and metabolites on gut microbiota.

21 May 2023

Food preservative nisin: A gut game changer that safely alters microbiome composition

Nisin, a powerful bacteriocin, influences the gut microbiota and its functionality by modulating the abundance of specific bacterial groups and altering short-chain fatty acid synthesis.

18 May 2023

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action.

18 May 2023

Novel computational platform can expand the pool of cancer immunotherapy targets

Researchers at Children's Hospital of Philadelphia (CHOP) and the University of California, Los Angeles (UCLA) have developed a computational platform capable of discovering tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.

17 May 2023

Molecular mechanism behind a DNA repair pathway revealed

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

16 May 2023

H.E.L Group makes senior appointments as it continues to scale globally

Hasan Hallaq, PhD appointed as European Sales Director, Victoria Ordsmith joins as Director of Marketing and Sarennah Longworth-Cook promoted Director of People.

From H.E.L Group 16 May 2023

Integrated proteomics approach identifies the contents of p62 bodies in detail

Our body functioning is delicately balanced between the synthesis and breakdown of various cellular components.

15 May 2023

SARS-CoV-2 variants show altered glycan processing

Researchers examine spike-protein trimers from SARS-CoV-2 variants to compare the N (asparagine)-glycan landscape.

15 May 2023

Novel ingestible device enables non-invasive profiling of the gut microbiome, proteome, and metabolome

Researchers developed an ingestible device to collect samples from the human intestine.

12 May 2023

A machine-learning approach for the early diagnosis of Parkinson's disease

Scientists discuss a machine learning-based tool that can detect Parkinson's disease years before the first onset of symptoms.

11 May 2023

New antimicrobial coating material effectively kills bacteria and viruses

Researchers have used a common disinfectant and antiseptic to create a new antimicrobial coating material that effectively kills bacteria and viruses, including MRSA and Covid-19.

11 May 2023

Leaves of the Labrador tea plant contain an essential oil that could help combat malaria

Much of what is now considered modern medicine originated as folk remedies or traditional, Indigenous practices. These customs are still alive today, and they could help address a variety of conditions.

11 May 2023

Leveraging proteomics datasets to discover potential therapeutic targets for cancer patients

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

10 May 2023

New AI tool shows early promise in detecting Parkinson's disease years before symptom onset

Scientists from UNSW Sydney with collaborators at Boston University have developed a tool that shows early promise in detecting Parkinson's disease years before the first symptoms start appearing.

9 May 2023

New toolkit enables in-vivo cross-linking of protein complexes in live cells

As the executor of life activities, proteins exert their specific biological functions through interactions such as forming protein complexes.

9 May 2023

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

Researchers evaluated metabolic profile changes of the skin in relation to microbiota and UV exposure.

5 May 2023

The African Personalized Medicine Agenda

In this interview, Rizwana Mia, the Senior Program Manager at South African Medical Research Council, talks to News Medical about the African personalized medicine agenda.

From MGI 4 May 2023

Spectrometry News and Research

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Surviving without glucose: uridine-derived ribose as an alternative energy source

Unlocking gut health: How indoor environment impacts the microbiota balance

Food preservative nisin: A gut game changer that safely alters microbiome composition

Researchers discover how corticosteroids influence inflammatory response during COVID-19 infection

Novel computational platform can expand the pool of cancer immunotherapy targets

Molecular mechanism behind a DNA repair pathway revealed

H.E.L Group makes senior appointments as it continues to scale globally

Integrated proteomics approach identifies the contents of p62 bodies in detail

SARS-CoV-2 variants show altered glycan processing

Novel ingestible device enables non-invasive profiling of the gut microbiome, proteome, and metabolome

A machine-learning approach for the early diagnosis of Parkinson's disease

New antimicrobial coating material effectively kills bacteria and viruses

Leaves of the Labrador tea plant contain an essential oil that could help combat malaria

Leveraging proteomics datasets to discover potential therapeutic targets for cancer patients

New AI tool shows early promise in detecting Parkinson's disease years before symptom onset

New toolkit enables in-vivo cross-linking of protein complexes in live cells

The dynamics and interactions between the skin metabolome, microbiome, and UV exposure

The African Personalized Medicine Agenda

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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