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New study links hepatic inflammation to western diet

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males. Moreover, liver inflammation was most pronounced in Western diet-fed male mice that also lacked farnesoid x receptor (FXR), a bile acid receptor.

12 Jul 2017

Monounsaturated fats promote fatty liver disease, study finds

As the obesity epidemic continues, new data shed light on which nutrients and what quantity of those nutrients promote health or disease.

14 Jun 2017

Can liver damage caused by a low protein diet be repaired?

Proteins are an important component of our diet and help to build muscles; they take part in the structure of hormones and they are vital to the whole body’s metabolism. The most important consequence is that the liver loses its capacity to produce proteins (such as albumin) and to metabolise (inactivate or activate in some cases) medicaments for instance.

8 Jun 2017

Endoplasmic reticulum stress in the brain may cause non-alcoholic fatty liver disease

Disruptions in a protein folding process occurring in the brain, known as endoplasmic reticulum (ER) stress, may cause non-alcoholic fatty liver disease, independent of other factors. A research team at the George Washington University published their results in the Journal of Clinical Investigation Insight.

25 May 2017

Breast cancer drug offers protection against obesity-related metabolic disorders

Tamoxifen, a selective estrogen receptor modulator, is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer.

11 May 2017

Brown fat in humans: more than previously thought

Brown fat is a tissue well studied in small mammals, where it acts as a heat-producing organ to stay warm in a cold environment. Its unequivocal identification in adult, healthy humans about a decade ago is of major importance due to its immense capacity to convert chemical energy into heat

20 Apr 2017

Dietary fructose consumption may increase risk for NASH in children and adolescents

Recent research suggests that dietary fructose intake may increase serum uric acid concentrations and that both uric acid concentration and fructose consumption may be increased in individuals with non-alcoholic fatty liver disease.

14 Feb 2017

Study provides insights into CPEB4 gene and fatty liver disease

This condition generally leads to chronic inflammation (non-alcoholic steatohepatitis), which can trigger fibrosis, cirrhosis and ultimately liver cancer. This study on the basic biology of the liver paves the way to examine therapeutic strategies to fight and prevent fatty liver disease.

18 Jan 2017

Vitamin D supplementation improves metabolic syndrome in mice

It is well known that a diet high in fat can trigger a metabolic syndrome, a group of symptoms that pose as risk factors for diabetes and heart disease.

22 Dec 2016

NASPGHAN clinical practice guidelines recommend screening test for NAFLD in obese children

A screening test for non-alcoholic fatty liver disease (NAFLD)--a serious condition that may have lifelong health consequences--is recommended for all obese children aged nine to eleven years, according to clinical practice guidelines developed by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and published in the Journal of Pediatric Gastroenterology and Nutrition.

1 Dec 2016

Researchers forecast obesity-related conditions to rise among children

Researchers' global estimates indicate that by 2025, some 268 million children aged 5 to 17 years may be overweight, including 91 million obese, assuming no policy interventions have proven effective at changing current trends.

8 Oct 2016

Researcher receives grant to study how changes in gut bacteria could lead to obesity-related disorders

Andrew Gewirtz, a professor in the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.8-million federal grant to study how changes in intestinal bacteria could lead to obesity and metabolic syndrome.

9 Aug 2016

Sleep-disordered breathing promotes progression of pediatric NAFLD to NASH

Studies have shown that obstructive sleep apnea and low nighttime oxygen, which result in oxidative stress, are associated with the progression of non-alcoholic fatty liver disease (NAFLD) in adults.

5 Aug 2016

New diagnostic model may become cheaper and easier alternative to screen for NAFLD

Researchers have developed a diagnostic model that is highly predictive of nonalcoholic fatty liver disease (NAFLD).

13 Jul 2016

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable.

12 Jul 2016

Targeted molecular therapy reduces initial development of NAFLD in mice

Researchers report in the journal Cell Reports a targeted molecular therapy that dramatically reduces the initial development of Non Alcoholic Fatty Liver Disease (NAFLD) in laboratory mouse models of the disease.

1 Jul 2016

Researchers develop in vitro model system for investigating etiology of NAFLD

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD).

30 Jun 2016

Pioglitazone effective in diabetes patients with NASH

Pioglitazone may halt the progression of nonalcoholic steatohepatitis in patients with prediabetes or Type 2 diabetes, a randomised trial shows.

28 Jun 2016

NR supplements can reduce diabetes-related complications in mice

A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System.

27 May 2016

Daily dose of coffee could help reverse non-alcoholic fatty liver disease

Adding coffee to the diet of people with non-alcoholic fatty liver disease (NAFLD) could help reverse the condition, according to a new study conducted in mice presented at The International Liver Congress 2016 in Barcelona, Spain.

13 Apr 2016