Structural Biology News and Research

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Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

New Pyk2-derived peptide inhibits breast cancer metastasis

An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory system, and form new, metastatic tumors in other parts of the body.

17 Jan 2023

Newly discovered CRISPR immune system shuts down infected cells to thwart infection

In this interview, News Medical speaks to Assitant Professor Ryan Jackson about his latest work, published in tandem Nature papers, detailing the discovery of a new CRISPR immune system.

11 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023

Understanding the molecular basis of how THC cannabinoid inhibits an important human enzyme

In various European countries and North America, medical cannabis or medicines based on cannabinoids are authorized for therapeutic purposes.

9 Jan 2023

New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

Recently discovered protein holds potential for the development of new tests for infectious diseases

In a first for the genetic toolset known as CRISPR, a recently discovered protein has been found to act as a kind of multipurpose self-destruct system for bacteria, capable of degrading single-stranded RNA, single-stranded DNA and double-stranded DNA.

4 Jan 2023

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Researchers from Paul Scherrer Institute PSI and ETH Zurich have discovered how proteins in the cell can form tiny liquid droplets that act as a smart molecular glue.

19 Dec 2022

Decoding nucleic acid-based drugs and vaccines through SEC-SLS analysis

In this interview, Malvern Panalytical’s Product Technical Specialist, Stefan Cairns, discusses how SEC-SLS can be used to understand MRNA vector composition by referencing his latest publication.

From Malvern Panalytical 19 Dec 2022

Researchers discover a new function of CRISPR/Cas9 gene scissors

For several years now, the CRISPR/Cas9 gene scissors have been causing a sensation in science and medicine.

25 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Creating New Targeted Antibacterial Products to Help Tackle Antimicrobial Resistance

We speak to Matthew Dunne, Director for Drug Discovery at Micreos Pharmaceuticals, about the importance of creating new targeted antibacterial products.

22 Nov 2022

Collaboration aims to develop new medicines for neurodegenerative diseases

The ALBORADA Drug Discovery Institute (ADDI) today (Tuesday 8 November) announced that it will collaborate with pharmaceutical company YD Global Life Science (YDGLS) to develop inhibitors of the unfolded protein response for the treatment of the diseases that cause dementia.

9 Nov 2022

Mouse model reveals how RNA splicing defects contribute to neurodegeneration in Alzheimer's disease

Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive.

13 Oct 2022

New cell-free protein crystallization method: A major headway in the field of structural biology

The new cell-free protein crystallization (CFPC) method developed by Tokyo Tech includes direct protein crystallization and is a major headway in the field of structural biology.

3 Oct 2022

Research reveals how carp virus uses a protein domain to inhibit host cell’s defense mechanisms

The team of Prof. Alain Vanderplasschen, virologist and immunologist at the University of Liège, has published an article in the journal Nucleic Acids Research, reporting ten years of research on how a carp virus has been using a protein domain called Zalpha (Zα) to inhibit the defense mechanisms of the host cell.

23 Sep 2022

Researchers identify universal features shaping organelle gene retention

Mitochondria are compartments – so-called "organelles" -- in our cells that provide the chemical energy supply we need to move, think, and live.

16 Sep 2022

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19's viral pathogenesis -; a theory that was posited two years ago by a team of researchers at the Department of Energy's Oak Ridge National Laboratory.