Stereocilia News and Research

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Stereocilia are apical modifications of the cell, which are distinct from microvilli and cilia.

SMPX gene mutation causes hereditary hearing impairment

Excessive noise is not the only thing that causes damage to hearing. In many cases, genetic factors are responsible for the loss of hearing at a young age. Researchers at the Max Planck Institute for Molecular Genetics in Berlin together with colleagues from Nijmegen have discovered a previously unknown genetic cause of progressive hearing impairment: the disease is caused by mutations of the SMPX gene, which is located on the X chromosome.

1 Jun 2011

New way to coax embryonic stem cells and reprogrammed adult cells to develop sensory cells

After ten years of effort, researchers reporting in the May 14th issue of the journal Cell, a Cell Press publication, say they have found a way to coax embryonic stem cells as well as reprogrammed adult cells to develop into sensory cells that normally reside in the mammalian inner ear. Those mechanosensitive sensory hair cells are the linchpin of hearing and balance.

14 May 2010

Stanford researchers make hair-cell-like cells in a petri dish

Deep inside the ear, specialized cells called hair cells detect vibrations in the air and translate them into sound. Ten years ago, Stefan Heller, PhD, professor of otolaryngology at the Stanford University School of Medicine, came up with the idea that if you could create these cells in the laboratory from stem cells, it would go a long way toward helping scientists understand the molecular basis of hearing in order to develop better treatments for deafness.

14 May 2010

Genetic cause of progressive hearing loss discovered

A team led by scientists from The Scripps Research Institute has discovered a genetic cause of progressive hearing loss. The findings will help scientists better understand the nature of age-related decline in hearing and may lead to new therapies to prevent or treat the condition.

4 Sep 2009

Discovery of molecular defect involved in hearing loss

Scientists from The Scripps Research Institute have elucidated the action of a protein, harmonin, which is involved in the mechanics of hearing.

13 May 2009

Discovery of ion channel turns ear on its head

Scientists thought they had a good model to explain how the inner ear translates vibrations in the air into sounds heard by the brain.

23 Apr 2009

A nanoscale motor in the ear

Utah and Texas researchers have learned how quiet sounds are magnified by bundles of tiny, hair-like tubes atop "hair cells" in the ear: when the tubes dance back and forth, they act as "flexoelectric motors" that amplify sound mechanically.

22 Apr 2009

Research links low-frequency hearing to shape of the cochlea

Shape matters, even in hearing. Specifically, it is the shape of the cochlea - the snail-shell-shaped organ in the inner ear that converts sound waves into nerve impulses that the brain deciphers - which proves to be surprisingly important.

27 Apr 2008

Zebrafish help understand hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, it's not the fish's ears that are of interest.

1 Mar 2008

Hearing protein TRPA1 also involved with pain perception

The same protein that “translates” sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found.

21 Jul 2005

Protein TRPA1 essential for hearing also vital for pain perception

The same protein that "translates" sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found.

25 May 2005

Discovery of molecule that is part of the machinery that mediates the sense of hearing

A group of scientists at The Scripps Research Institute, at the University of California in San Diego, and at the Oregon Hearing Research Center and Vollum Institute at Oregon Health & Science University have discovered a key molecule that is part of the machinery that mediates the sense of hearing.

28 Mar 2004